ID A1L1P2_DANRE Unreviewed; 717 AA. AC A1L1P2; DT 06-FEB-2007, integrated into UniProtKB/TrEMBL. DT 06-FEB-2007, sequence version 1. DT 09-DEC-2015, entry version 70. DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815}; GN Name=dld {ECO:0000313|EMBL:AAI29160.1, GN ECO:0000313|ZFIN:ZDB-GENE-990415-47}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI29160.1}; RN [1] {ECO:0000313|EMBL:AAI29160.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Embryo {ECO:0000313|EMBL:AAI29160.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch CC signaling. {ECO:0000256|RuleBase:RU280815}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280815}; CC Single-pass type I membrane protein CC {ECO:0000256|RuleBase:RU280815}. CC -!- SIMILARITY: Contains 1 DSL domain. CC {ECO:0000256|RuleBase:RU280815}. CC -!- SIMILARITY: Contains 8 EGF-like domains. CC {ECO:0000256|RuleBase:RU280815}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC129159; AAI29160.1; -; mRNA. DR RefSeq; NP_571030.2; NM_130955.2. DR UniGene; Dr.75102; -. DR ProteinModelPortal; A1L1P2; -. DR STRING; 7955.ENSDARP00000089996; -. DR PaxDb; A1L1P2; -. DR GeneID; 30138; -. DR KEGG; dre:30138; -. DR CTD; 1738; -. DR ZFIN; ZDB-GENE-990415-47; dld. DR eggNOG; ENOG410IR7B; Eukaryota. DR eggNOG; ENOG410XUNS; LUCA. DR HOVERGEN; HBG007139; -. DR KO; K06051; -. DR NextBio; 20806614; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro. DR InterPro; IPR001774; DSL. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_N_dom. DR InterPro; IPR011651; Notch_ligand_N. DR Pfam; PF01414; DSL; 1. DR Pfam; PF00008; EGF; 5. DR Pfam; PF07657; MNNL; 1. DR SMART; SM00051; DSL; 1. DR SMART; SM00181; EGF; 4. DR SMART; SM00179; EGF_CA; 4. DR SUPFAM; SSF57184; SSF57184; 1. DR PROSITE; PS00010; ASX_HYDROXYL; 3. DR PROSITE; PS51051; DSL; 1. DR PROSITE; PS00022; EGF_1; 8. DR PROSITE; PS01186; EGF_2; 8. DR PROSITE; PS50026; EGF_3; 8. DR PROSITE; PS01187; EGF_CA; 2. PE 2: Evidence at transcript level; KW Developmental protein {ECO:0000256|RuleBase:RU280815}; KW Disulfide bond {ECO:0000256|RuleBase:RU280815, KW ECO:0000256|SAAS:SAAS00033343}; KW EGF-like domain {ECO:0000256|RuleBase:RU000459, KW ECO:0000256|SAAS:SAAS00032677}; KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius}; KW Repeat {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAAS:SAAS00296558}; KW Signal {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|RuleBase:RU280815, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|RuleBase:RU280815, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 717 Delta-like protein. {ECO:0000256|SAM: FT SignalP}. FT /FTId=PRO_5002635839. FT TRANSMEM 544 570 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 175 219 DSL. {ECO:0000259|PROSITE:PS51051}. FT DOMAIN 220 253 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 257 284 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 286 324 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 326 362 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 364 401 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 403 439 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 441 477 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 479 515 EGF-like. {ECO:0000259|PROSITE:PS50026}. SQ SEQUENCE 717 AA; 78971 MW; D599476052EFE60F CRC64; MGRLMIAVLL CVMISQGFCS GVFELKLQEF LNKKGVTGNA NCCKGSAAEG LQCECKTFFR ICLKHYQANV SPDPPCTYGG AVTPVLGSNS FQVPESFPDS SFTNPIPFAF GFTWPGTFSL IIEALHTDST DDLSTENPDR LISRMTTQRH LTVGEEWSQD LQVGGRTELK YSYRFVCDEH YYGEGCSVFC RPRDDTFGHF TCGERGEIIC NSGWKGQYCT EPICLPGCDE DHGFCDKPGE CKCRVGFSGK YCDDCIRYPG CLHGTCQQPW QCNCQEGWGG LFCNQDLNYC THHKPCQNGA TCTNTGQGSY TCSCRPGFTG DSCEIEVNEC SGSPCRNGGS CTDLENTYSC TCPPGFYGRN CELSAMTCAD GPCFNGGQCA DNPEGGYFCQ CPMGYAGFNC EKKIDHCSSN PCSNDAQCLD LVDSYLCQCP EGFTGTHCED NIDECATYPC QNGGTCQDGL SDYTCTCPPG YTGKNCTSAV NKCLHNPCHN GATCHEMDGR YVCACIPGYG GRNCQFLLPE NPQGQAIVEG ADKRYSYEED DGGFPWTAVC AGIILVLLVL IGGSVFVIYI RLKLQQRSQQ IDSHSEIETM NNLTNNRSRE KDLSVSIIGA TQVKNINKKV DFQSDGDKNG FKSRYSLVDY NLVHELKQED LGKEDSERSE ATKCEPLDSD SEEKHRNHLK SDSSERKRTE SLCKDTKYQS VFVLSEEKDE CIIATEV //