ID A1XDS9_TOXGO Unreviewed; 116 AA. AC A1XDS9; A0A0N5ECT0; B6KKQ6; B9PTK0; B9QE61; S7W4C4; S8EX31; DT 06-FEB-2007, integrated into UniProtKB/TrEMBL. DT 06-FEB-2007, sequence version 1. DT 24-JUL-2024, entry version 92. DE RecName: Full=L-dopachrome isomerase {ECO:0000256|ARBA:ARBA00042730}; DE EC=5.3.2.1 {ECO:0000256|ARBA:ARBA00039086}; DE EC=5.3.3.12 {ECO:0000256|ARBA:ARBA00038932}; DE AltName: Full=L-dopachrome tautomerase {ECO:0000256|ARBA:ARBA00041631}; DE AltName: Full=Phenylpyruvate tautomerase {ECO:0000256|ARBA:ARBA00041912}; GN ORFNames=TGRH88_014810 {ECO:0000313|EMBL:KAF4644487.1}; OS Toxoplasma gondii. OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia; OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma. OX NCBI_TaxID=5811 {ECO:0000313|EMBL:ABC69140.1}; RN [1] {ECO:0000313|EMBL:ABC69140.1} RP NUCLEOTIDE SEQUENCE. RA Miska K.B., Fetterer R.H., Lillehoj H.S., Jenkins M.C., Allen P.C., RA Harper S.; RT "Characterization of macrophage migration inhibitory factor from Eimeria RT species infectious to chickens."; RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ACY01255.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=RH {ECO:0000313|EMBL:ACY01255.1}; RA Sommerville C., Roberts C.W., Alexander J., Henriquez F.L.; RT "Characterization of TgMIF."; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0007829|PDB:4DH4} RP X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) OF 2-115. RX PubMed=23443656; DOI=10.1074/jbc.m112.419911; RA Sommerville C., Richardson J.M., Williams R.A., Mottram J.C., Roberts C.W., RA Alexander J., Henriquez F.L.; RT "Biochemical and immunological characterization of Toxoplasma gondii RT macrophage migration inhibitory factor."; RL J. Biol. Chem. 288:12733-12741(2013). RN [4] {ECO:0000313|EMBL:KAF4644487.1, ECO:0000313|Proteomes:UP000557509} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RH-88 {ECO:0000313|EMBL:KAF4644487.1, RC ECO:0000313|Proteomes:UP000557509}; RA Lorenzi H.A., Venepally P., Rozenberg A., Sibley D.; RT "Genome sequence of Toxoplasma gondii RH-88 strain."; RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=3-phenylpyruvate = enol-phenylpyruvate; Xref=Rhea:RHEA:17097, CC ChEBI:CHEBI:16815, ChEBI:CHEBI:18005; EC=5.3.2.1; CC Evidence={ECO:0000256|ARBA:ARBA00036735}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-dopachrome = 5,6-dihydroxyindole-2-carboxylate; CC Xref=Rhea:RHEA:13041, ChEBI:CHEBI:16875, ChEBI:CHEBI:57509; CC EC=5.3.3.12; Evidence={ECO:0000256|ARBA:ARBA00036823}; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the MIF family. {ECO:0000256|ARBA:ARBA00005851}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ344450; ABC69140.1; -; mRNA. DR EMBL; GU071275; ACY01255.1; -; mRNA. DR EMBL; JAAUHK010000190; KAF4644487.1; -; Genomic_DNA. DR PDB; 4DH4; X-ray; 1.82 A; A=2-115. DR PDBsum; 4DH4; -. DR AlphaFoldDB; A1XDS9; -. DR SMR; A1XDS9; -. DR VEuPathDB; ToxoDB:TGARI_369230; -. DR VEuPathDB; ToxoDB:TGCAST_290040; -. DR VEuPathDB; ToxoDB:TGCOUG_290040; -. DR VEuPathDB; ToxoDB:TGDOM2_290040; -. DR VEuPathDB; ToxoDB:TGFOU_290040; -. DR VEuPathDB; ToxoDB:TGGT1_290040; -. DR VEuPathDB; ToxoDB:TGMAS_290040; -. DR VEuPathDB; ToxoDB:TGME49_290040; -. DR VEuPathDB; ToxoDB:TGP89_290040; -. DR VEuPathDB; ToxoDB:TGPRC2_290040; -. DR VEuPathDB; ToxoDB:TGRH88_014810; -. DR VEuPathDB; ToxoDB:TGRUB_290040; -. DR VEuPathDB; ToxoDB:TGVAND_290040; -. DR VEuPathDB; ToxoDB:TGVEG_290040; -. DR OMA; DRIYISY; -. DR EvolutionaryTrace; A1XDS9; -. DR Proteomes; UP000557509; Unassembled WGS sequence. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0050178; F:phenylpyruvate tautomerase activity; IEA:TreeGrafter. DR Gene3D; 3.30.429.10; Macrophage Migration Inhibitory Factor; 1. DR InterPro; IPR001398; Macrophage_inhib_fac. DR InterPro; IPR019829; Macrophage_inhib_fac_CS. DR InterPro; IPR014347; Tautomerase/MIF_sf. DR PANTHER; PTHR11954; D-DOPACHROME DECARBOXYLASE; 1. DR PANTHER; PTHR11954:SF6; MACROPHAGE MIGRATION INHIBITORY FACTOR; 1. DR Pfam; PF01187; MIF; 1. DR SUPFAM; SSF55331; Tautomerase/MIF; 1. DR PROSITE; PS01158; MIF; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:4DH4}; KW Cytokine {ECO:0000256|ARBA:ARBA00022514}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}. SQ SEQUENCE 116 AA; 12254 MW; 7D4EDCB7701E63E5 CRC64; MPKCMIFCPV AATPAQQDAL LKDAEKAVAD ALGKPLSYVM VGYSQTGQMR FGGSSDPCAF IRVASIGGIT SSTNCKIAAA LSAACERHLG VPKNRIYTTF TNKSPSEWAM GDRTFG //