ID A1A703_DROME Unreviewed; 614 AA. AC A1A703; DT 23-JAN-2007, integrated into UniProtKB/TrEMBL. DT 23-JAN-2007, sequence version 1. DT 07-JAN-2015, entry version 68. DE SubName: Full=IP17340p {ECO:0000313|EMBL:ABL75733.1}; DE SubName: Full=IP17540p {ECO:0000313|EMBL:ABL75772.1}; DE SubName: Full=SNF4/AMP-activated protein kinase gamma subunit, isoform M {ECO:0000313|EMBL:ABW08716.1}; DE EC=2.7.11.- {ECO:0000313|EMBL:ABW08716.1}; DE SubName: Full=SNF4/AMP-activated protein kinase gamma subunit, isoform N {ECO:0000313|EMBL:ABW08717.1}; DE EC=2.7.11.- {ECO:0000313|EMBL:ABW08717.1}; DE SubName: Full=SNF4/AMP-activated protein kinase gamma subunit, isoform O {ECO:0000313|EMBL:ABI31187.2}; DE EC=2.7.11.- {ECO:0000313|EMBL:ABI31187.2}; GN Name=SNF4Agamma {ECO:0000313|EMBL:ABL75733.1, GN ECO:0000313|FlyBase:FBgn0264357}; GN ORFNames=CG17299 {ECO:0000313|FlyBase:FBgn0264357}, Dmel_CG17299 GN {ECO:0000313|EMBL:ABI31187.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ABL75733.1}; RN [1] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:ABI31187.2} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:ABI31187.2} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:ABL75733.1} RP NUCLEOTIDE SEQUENCE. RA Stapleton M., Carlson J., Frise E., Kapadia B., Park S., Wan K., RA Yu C., Celniker S.; RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [11] {ECO:0000313|EMBL:ABI31187.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] {ECO:0000313|EMBL:ABI31187.2} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014297; ABI31187.2; -; Genomic_DNA. DR EMBL; BT029676; ABL75733.1; -; mRNA. DR EMBL; BT029715; ABL75772.1; -; mRNA. DR EMBL; AE014297; ABW08716.1; -; Genomic_DNA. DR EMBL; AE014297; ABW08717.1; -; Genomic_DNA. DR RefSeq; NP_001036736.2; NM_001043271.3. DR RefSeq; NP_001097854.1; NM_001104384.3. DR RefSeq; NP_001097855.1; NM_001104385.2. DR UniGene; Dm.16656; -. DR SMR; A1A703; 137-432. DR EnsemblMetazoa; FBtr0112915; FBpp0111828; FBgn0264357. DR EnsemblMetazoa; FBtr0112916; FBpp0111829; FBgn0264357. DR EnsemblMetazoa; FBtr0301585; FBpp0290800; FBgn0264357. DR GeneID; 42515; -. DR KEGG; dme:Dmel_CG17299; -. DR UCSC; CG17299-RM; d. melanogaster. DR CTD; 42515; -. DR FlyBase; FBgn0264357; SNF4Agamma. DR GeneTree; ENSGT00390000009849; -. DR OrthoDB; EOG74FF0W; -. DR Reactome; REACT_180852; Translocation of GLUT4 to the plasma membrane. DR Reactome; REACT_203135; Activation of PPARGC1A (PGC-1alpha) by phosphorylation. DR Reactome; REACT_214462; Import of palmitoyl-CoA into the mitochondrial matrix. DR Reactome; REACT_218224; AMPK inhibits chREBP transcriptional activation activity. DR Reactome; REACT_254010; Regulation of Rheb GTPase activity by AMPK. DR Reactome; REACT_259785; Regulation of AMPK activity via LKB1. DR ChiTaRS; SNF4Agamma; fly. DR GenomeRNAi; 42515; -. DR NextBio; 829192; -. DR Proteomes; UP000000803; Chromosome 3R. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; IDA:FlyBase. DR GO; GO:0030554; F:adenyl nucleotide binding; IEA:InterPro. DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW. DR GO; GO:0006914; P:autophagy; IMP:FlyBase. DR GO; GO:0042595; P:behavioral response to starvation; IMP:FlyBase. DR GO; GO:0009267; P:cellular response to starvation; IMP:FlyBase. DR GO; GO:0042632; P:cholesterol homeostasis; IMP:FlyBase. DR GO; GO:0006629; P:lipid metabolic process; IMP:FlyBase. DR GO; GO:0045787; P:positive regulation of cell cycle; IGI:FlyBase. DR GO; GO:2001020; P:regulation of response to DNA damage stimulus; IGI:FlyBase. DR GO; GO:0030730; P:sequestering of triglyceride; IMP:FlyBase. DR InterPro; IPR000644; CBS_dom. DR Pfam; PF00571; CBS; 4. DR SMART; SM00116; CBS; 4. DR PROSITE; PS51371; CBS; 4. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Kinase {ECO:0000313|EMBL:ABI31187.2}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transferase {ECO:0000313|EMBL:ABI31187.2}. SQ SEQUENCE 614 AA; 67801 MW; 3C4AE04CE010B062 CRC64; MSAVKRWIYR HTHSSSSATP TSPGPPPVSP TNKTRRGRSH SLDVQSLPGI RAMMVNSRAA AHQQQLAVQS AHMRRASADL EKRRASVGAA GRGLRGDGTL DPHHAAILFR DSRGLPVADP FLEKVNLSDL EEDDSQIFVK FFRFHKCYDL IPTSAKLVVF DTQLLVKKAF YALVYNGVRA APLWDSEKQQ FVGMLTITDF IKILQMYYKS PNASMEQLEE HKLDTWRSVL HNQVMPLVSI GPDASLYDAI KILIHSRIHR LPVIDPATGN VLYILTHKRI LRFLFLYINE LPKPAYMQKS LRELKIGTYN NIETADETTS IITALKKFVE RRVSALPLVD SDGRLVDIYA KFDVINLAAE KTYNDLDVSL RKANEHRNEW FEGVQKCNLD ESLYTIMERI VRAEVHRLVV VDENRKVIGI ISLSDILLYL VLRPSGEGVG GSESSLRASD PVLLRKVAEV EIPATAAAAT TTTPPRSPSA GSGNRSLIED IPEEETAPAR SDDADSDNNK SASEDKANNN QHDQTTTAAT ANGDSNNSPV EVSFADEAQE EEAADQVERS NCDDDDQPAL AEIERKNASM DDDEDDGMSS AVSAASALGQ SLTPAAQEMA LVSE //