ID   ACPS_MYCS2              Reviewed;         130 AA.
AC   A0R1H6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   01-SEP-2009, entry version 23.
DE   RecName: Full=Holo-[acyl-carrier-protein] synthase;
DE            Short=Holo-ACP synthase;
DE            EC=2.7.8.7;
DE   AltName: Full=4'-phosphopantetheinyl transferase acpS;
GN   Name=acpS; OrderedLocusNames=MSMEG_4756;
OS   Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION [LARGE SCALE ANALYSIS] BY MASS SPECTROMETRY, AND
RP   CLEAVAGE OF INITIATOR METHIONINE.
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through
RT   orthology and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
CC   -!- FUNCTION: Transfers the 4'-phosphopantetheine moiety from coenzyme
CC       A to a Ser of acyl-carrier-protein (By similarity).
CC   -!- CATALYTIC ACTIVITY: CoA-(4'-phosphopantetheine) + apo-[acyl-
CC       carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-
CC       carrier-protein].
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the P-Pant transferase superfamily. AcpS
CC       family.
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DR   EMBL; CP000480; ABK75003.1; -; Genomic_DNA.
DR   RefSeq; YP_889014.1; -.
DR   STRING; A0R1H6; -.
DR   GeneID; 4536674; -.
DR   GenomeReviews; CP000480_GR; MSMEG_4756.
DR   KEGG; msm:MSMEG_4756; -.
DR   NMPDR; fig|246196.1.peg.4746; -.
DR   TIGR; MSMEG_4756; -.
DR   OMA; A0R1H6; MISIGTD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008897; F:holo-[acyl-carrier-protein] synthase activity; IEA:HAMAP.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:HAMAP.
DR   GO; GO:0009059; P:macromolecule biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00101; -; 1.
DR   InterPro; IPR008278; 4-PPantetheinyl_Trfase.
DR   InterPro; IPR002582; ACPS.
DR   InterPro; IPR004568; PPantethiene-prot_Trfase.
DR   Pfam; PF01648; ACPS; 1.
DR   ProDom; PD004282; ACPS; 1.
DR   TIGRFAMs; TIGR00516; acpS; 1.
DR   TIGRFAMs; TIGR00556; pantethn_trn; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; Fatty acid biosynthesis;
KW   Lipid synthesis; Magnesium; Metal-binding; Transferase.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    130       Holo-[acyl-carrier-protein] synthase.
FT                                /FTId=PRO_1000008454.
FT   METAL         9      9       Magnesium (By similarity).
FT   METAL        58     58       Magnesium (By similarity).
SQ   SEQUENCE   130 AA;  14165 MW;  574FE43BAA348A94 CRC64;
     MAIVGVGIDL VSIPDFAEQV DRPGTVFAET FTPGERRDAA DKSSSAARHL AARWAAKEAV
     IKAWSSSRFS KRPALPEGIH RDIEVVTDMW GRPKVRLSGE IAKHLEDVTI HVSLTHEDQT
     AAAVAIIEEP
//