ID A0QYW6_MYCS2 Unreviewed; 147 AA. AC A0QYW6; DT 09-JAN-2007, integrated into UniProtKB/TrEMBL. DT 09-JAN-2007, sequence version 1. DT 24-JUN-2015, entry version 64. DE SubName: Full=Mycobacterium smegmatis str. MC2 155, complete genome {ECO:0000313|EMBL:AIU08930.1}; DE SubName: Full=Universal stress protein family protein, putative {ECO:0000313|EMBL:ABK75086.1}; DE SubName: Full=UspA domain protein {ECO:0000313|EMBL:AFP40181.1}; GN OrderedLocusNames=MSMEG_3811 {ECO:0000313|EMBL:ABK75086.1}, MSMEI_3722 GN {ECO:0000313|EMBL:AFP40181.1}; GN ORFNames=LJ00_18930 {ECO:0000313|EMBL:AIU08930.1}; OS Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155). OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; OC Mycobacterium. OX NCBI_TaxID=246196 {ECO:0000313|EMBL:ABK75086.1, ECO:0000313|Proteomes:UP000000757}; RN [1] {ECO:0000313|EMBL:AFP40181.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MC2 155 {ECO:0000313|EMBL:AFP40181.1}; RX PubMed=16381882; DOI=10.1093/nar/gkj060; RA Perrodou E., Deshayes C., Muller J., Schaeffer C., Van Dorsselaer A., RA Ripp R., Poch O., Reyrat J.M., Lecompte O.; RT "ICDS database: interrupted CoDing sequences in prokaryotic genomes."; RL Nucleic Acids Res. 34:D338-D343(2006). RN [2] {ECO:0000313|EMBL:ABK75086.1, ECO:0000313|Proteomes:UP000000757} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000000757}, and RC MC2 155 {ECO:0000313|EMBL:ABK75086.1}; RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., RA Fraser C.M.; RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AFP40181.1, ECO:0000313|Proteomes:UP000006158} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000006158}, and RC MC2 155 {ECO:0000313|EMBL:AFP40181.1}; RX PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20; RA Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C., RA Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.; RT "Interrupted coding sequences in Mycobacterium smegmatis: authentic RT mutations or sequencing errors?"; RL Genome Biol. 8:R20.1-R20.9(2007). RN [4] {ECO:0000313|EMBL:AFP40181.1, ECO:0000313|Proteomes:UP000006158} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700084 / mc(2)155, and MC2 155; RX PubMed=18955433; DOI=10.1101/gr.081901.108; RA Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M., RA Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.; RT "Ortho-proteogenomics: multiple proteomes investigation through RT orthology and a new MS-based protocol."; RL Genome Res. 19:128-135(2009). RN [5] {ECO:0000313|EMBL:AIU08930.1, ECO:0000313|Proteomes:UP000029906} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700084 / mc(2)155 {ECO:0000313|Proteomes:UP000029906}, and RC MC2 155 {ECO:0000313|EMBL:AIU08930.1}; RX PubMed=25657281; DOI=10.1128/genomeA.01520-14; RA Mohan A., Padiadpu J., Baloni P., Chandra N.; RT "Complete genome sequences of a Mycobacterium smegmatis laboratory RT strain (MC2 155) and isoniazid-resistant (4XR1/R2) mutant strains."; RL Genome Announc. 3:E01520-E01520(2015). RN [6] {ECO:0000213|PDB:5AHW} RP X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH CAMP. RX PubMed=25802331; DOI=10.1074/JBC.M115.644856; RA Banerjee A., Adolph R.S., Gopalakrishnapai J., Kleinboelting S., RA Emmerich C., Steegborn C., Visweswariah S.S.; RT "A Universal Stress Protein (USP) in Mycobacteria binds cAMP."; RL J. Biol. Chem. 0:0-0(2015). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000480; ABK75086.1; -; Genomic_DNA. DR EMBL; CP001663; AFP40181.1; -; Genomic_DNA. DR EMBL; CP009494; AIU08930.1; -; Genomic_DNA. DR RefSeq; WP_003895256.1; NC_018289.1. DR RefSeq; YP_006568476.1; NC_018289.1. DR RefSeq; YP_888104.1; NC_008596.1. DR PDB; 5AHW; X-ray; 2.15 A; A/B/C/D/E/F=1-147. DR PDBsum; 5AHW; -. DR STRING; 246196.MSMEG_3811; -. DR EnsemblBacteria; ABK75086; ABK75086; MSMEG_3811. DR EnsemblBacteria; AFP40181; AFP40181; MSMEI_3722. DR EnsemblBacteria; AIU08930; AIU08930; LJ00_18930. DR GeneID; 4533772; -. DR KEGG; msm:MSMEG_3811; -. DR PATRIC; 18080013; VBIMycSme59918_3749. DR eggNOG; COG0589; -. DR HOGENOM; HOG000238897; -. DR OMA; IACAYYP; -. DR OrthoDB; EOG65BDRM; -. DR BioCyc; MSME246196:GJ4Y-3810-MONOMER; -. DR Proteomes; UP000000757; Chromosome. DR Proteomes; UP000006158; Chromosome. DR Proteomes; UP000029906; Chromosome. DR GO; GO:0006950; P:response to stress; IEA:InterPro. DR Gene3D; 3.40.50.620; -; 1. DR InterPro; IPR014729; Rossmann-like_a/b/a_fold. DR InterPro; IPR006015; Universal_stress_UspA. DR InterPro; IPR006016; UspA. DR Pfam; PF00582; Usp; 1. DR PRINTS; PR01438; UNVRSLSTRESS. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:5AHW}; cAMP {ECO:0000213|PDB:5AHW}; KW Complete proteome {ECO:0000313|Proteomes:UP000000757, KW ECO:0000313|Proteomes:UP000006158}; KW Nucleotide-binding {ECO:0000213|PDB:5AHW}; KW Reference proteome {ECO:0000313|Proteomes:UP000000757}. FT NP_BIND 10 16 cAMP. {ECO:0000213|PDB:5AHW}. FT NP_BIND 114 116 cAMP. {ECO:0000213|PDB:5AHW}. FT BINDING 40 40 cAMP; via amide nitrogen and carbonyl FT oxygen. {ECO:0000213|PDB:5AHW}. FT BINDING 146 146 cAMP. {ECO:0000213|PDB:5AHW}. SQ SEQUENCE 147 AA; 15207 MW; 7C6DB4B5EDE5F879 CRC64; MSAYQTVVVG TDGSDSSLRA VDRAGQIAAA SNAKLIIATA YFPQSEDSRA ADVLKDEGYK MAGNAPIYAI LREANDRAKA AGATDIEERP VVGAPVDALV ELADEVKADL LVVGNVGLST IAGRLLGSVP ANVARRSKTD VLIVHTS //