ID A1A703_DROME Unreviewed; 614 AA. AC A1A703; DT 23-JAN-2007, integrated into UniProtKB/TrEMBL. DT 23-JAN-2007, sequence version 1. DT 30-AUG-2017, entry version 97. DE SubName: Full=IP17340p {ECO:0000313|EMBL:ABL75733.1}; DE SubName: Full=IP17540p {ECO:0000313|EMBL:ABL75772.1}; DE SubName: Full=SNF4/AMP-activated protein kinase gamma subunit, isoform M {ECO:0000313|EMBL:ABW08716.1}; DE SubName: Full=SNF4/AMP-activated protein kinase gamma subunit, isoform N {ECO:0000313|EMBL:ABW08717.1}; DE EC=2.7.11.- {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|EMBL:ABW08716.1, ECO:0000313|EMBL:ABW08717.1}; DE SubName: Full=SNF4/AMP-activated protein kinase gamma subunit, isoform O {ECO:0000313|EMBL:ABI31187.2}; GN Name=SNF4Agamma {ECO:0000313|EMBL:ABL75733.1, GN ECO:0000313|FlyBase:FBgn0264357}; GN ORFNames=CG17299 {ECO:0000313|FlyBase:FBgn0264357}, Dmel_CG17299 GN {ECO:0000313|EMBL:ABI31187.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ABL75733.1}; RN [1] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:ABI31187.2} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:ABI31187.2} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:ABL75733.1} RP NUCLEOTIDE SEQUENCE. RA Stapleton M., Carlson J., Frise E., Kapadia B., Park S., Wan K., RA Yu C., Celniker S.; RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [11] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] {ECO:0000313|EMBL:ABI31187.2} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; ABI31187.2; -; Genomic_DNA. DR EMBL; BT029676; ABL75733.1; -; mRNA. DR EMBL; BT029715; ABL75772.1; -; mRNA. DR EMBL; AE014297; ABW08716.1; -; Genomic_DNA. DR EMBL; AE014297; ABW08717.1; -; Genomic_DNA. DR RefSeq; NP_001036736.2; NM_001043271.3. DR RefSeq; NP_001097854.1; NM_001104384.3. DR RefSeq; NP_001097855.1; NM_001104385.2. DR UniGene; Dm.16656; -. DR SMR; A1A703; -. DR EnsemblMetazoa; FBtr0112915; FBpp0111828; FBgn0264357. DR EnsemblMetazoa; FBtr0112916; FBpp0111829; FBgn0264357. DR EnsemblMetazoa; FBtr0301585; FBpp0290800; FBgn0264357. DR GeneID; 42515; -. DR KEGG; dme:Dmel_CG17299; -. DR UCSC; CG17299-RM; d. melanogaster. DR CTD; 42515; -. DR FlyBase; FBgn0264357; SNF4Agamma. DR eggNOG; KOG1764; Eukaryota. DR eggNOG; COG0517; LUCA. DR GeneTree; ENSGT00390000009849; -. DR KO; K07200; -. DR OrthoDB; EOG091G0CZV; -. DR Reactome; R-DME-1632852; Macroautophagy. DR Reactome; R-DME-163680; AMPK inhibits chREBP transcriptional activation activity. DR Reactome; R-DME-200425; Import of palmitoyl-CoA into the mitochondrial matrix. DR Reactome; R-DME-380972; Energy dependent regulation of mTOR by LKB1-AMPK. DR Reactome; R-DME-5628897; TP53 Regulates Metabolic Genes. DR ChiTaRS; SNF4Agamma; fly. DR GenomeRNAi; 42515; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0264357; -. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW. DR GO; GO:0019901; F:protein kinase binding; ISS:FlyBase. DR GO; GO:0006914; P:autophagy; IMP:FlyBase. DR GO; GO:0042595; P:behavioral response to starvation; IMP:FlyBase. DR GO; GO:0009267; P:cellular response to starvation; IMP:FlyBase. DR GO; GO:0042632; P:cholesterol homeostasis; IMP:FlyBase. DR GO; GO:0006629; P:lipid metabolic process; IMP:FlyBase. DR GO; GO:0045787; P:positive regulation of cell cycle; IGI:FlyBase. DR GO; GO:0010906; P:regulation of glucose metabolic process; IMP:FlyBase. DR GO; GO:2001020; P:regulation of response to DNA damage stimulus; IGI:FlyBase. DR GO; GO:0030730; P:sequestering of triglyceride; IMP:FlyBase. DR InterPro; IPR000644; CBS_dom. DR Pfam; PF00571; CBS; 3. DR SMART; SM00116; CBS; 4. DR PROSITE; PS51371; CBS; 4. PE 2: Evidence at transcript level; KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Kinase {ECO:0000313|EMBL:ABI31187.2}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transferase {ECO:0000313|EMBL:ABI31187.2}. FT DOMAIN 152 214 CBS. {ECO:0000259|PROSITE:PS51371}. FT DOMAIN 231 291 CBS. {ECO:0000259|PROSITE:PS51371}. FT DOMAIN 306 366 CBS. {ECO:0000259|PROSITE:PS51371}. FT DOMAIN 377 437 CBS. {ECO:0000259|PROSITE:PS51371}. SQ SEQUENCE 614 AA; 67801 MW; 3C4AE04CE010B062 CRC64; MSAVKRWIYR HTHSSSSATP TSPGPPPVSP TNKTRRGRSH SLDVQSLPGI RAMMVNSRAA AHQQQLAVQS AHMRRASADL EKRRASVGAA GRGLRGDGTL DPHHAAILFR DSRGLPVADP FLEKVNLSDL EEDDSQIFVK FFRFHKCYDL IPTSAKLVVF DTQLLVKKAF YALVYNGVRA APLWDSEKQQ FVGMLTITDF IKILQMYYKS PNASMEQLEE HKLDTWRSVL HNQVMPLVSI GPDASLYDAI KILIHSRIHR LPVIDPATGN VLYILTHKRI LRFLFLYINE LPKPAYMQKS LRELKIGTYN NIETADETTS IITALKKFVE RRVSALPLVD SDGRLVDIYA KFDVINLAAE KTYNDLDVSL RKANEHRNEW FEGVQKCNLD ESLYTIMERI VRAEVHRLVV VDENRKVIGI ISLSDILLYL VLRPSGEGVG GSESSLRASD PVLLRKVAEV EIPATAAAAT TTTPPRSPSA GSGNRSLIED IPEEETAPAR SDDADSDNNK SASEDKANNN QHDQTTTAAT ANGDSNNSPV EVSFADEAQE EEAADQVERS NCDDDDQPAL AEIERKNASM DDDEDDGMSS AVSAASALGQ SLTPAAQEMA LVSE //