ID A1R450_ARTAT Unreviewed; 430 AA. AC A1R450; DT 06-FEB-2007, integrated into UniProtKB/TrEMBL. DT 06-FEB-2007, sequence version 1. DT 05-MAY-2009, entry version 26. DE RecName: Full=Serine hydroxymethyltransferase; DE EC=2.1.2.1; GN Name=glyA; OrderedLocusNames=AAur_1227; OS Arthrobacter aurescens (strain TC1). OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Micrococcineae; Micrococcaceae; Arthrobacter. OX NCBI_TaxID=290340; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17194220; DOI=10.1371/journal.pgen.0020214; RA Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., RA Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., RA Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.; RT "Secrets of soil survival revealed by the genome sequence of RT Arthrobacter aurescens TC1."; RL PLoS Genet. 2:2094-2106(2006). CC -!- FUNCTION: Interconversion of serine and glycine (By similarity). CC -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + glycine + CC H(2)O = tetrahydrofolate + L-serine. CC -!- COFACTOR: Pyridoxal phosphate (By similarity). CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate pathway. CC -!- SIMILARITY: Belongs to the SHMT family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000474; ABM08285.1; -; Genomic_DNA. DR RefSeq; YP_947012.1; -. DR GeneID; 4641158; -. DR GenomeReviews; CP000474_GR; AAur_1227. DR KEGG; aau:AAur_1227; -. DR TIGR; AAur_1227; -. DR OMA; A1R450; VAAYQVE. DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:InterPro. DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. DR GO; GO:0006544; P:glycine metabolic process; IEA:InterPro. DR GO; GO:0006563; P:L-serine metabolic process; IEA:InterPro. DR GO; GO:0006730; P:one-carbon compound metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR001085; Gly_HO-MeTrfase. DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1. DR Gene3D; G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 1. DR PANTHER; PTHR11680; Gly_HO-Metrfase; 1. DR Pfam; PF00464; SHMT; 1. DR PIRSF; PIRSF000412; SHMT; 1. DR PROSITE; PS00096; SHMT; 1. PE 3: Inferred from homology; KW Complete proteome; Methyltransferase; One-carbon metabolism; KW Pyridoxal phosphate; Transferase. SQ SEQUENCE 430 AA; 46054 MW; C477D9DDA44314E8 CRC64; MTTTTSASVS NQSLADLDPE IAAVLNQELG RQRGTLEMIA SENFAPRAVM EAQGSVLTNK YAEGYPGRRY YGGCEYVDVA EQLAIDRVKE LFGAEYANVQ PHSGAQANAA ALSAMITPGD KILGLSLAHG GHLTHGMKLN FSGKLYNVAA YQVEEDNFRI DMDKLREQAI AEKPQVIIAG WSAYPRHLDF AAFRSIADEV GALLWTDMAH FAGLVAAGLH PSPVPHSDVV TSTVHKTLAG PRSGVILGKQ EWAKKLNSSV FPGQQGGPLM HVIAAKAVAF KIAGGEEFKE RQERVLEGAR IIADRLNQSD VAEAGVSVLT GGTDVHLVLV DLRNSQLDGQ QAEDLLHSVG ITVNRNAVPF DPRPPMVTSG LRIGTPALAT RGFGATEFTE VAEIIATALK AGSSADVESL QARVDKLAAD FPLYPQHEQW //