ID ACPS_MYCS2 Reviewed; 130 AA. AC A0R1H6; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 09-JAN-2007, sequence version 1. DT 22-JUL-2008, entry version 18. DE RecName: Full=Holo-[acyl-carrier-protein] synthase; DE Short=Holo-ACP synthase; DE EC=2.7.8.7; DE AltName: Full=4'-phosphopantetheinyl transferase acpS; GN Name=acpS; OrderedLocusNames=MSMEG_4756; OS Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155). OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium. OX NCBI_TaxID=246196; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., RA Fraser C.M.; RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Transfers the 4'-phosphopantetheine moiety from coenzyme CC A to a Ser of acyl-carrier-protein (By similarity). CC -!- CATALYTIC ACTIVITY: CoA-(4'-phosphopantetheine) + apo-[acyl- CC carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl- CC carrier-protein]. CC -!- COFACTOR: Magnesium (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the P-Pant transferase superfamily. AcpS CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000480; ABK75003.1; -; Genomic_DNA. DR RefSeq; YP_889014.1; -. DR GeneID; 4536674; -. DR GenomeReviews; CP000480_GR; MSMEG_4756. DR KEGG; msm:MSMEG_4756; -. DR NMPDR; fig|246196.1.peg.4746; -. DR TIGR; MSMEG_4756; -. DR GO; GO:0005737; C:cytoplasm; IEA:HAMAP. DR GO; GO:0008897; F:holo-[acyl-carrier-protein] synthase activity; IEA:HAMAP. DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:HAMAP. DR HAMAP; MF_00101; -; 1. DR InterPro; IPR008278; 4-PPT_transf. DR InterPro; IPR002582; ACPS. DR InterPro; IPR004568; Pantethn_Trfase. DR Pfam; PF01648; ACPS; 1. DR ProDom; PD004282; ACPS; 1. DR TIGRFAMs; TIGR00516; acpS; 1. DR TIGRFAMs; TIGR00556; pantethn_trn; 1. PE 3: Inferred from homology; KW Complete proteome; Cytoplasm; Fatty acid biosynthesis; KW Lipid synthesis; Magnesium; Metal-binding; Transferase. FT CHAIN 1 130 Holo-[acyl-carrier-protein] synthase. FT /FTId=PRO_1000008454. FT METAL 9 9 Magnesium (By similarity). FT METAL 58 58 Magnesium (By similarity). SQ SEQUENCE 130 AA; 14165 MW; 574FE43BAA348A94 CRC64; MAIVGVGIDL VSIPDFAEQV DRPGTVFAET FTPGERRDAA DKSSSAARHL AARWAAKEAV IKAWSSSRFS KRPALPEGIH RDIEVVTDMW GRPKVRLSGE IAKHLEDVTI HVSLTHEDQT AAAVAIIEEP //