ID A0QYW6_MYCS2 Unreviewed; 147 AA. AC A0QYW6; DT 09-JAN-2007, integrated into UniProtKB/TrEMBL. DT 09-JAN-2007, sequence version 1. DT 27-SEP-2017, entry version 83. DE SubName: Full=Universal stress protein family protein, putative {ECO:0000313|EMBL:ABK75086.1}; GN OrderedLocusNames=MSMEG_3811 {ECO:0000313|EMBL:ABK75086.1}; OS Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155). OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; OC Mycobacterium. OX NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK75086.1, ECO:0000313|Proteomes:UP000000757}; RN [1] {ECO:0000313|EMBL:ABK75086.1, ECO:0000313|Proteomes:UP000000757} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757}; RA Hayward D., Fahey B.; RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000213|PDB:5AHW} RP X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH CAMP. RX PubMed=25802331; DOI=10.1074/JBC.M115.644856; RA Banerjee A., Adolph R.S., Gopalakrishnapai J., Kleinboelting S., RA Emmerich C., Steegborn C., Visweswariah S.S.; RT "A universal stress protein (USP) in mycobacteria binds cAMP."; RL J. Biol. Chem. 290:12731-12743(2015). CC -!- SIMILARITY: Belongs to the universal stress protein A family. CC {ECO:0000256|SAAS:SAAS00569497}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000480; ABK75086.1; -; Genomic_DNA. DR RefSeq; WP_003895256.1; NZ_CP009494.1. DR RefSeq; YP_888104.1; NC_008596.1. DR PDB; 5AHW; X-ray; 2.15 A; A/B/C/D/E/F=1-147. DR PDBsum; 5AHW; -. DR SMR; A0QYW6; -. DR STRING; 246196.MSMEG_3811; -. DR EnsemblBacteria; ABK75086; ABK75086; MSMEG_3811. DR EnsemblBacteria; AFP40181; AFP40181; MSMEI_3722. DR GeneID; 4533772; -. DR KEGG; msb:LJ00_18930; -. DR KEGG; msm:MSMEG_3811; -. DR PATRIC; fig|246196.19.peg.3749; -. DR eggNOG; ENOG4108Z0U; Bacteria. DR eggNOG; COG0589; LUCA. DR HOGENOM; HOG000238897; -. DR OMA; VHYSIEF; -. DR OrthoDB; POG091H01X8; -. DR Proteomes; UP000000757; Chromosome. DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW. DR GO; GO:0006950; P:response to stress; IEA:InterPro. DR Gene3D; 3.40.50.620; -; 1. DR InterPro; IPR014729; Rossmann-like_a/b/a_fold. DR InterPro; IPR006015; Universal_stress_UspA. DR InterPro; IPR006016; UspA. DR Pfam; PF00582; Usp; 1. DR PRINTS; PR01438; UNVRSLSTRESS. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:5AHW}; cAMP {ECO:0000213|PDB:5AHW}; KW Complete proteome {ECO:0000313|Proteomes:UP000000757}; KW Nucleotide-binding {ECO:0000213|PDB:5AHW}; KW Reference proteome {ECO:0000313|Proteomes:UP000000757}. FT NP_BIND 10 16 cAMP. {ECO:0000213|PDB:5AHW}. FT NP_BIND 114 116 cAMP. {ECO:0000213|PDB:5AHW}. FT BINDING 40 40 cAMP; via amide nitrogen and carbonyl FT oxygen. {ECO:0000213|PDB:5AHW}. FT BINDING 95 95 cAMP. {ECO:0000213|PDB:5AHW}. FT BINDING 146 146 cAMP. {ECO:0000213|PDB:5AHW}. SQ SEQUENCE 147 AA; 15207 MW; 7C6DB4B5EDE5F879 CRC64; MSAYQTVVVG TDGSDSSLRA VDRAGQIAAA SNAKLIIATA YFPQSEDSRA ADVLKDEGYK MAGNAPIYAI LREANDRAKA AGATDIEERP VVGAPVDALV ELADEVKADL LVVGNVGLST IAGRLLGSVP ANVARRSKTD VLIVHTS //