ID A2AEX0_MOUSE Unreviewed; 651 AA. AC A2AEX0; DT 20-FEB-2007, integrated into UniProtKB/TrEMBL. DT 20-FEB-2007, sequence version 1. DT 29-MAY-2024, entry version 138. DE SubName: Full=Potassium voltage-gated channel, Shal-related family, member 1 {ECO:0000313|EMBL:AAI39326.1}; GN Name=Kcnd1 {ECO:0000313|EMBL:AAI39326.1, ECO:0000313|MGI:MGI:96671}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI39326.1}; RN [1] {ECO:0000313|EMBL:AAI39326.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAI39326.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite CC {ECO:0000256|ARBA:ARBA00004279}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC139325; AAI39326.1; -; mRNA. DR EMBL; BC139327; AAI39328.1; -; mRNA. DR RefSeq; NP_032449.1; NM_008423.2. DR AlphaFoldDB; A2AEX0; -. DR SMR; A2AEX0; -. DR PeptideAtlas; A2AEX0; -. DR Antibodypedia; 370; 301 antibodies from 31 providers. DR DNASU; 16506; -. DR GeneID; 16506; -. DR KEGG; mmu:16506; -. DR AGR; MGI:96671; -. DR CTD; 3750; -. DR MGI; MGI:96671; Kcnd1. DR VEuPathDB; HostDB:ENSMUSG00000009731; -. DR HOGENOM; CLU_011722_9_1_1; -. DR OMA; RFPMAFF; -. DR OrthoDB; 1478695at2759; -. DR BioGRID-ORCS; 16506; 6 hits in 79 CRISPR screens. DR ChiTaRS; Kcnd1; mouse. DR ExpressionAtlas; A2AEX0; baseline and differential. DR GO; GO:0043197; C:dendritic spine; IEA:TreeGrafter. DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl. DR GO; GO:0045211; C:postsynaptic membrane; IEA:TreeGrafter. DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. DR GO; GO:0005250; F:A-type (transient outward) potassium channel activity; IEA:TreeGrafter. DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro. DR Gene3D; 1.10.287.70; -; 1. DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1. DR InterPro; IPR000210; BTB/POZ_dom. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR003968; K_chnl_volt-dep_Kv. DR InterPro; IPR003975; K_chnl_volt-dep_Kv4. DR InterPro; IPR004054; K_chnl_volt-dep_Kv4.1. DR InterPro; IPR024587; K_chnl_volt-dep_Kv4_C. DR InterPro; IPR021645; Shal-type_N. DR InterPro; IPR011333; SKP1/BTB/POZ_sf. DR InterPro; IPR003131; T1-type_BTB. DR InterPro; IPR027359; Volt_channel_dom_sf. DR PANTHER; PTHR11537:SF174; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 1; 1. DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1. DR Pfam; PF02214; BTB_2; 1. DR Pfam; PF11879; DUF3399; 1. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF11601; Shal-type; 1. DR PRINTS; PR00169; KCHANNEL. DR PRINTS; PR01516; KV41CHANNEL. DR PRINTS; PR01491; KVCHANNEL. DR PRINTS; PR01497; SHALCHANNEL. DR SMART; SM00225; BTB; 1. DR SUPFAM; SSF54695; POZ domain; 1. DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1. PE 1: Evidence at protein level; KW Cell projection {ECO:0000256|ARBA:ARBA00023273}; KW Ion channel {ECO:0000256|ARBA:ARBA00023303}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Potassium {ECO:0000256|ARBA:ARBA00022958}; KW Potassium channel {ECO:0000256|ARBA:ARBA00022826}; KW Potassium transport {ECO:0000256|ARBA:ARBA00022538}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}; KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}. FT SIGNAL 1..16 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 17..651 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5014296787" FT TRANSMEM 187..205 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 259..281 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 326..347 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 359..375 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 387..408 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 40..139 FT /note="BTB" FT /evidence="ECO:0000259|SMART:SM00225" FT REGION 144..164 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 566..585 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 601..651 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 568..582 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 612..651 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 651 AA; 71698 MW; 801DECC3C56C721F CRC64; MAAGVATWLP FARAAAVGWL PLAQQPLPPA PEVKASRGDE VLVVNVSGRR FETWKNTLDR YPDTLLGSSE KEFFYDAESG EYFFDRDPDM FRHVLNFYRT GRLHCPRQEC IQAFDEELAF YGLVPELVGD CCLEEYRDRK KENAERLAED EEAEQAGEGP ALPAGSSLRQ RLWRAFENPH TSTAALVFYY VTGFFIAVSV IANVVETIPC RGTPRWPSKE QSCGDRFPTA FFCMDTACVL IFTGEYLLRL FAAPSRCRFL RSVMSLIDVV AILPYYIGLF VPKNDDVSGA FVTLRVFRVF RIFKFSRHSQ GLRILGYTLK SCASELGFLL FSLTMAIIIF ATVMFYAEKG TSKTNFTSIP AAFWYTIVTM TTLGYGDMVP STIAGKIFGS ICSLSGVLVI ALPVPVIVSN FSRIYHQNQR ADKRRAQQKV RLARIRLAKS GTTNAFLQYK QNGGLEDSGS GDGQMLCVRS RSAFEQQHHH LLHCLEKTTC HEFTDELTFS EALGAVSLGG RTSRSTSVSS QPMGPGSLFS SCCSRRVNRR AIRLANSTAS VSRGSMQELD TLAGLRRSPA PQTRSSLNAK PHDSLDLNCD SRDFVAAIIS IPTPPANTPD ESQPSSPSGG GGSGGTPNTT LRNSSLGTPC LLPETVKISS L //