ID A1L1P2_DANRE Unreviewed; 717 AA. AC A1L1P2; DT 06-FEB-2007, integrated into UniProtKB/TrEMBL. DT 06-FEB-2007, sequence version 1. DT 07-APR-2021, entry version 100. DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815}; GN Name=dld {ECO:0000313|EMBL:AAI29160.1, GN ECO:0000313|ZFIN:ZDB-GENE-990415-47}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI29160.1}; RN [1] {ECO:0000313|EMBL:AAI29160.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Embryo {ECO:0000313|EMBL:AAI29160.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch CC signaling. {ECO:0000256|RuleBase:RU280815}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479, CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC129159; AAI29160.1; -; mRNA. DR RefSeq; NP_571030.2; NM_130955.2. DR DNASU; 30138; -. DR GeneID; 30138; -. DR KEGG; dre:30138; -. DR CTD; 1738; -. DR ZFIN; ZDB-GENE-990415-47; dld. DR OMA; DKPCHQG; -. DR OrthoDB; 406049at2759; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW. DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro. DR InterPro; IPR001774; DSL. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR011651; Notch_ligand_N. DR Pfam; PF01414; DSL; 1. DR Pfam; PF00008; EGF; 5. DR Pfam; PF12661; hEGF; 1. DR Pfam; PF07657; MNNL; 1. DR SMART; SM00051; DSL; 1. DR SMART; SM00181; EGF; 8. DR SMART; SM00179; EGF_CA; 6. DR SUPFAM; SSF57184; SSF57184; 1. DR PROSITE; PS00010; ASX_HYDROXYL; 3. DR PROSITE; PS51051; DSL; 1. DR PROSITE; PS00022; EGF_1; 8. DR PROSITE; PS01186; EGF_2; 7. DR PROSITE; PS50026; EGF_3; 8. DR PROSITE; PS01187; EGF_CA; 2. PE 2: Evidence at transcript level; KW Developmental protein {ECO:0000256|RuleBase:RU280815}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE- KW ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE- KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius}; KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815}; KW Signal {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|RuleBase:RU280815, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..717 FT /note="Delta-like protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5002635839" FT TRANSMEM 544..570 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 175..219 FT /note="DSL" FT /evidence="ECO:0000259|PROSITE:PS51051" FT DOMAIN 220..253 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 257..284 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 286..324 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 326..362 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 364..401 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 403..439 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 441..477 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 479..515 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT REGION 649..693 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 177..186 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377" FT DISULFID 190..202 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377" FT DISULFID 210..219 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377" FT DISULFID 243..252 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 274..283 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 314..323 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 352..361 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 391..400 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 429..438 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 467..476 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 505..514 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" SQ SEQUENCE 717 AA; 78971 MW; D599476052EFE60F CRC64; MGRLMIAVLL CVMISQGFCS GVFELKLQEF LNKKGVTGNA NCCKGSAAEG LQCECKTFFR ICLKHYQANV SPDPPCTYGG AVTPVLGSNS FQVPESFPDS SFTNPIPFAF GFTWPGTFSL IIEALHTDST DDLSTENPDR LISRMTTQRH LTVGEEWSQD LQVGGRTELK YSYRFVCDEH YYGEGCSVFC RPRDDTFGHF TCGERGEIIC NSGWKGQYCT EPICLPGCDE DHGFCDKPGE CKCRVGFSGK YCDDCIRYPG CLHGTCQQPW QCNCQEGWGG LFCNQDLNYC THHKPCQNGA TCTNTGQGSY TCSCRPGFTG DSCEIEVNEC SGSPCRNGGS CTDLENTYSC TCPPGFYGRN CELSAMTCAD GPCFNGGQCA DNPEGGYFCQ CPMGYAGFNC EKKIDHCSSN PCSNDAQCLD LVDSYLCQCP EGFTGTHCED NIDECATYPC QNGGTCQDGL SDYTCTCPPG YTGKNCTSAV NKCLHNPCHN GATCHEMDGR YVCACIPGYG GRNCQFLLPE NPQGQAIVEG ADKRYSYEED DGGFPWTAVC AGIILVLLVL IGGSVFVIYI RLKLQQRSQQ IDSHSEIETM NNLTNNRSRE KDLSVSIIGA TQVKNINKKV DFQSDGDKNG FKSRYSLVDY NLVHELKQED LGKEDSERSE ATKCEPLDSD SEEKHRNHLK SDSSERKRTE SLCKDTKYQS VFVLSEEKDE CIIATEV //