ID A2AAX8_MOUSE Unreviewed; 182 AA. AC A2AAX8; DT 05-FEB-2008, integrated into UniProtKB/TrEMBL. DT 05-FEB-2008, sequence version 1. DT 02-OCT-2024, entry version 91. DE RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069}; DE AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069}; DE Flags: Fragment; GN Name=Nprl3 {ECO:0000313|Ensembl:ENSMUSP00000123219.2, GN ECO:0000313|MGI:MGI:109258}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000123219.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000123219.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123219.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000123219.2} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123219.2}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000123219.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123219.2}; RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC -!- FUNCTION: As a component of the GATOR1 complex functions as an CC inhibitor of the amino acid-sensing branch of the TORC1 pathway. CC {ECO:0000256|RuleBase:RU368069}. CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}. CC -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546, CC ECO:0000256|RuleBase:RU368069}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A2AAX8; -. DR SMR; A2AAX8; -. DR ProteomicsDB; 367344; -. DR Antibodypedia; 1565; 95 antibodies from 27 providers. DR Ensembl; ENSMUST00000129010.2; ENSMUSP00000123219.2; ENSMUSG00000020289.16. DR AGR; MGI:109258; -. DR MGI; MGI:109258; Nprl3. DR VEuPathDB; HostDB:ENSMUSG00000020289; -. DR GeneTree; ENSGT00390000015916; -. DR HOGENOM; CLU_1485329_0_0_1; -. DR ChiTaRS; Nprl3; mouse. DR Proteomes; UP000000589; Chromosome 11. DR Bgee; ENSMUSG00000020289; Expressed in hindlimb stylopod muscle and 159 other cell types or tissues. DR ExpressionAtlas; A2AAX8; baseline and differential. DR GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule. DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell. DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule. DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro. DR InterPro; IPR005365; Npr3. DR PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1. DR PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1. DR Pfam; PF03666; NPR3; 1. PE 1: Evidence at protein level; KW Lysosome {ECO:0000256|RuleBase:RU368069}; KW Proteomics identification {ECO:0007829|ProteomicsDB:A2AAX8}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|RuleBase:RU368069}. FT REGION 27..69 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 31..47 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 50..64 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 182 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000123219.2" SQ SEQUENCE 182 AA; 20213 MW; 9E7574532DB07F6E CRC64; MGDNTSPISV ILVSSGSRGN KLLFRYPFQR SQEHPASQTN KPRSRYAVNN TGEHADDQDG DSSKPCPPTD EQLVAGFSDV ILATILATKS EMCGQKFELK IDNVRFVGHP TLLQHALGQV SKTDPSPKRE APTMILFNVV FALRANADPS VINCLHNLSR RIATVLQHEE RRCQYLTREA KL //