ID A0T1V1_9SAUR Unreviewed; 343 AA. AC A0T1V1; DT 09-JAN-2007, integrated into UniProtKB/TrEMBL. DT 09-JAN-2007, sequence version 1. DT 05-OCT-2016, entry version 47. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093744}; DE EC=1.6.5.3 {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093728}; GN Name=ND2 {ECO:0000313|EMBL:ABK63247.1}; OS Orthriophis taeniurus (beauty snake). OG Mitochondrion {ECO:0000313|EMBL:ABK63247.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; OC Toxicofera; Serpentes; Colubroidea; Colubridae; Colubrinae; OC Orthriophis. OX NCBI_TaxID=74398 {ECO:0000313|EMBL:ABK63247.1}; RN [1] {ECO:0000313|EMBL:ABK63247.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=17113316; DOI=10.1016/j.ympev.2006.09.009; RA Burbrink F.T., Lawson R.; RT "How and when did Old World ratsnakes disperse into the New World?"; RL Mol. Phylogenet. Evol. 43:173-189(2007). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|SAAS:SAAS00093760}. CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + CC ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS00093735}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00093751}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU003403, CC ECO:0000256|SAAS:SAAS00093751}. CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. CC {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00573211}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AH015912; ABK63247.1; -; Genomic_DNA. DR HOVERGEN; HBG016692; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro. DR InterPro; IPR010933; NADH_DH_su2_C. DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2. DR InterPro; IPR001750; ND/Mrp_mem. DR Pfam; PF06444; NADH_dehy_S2_C; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01436; NADHDHGNASE2. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|SAAS:SAAS00464461}; KW Membrane {ECO:0000256|SAAS:SAAS00464716, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464403, ECO:0000313|EMBL:ABK63247.1}; KW Mitochondrion inner membrane {ECO:0000256|SAAS:SAAS00464436}; KW NAD {ECO:0000256|RuleBase:RU003403, ECO:0000256|SAAS:SAAS00464384}; KW Oxidoreductase {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464503}; KW Respiratory chain {ECO:0000256|SAAS:SAAS00464594}; KW Transmembrane {ECO:0000256|SAAS:SAAS00464491, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00464584, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00464711}; KW Ubiquinone {ECO:0000256|RuleBase:RU003403, KW ECO:0000256|SAAS:SAAS00464648}. FT TRANSMEM 6 33 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 93 115 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 151 171 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 200 219 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 240 261 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 273 293 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 24 288 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. FT DOMAIN 290 343 NADH_dehy_S2_C. {ECO:0000259|Pfam: FT PF06444}. SQ SEQUENCE 343 AA; 38232 MW; ACF358B942ACF1AB CRC64; MNLTSWSIIT TSIILSTTMI TSTTHWLMTW VCLEINTLSM IPLISKPNHP RATEAATKYY LTQTMASTTI LFAATTNALS TSNWDMHLMT EPVATTITTM ALMMKMAAAP FHFWLPDVSQ GTTTLTALTI LTWQKIAPLT IMLTTHNKTN ITLMLLSAVL SITAGGLGSL NQTQLRKLMA FSSIAHTGWI MATMTMAPNI SMLTFMIYIT ATTPMFLLMN TTNSMTIKDI GTMWTNSPHI MMISLTTILS LGGLPPLSGF MPKWLILNNM TTMNMIVEAT LMTMTSLLSL YVYMRLMYMS SMTLPPHTTL TSLKWRTQNK KHRMTTSTMA MITMLMLPLS PNM //