ID A2AEX0_MOUSE Unreviewed; 651 AA. AC A2AEX0; DT 20-FEB-2007, integrated into UniProtKB/TrEMBL. DT 20-FEB-2007, sequence version 1. DT 30-NOV-2016, entry version 88. DE SubName: Full=Potassium voltage-gated channel, Shal-related family, member 1 {ECO:0000313|EMBL:AAI39326.1}; GN Name=Kcnd1 {ECO:0000313|EMBL:AAI39326.1, ECO:0000313|MGI:MGI:96671}; GN ORFNames=mCG_3943 {ECO:0000313|EMBL:EDL33924.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI39326.1}; RN [1] {ECO:0000313|EMBL:EDL33924.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL33924.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [2] {ECO:0000313|EMBL:AAI39326.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAI39326.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] {ECO:0000313|EMBL:EDL33924.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL33924.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- SIMILARITY: Belongs to the potassium channel family. CC {ECO:0000256|SAAS:SAAS00537498}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC139325; AAI39326.1; -; mRNA. DR EMBL; BC139327; AAI39328.1; -; mRNA. DR EMBL; CH466638; EDL33924.1; -; Genomic_DNA. DR RefSeq; NP_032449.1; NM_008423.2. DR UniGene; Mm.335968; -. DR STRING; 10090.ENSMUSP00000009875; -. DR GeneID; 16506; -. DR KEGG; mmu:16506; -. DR CTD; 3750; -. DR MGI; MGI:96671; Kcnd1. DR eggNOG; KOG4390; Eukaryota. DR eggNOG; COG1226; LUCA. DR HOVERGEN; HBG106687; -. DR KO; K04891; -. DR OMA; PREQPCG; -. DR OrthoDB; EOG091G18X0; -. DR Bgee; ENSMUSG00000009731; -. DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl. DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro. DR Gene3D; 1.20.120.350; -; 1. DR InterPro; IPR000210; BTB/POZ_dom. DR InterPro; IPR027359; Channel_four-helix_dom. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR003968; K_chnl_volt-dep_Kv. DR InterPro; IPR003975; K_chnl_volt-dep_Kv4. DR InterPro; IPR004054; K_chnl_volt-dep_Kv4.1. DR InterPro; IPR024587; K_chnl_volt-dep_Kv4_C. DR InterPro; IPR021645; Shal-type_N. DR InterPro; IPR011333; SKP1/BTB/POZ. DR InterPro; IPR003131; T1-type_BTB. DR InterPro; IPR028325; VG_K_chnl. DR PANTHER; PTHR11537; PTHR11537; 1. DR Pfam; PF02214; BTB_2; 1. DR Pfam; PF11879; DUF3399; 1. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF11601; Shal-type; 1. DR PRINTS; PR00169; KCHANNEL. DR PRINTS; PR01516; KV41CHANNEL. DR PRINTS; PR01491; KVCHANNEL. DR PRINTS; PR01497; SHALCHANNEL. DR SMART; SM00225; BTB; 1. DR SUPFAM; SSF54695; SSF54695; 1. PE 1: Evidence at protein level; KW Ion channel {ECO:0000256|SAAS:SAAS00417203}; KW Ion transport {ECO:0000256|SAAS:SAAS00417186}; KW Membrane {ECO:0000256|SAAS:SAAS00460873, ECO:0000256|SAM:Phobius}; KW Potassium {ECO:0000256|SAAS:SAAS00417282}; KW Potassium channel {ECO:0000256|SAAS:SAAS00417246}; KW Potassium transport {ECO:0000256|SAAS:SAAS00417240}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00460807, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00461080, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}; KW Voltage-gated channel {ECO:0000256|SAAS:SAAS00417262}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 651 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008754152. FT TRANSMEM 187 205 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 259 281 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 326 347 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 359 375 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 387 408 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 40 139 BTB (POZ). {ECO:0000259|SMART:SM00225}. SQ SEQUENCE 651 AA; 71698 MW; 801DECC3C56C721F CRC64; MAAGVATWLP FARAAAVGWL PLAQQPLPPA PEVKASRGDE VLVVNVSGRR FETWKNTLDR YPDTLLGSSE KEFFYDAESG EYFFDRDPDM FRHVLNFYRT GRLHCPRQEC IQAFDEELAF YGLVPELVGD CCLEEYRDRK KENAERLAED EEAEQAGEGP ALPAGSSLRQ RLWRAFENPH TSTAALVFYY VTGFFIAVSV IANVVETIPC RGTPRWPSKE QSCGDRFPTA FFCMDTACVL IFTGEYLLRL FAAPSRCRFL RSVMSLIDVV AILPYYIGLF VPKNDDVSGA FVTLRVFRVF RIFKFSRHSQ GLRILGYTLK SCASELGFLL FSLTMAIIIF ATVMFYAEKG TSKTNFTSIP AAFWYTIVTM TTLGYGDMVP STIAGKIFGS ICSLSGVLVI ALPVPVIVSN FSRIYHQNQR ADKRRAQQKV RLARIRLAKS GTTNAFLQYK QNGGLEDSGS GDGQMLCVRS RSAFEQQHHH LLHCLEKTTC HEFTDELTFS EALGAVSLGG RTSRSTSVSS QPMGPGSLFS SCCSRRVNRR AIRLANSTAS VSRGSMQELD TLAGLRRSPA PQTRSSLNAK PHDSLDLNCD SRDFVAAIIS IPTPPANTPD ESQPSSPSGG GGSGGTPNTT LRNSSLGTPC LLPETVKISS L //