ID IOLG2_PAEAT Reviewed; 332 AA. AC A1R674; DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot. DT 06-FEB-2007, sequence version 1. DT 28-JUN-2023, entry version 109. DE RecName: Full=Inositol 2-dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_01671}; DE EC=1.1.1.18 {ECO:0000255|HAMAP-Rule:MF_01671}; DE AltName: Full=Myo-inositol 2-dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_01671}; DE Short=MI 2-dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_01671}; GN Name=iolG2 {ECO:0000255|HAMAP-Rule:MF_01671}; OrderedLocusNames=AAur_1991; OS Paenarthrobacter aurescens (strain TC1). OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae; OC Paenarthrobacter. OX NCBI_TaxID=290340; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=TC1; RX PubMed=17194220; DOI=10.1371/journal.pgen.0020214; RA Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., RA Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., RA Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.; RT "Secrets of soil survival revealed by the genome sequence of Arthrobacter RT aurescens TC1."; RL PLoS Genet. 2:2094-2106(2006). CC -!- FUNCTION: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo- CC inositol (2KMI or 2-inosose). {ECO:0000255|HAMAP-Rule:MF_01671}. CC -!- CATALYTIC ACTIVITY: CC Reaction=myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose; CC Xref=Rhea:RHEA:16949, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268, CC ChEBI:CHEBI:17811, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.18; CC Evidence={ECO:0000255|HAMAP-Rule:MF_01671}; CC -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01671}. CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000255|HAMAP- CC Rule:MF_01671}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000474; ABM08382.1; -; Genomic_DNA. DR RefSeq; WP_011774680.1; NC_008711.1. DR AlphaFoldDB; A1R674; -. DR SMR; A1R674; -. DR STRING; 290340.AAur_1991; -. DR EnsemblBacteria; ABM08382; ABM08382; AAur_1991. DR KEGG; aau:AAur_1991; -. DR eggNOG; COG0673; Bacteria. DR HOGENOM; CLU_023194_0_1_11; -. DR OMA; MIGRDHL; -. DR OrthoDB; 256869at2; -. DR Proteomes; UP000000637; Chromosome. DR GO; GO:0050112; F:inositol 2-dehydrogenase activity; IEA:UniProtKB-UniRule. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0019310; P:inositol catabolic process; IEA:UniProtKB-UniRule. DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1. DR HAMAP; MF_01671; IolG; 1. DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C. DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N. DR InterPro; IPR023794; MI/DCI_dehydrogenase. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR PANTHER; PTHR42840:SF3; BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED; 1. DR PANTHER; PTHR42840; NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED; 1. DR Pfam; PF01408; GFO_IDH_MocA; 1. DR Pfam; PF02894; GFO_IDH_MocA_C; 1. DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1. DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1. PE 3: Inferred from homology; KW NAD; Oxidoreductase. FT CHAIN 1..332 FT /note="Inositol 2-dehydrogenase 2" FT /id="PRO_0000352552" SQ SEQUENCE 332 AA; 34727 MW; D86D3F17C1AF5CB7 CRC64; MPIRVGVIGA GVMGADHIRN LSTTIGGAKV TFVADLDAGR AAAAAPPSAR ITTDPTELIN SSDVDAVVVA SHDSTHAGLV LECFEAMTPV LCEKPLAPTL LESLEVVAAD ADIVAATGAS LLSLGFMRRF DPGYVALRQA VQGRVQGEPL MVHCVSRNAA AGPGTTSELA ITNSAIHELD IIPWLLGSPV TEVSWQAGKQ TSRAEPGLQD PSFMTLRTAD GTLTTLELYL NAQYGYTTRC EVVSEQGTTS LQESSLLGIE QDGTRQAVIP ADWRPRFADA YRLQLQAWIS ALAGGEAPSL AGAQDGLNAS LVAQAMIQSL HSDGTTTKVS YS //