ID MMM1_ASPCL Reviewed; 494 AA. AC A1CM86; DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 1. DT 07-JAN-2015, entry version 34. DE RecName: Full=Maintenance of mitochondrial morphology protein 1 {ECO:0000255|HAMAP-Rule:MF_03103}; GN Name=mmm1; ORFNames=ACLA_096060; OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC OS 3887 / NRRL 1). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus. OX NCBI_TaxID=344612; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1; RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046; RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., RA Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., RA Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., RA Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R., RA Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., RA Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., RA Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., RA Jiang B., Denning D.W., Nierman W.C.; RT "Genomic islands in the pathogenic filamentous fungus Aspergillus RT fumigatus."; RL PLoS Genet. 4:E1000046-E1000046(2008). CC -!- FUNCTION: Component of the ERMES/MDM complex, which serves as a CC molecular tether to connect the endoplasmic reticulum and CC mitochondria. Components of this complex are involved in the CC control of mitochondrial shape and protein biogenesis and may CC function in phospholipid exchange. The mdm12-mmm1 subcomplex CC functions in the major beta-barrel assembly pathway that is CC responsible for biogenesis of all outer membrane beta-barrel CC proteins, and acts in a late step after the SAM complex. The CC mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific CC pathway after the action of the mdm12-mmm1 complex. Essential for CC establishing and maintaining the structure of mitochondria and CC maintenance of mtDNA nucleoids. {ECO:0000255|HAMAP-Rule:MF_03103}. CC -!- SUBUNIT: Component of the ER-mitochondria encounter structure CC (ERMES) or MDM complex, composed of mmm1, mdm10, mdm12 and mdm34. CC {ECO:0000255|HAMAP-Rule:MF_03103}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000255|HAMAP-Rule:MF_03103}; Single-pass type I membrane CC protein {ECO:0000255|HAMAP-Rule:MF_03103}. Note=The ERMES/MDM CC complex localizes to a few discrete foci (around 10 per single CC cell), that represent mitochondria-endoplasmic reticulum CC junctions. These foci are often found next to mtDNA nucleoids. CC {ECO:0000255|HAMAP-Rule:MF_03103}. CC -!- SIMILARITY: Belongs to the MMM1 family. {ECO:0000255|HAMAP- CC Rule:MF_03103}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DS027058; EAW08673.1; -; Genomic_DNA. DR RefSeq; XP_001270099.1; XM_001270098.1. DR STRING; 5057.CADACLAP00008765; -. DR EnsemblFungi; CADACLAT00008989; CADACLAP00008765; CADACLAG00008989. DR GeneID; 4702260; -. DR KEGG; act:ACLA_096060; -. DR eggNOG; NOG79949; -. DR HOGENOM; HOG000201075; -. DR KO; K17764; -. DR OMA; ERCVEPR; -. DR OrthoDB; EOG7J9VZZ; -. DR Proteomes; UP000006701; Unassembled WGS sequence. DR GO; GO:0032865; C:ERMES complex; IEA:UniProtKB-HAMAP. DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IEA:UniProtKB-HAMAP. DR GO; GO:0000002; P:mitochondrial genome maintenance; IEA:UniProtKB-HAMAP. DR GO; GO:0045040; P:protein import into mitochondrial outer membrane; IEA:UniProtKB-HAMAP. DR HAMAP; MF_03103; Mmm1; 1. DR InterPro; IPR019411; DUF2404. DR InterPro; IPR027537; Mmm1. DR Pfam; PF10296; DUF2404; 1. PE 3: Inferred from homology; KW Complete proteome; Endoplasmic reticulum; Membrane; KW Reference proteome; Transmembrane; Transmembrane helix. FT CHAIN 1 494 Maintenance of mitochondrial morphology FT protein 1. FT /FTId=PRO_0000384212. FT TOPO_DOM 1 22 Lumenal. {ECO:0000255|HAMAP- FT Rule:MF_03103}. FT TRANSMEM 23 43 Helical. {ECO:0000255|HAMAP- FT Rule:MF_03103}. FT TOPO_DOM 44 494 Cytoplasmic. {ECO:0000255|HAMAP- FT Rule:MF_03103}. SQ SEQUENCE 494 AA; 53099 MW; 283DF95B427E2274 CRC64; MSSQPGDPAT LPAQSSLSFT QGFLLGQLSV VLVLAAFIKF FIFGEAPPPP SRGLSHRSAT HRRSNSIYSN SPQEAGSRSL REKPSTSNVL RPVPSSSTNT RSILRKTYYS AIPTNPAKHG RLRIHHSSHQ PESLDWFNVL IAQTIAQYRQ TAYSLKDSPT SSILNSLTAA LNNPEKKPAF IDKITVTDIS LGEEFPIFSN CRIIAVDDPN SDGGRLQALM DVDLSDDNLS IAIETQLLLN YPKPCSAILP VALSISVVRF SGTLCISLVP ASTPPLDTPS HSPSPPTADT ATSGRSKPGD KAGGNQPRSN GSTEDPAGGN PPKTSPKSNV AFSFLPDYRL DLSVRSLIGS RSRLQDVPKV AQLVEARVQA WFEERVVEPR VQVVGLPDLW PRMGRTGVRT GDDAETASNG PRSTVSADIG GSARHEELAR EPEALRFRGL LGARPPFDVA SRTSSFNVET GDLRSRSMTR QESSGDLSDQ LHIPGSLPEA VTPG //