ID   PLS5_HUMAN              Reviewed;         271 AA.
AC   A0PG75; B2RXK5;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 2.
DT   09-APR-2025, entry version 115.
DE   RecName: Full=Phospholipid scramblase family member 5;
GN   Name=PLSCR5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Li X., Xie Y., Mao Y.;
RT   "Cloning and characterization of a novel putative scramblase.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A0PG75-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A0PG75-2; Sequence=VSP_054160;
CC   -!- DOMAIN: The N-terminal proline-rich domain (PRD) is required for
CC       phospholipid scramblase activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phospholipid scramblase family.
CC       {ECO:0000305}.
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DR   EMBL; AY436642; AAR99737.1; -; mRNA.
DR   EMBL; AC116544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC157886; AAI57887.1; -; mRNA.
DR   EMBL; BC171917; AAI71917.1; -; mRNA.
DR   CCDS; CCDS46931.1; -. [A0PG75-1]
DR   CCDS; CCDS82853.1; -. [A0PG75-2]
DR   RefSeq; NP_001078889.1; NM_001085420.2. [A0PG75-1]
DR   RefSeq; NP_001308174.1; NM_001321245.2. [A0PG75-2]
DR   AlphaFoldDB; A0PG75; -.
DR   BioGRID; 133006; 61.
DR   IntAct; A0PG75; 2.
DR   STRING; 9606.ENSP00000390111; -.
DR   PhosphoSitePlus; A0PG75; -.
DR   BioMuta; PLSCR5; -.
DR   PaxDb; 9606-ENSP00000390111; -.
DR   Antibodypedia; 62410; 32 antibodies from 12 providers.
DR   DNASU; 389158; -.
DR   Ensembl; ENST00000443512.2; ENSP00000390111.1; ENSG00000231213.7. [A0PG75-1]
DR   Ensembl; ENST00000482567.5; ENSP00000418626.1; ENSG00000231213.7. [A0PG75-2]
DR   Ensembl; ENST00000492200.5; ENSP00000417184.1; ENSG00000231213.7. [A0PG75-1]
DR   GeneID; 389158; -.
DR   KEGG; hsa:389158; -.
DR   MANE-Select; ENST00000443512.2; ENSP00000390111.1; NM_001085420.2; NP_001078889.1.
DR   UCSC; uc010hvb.4; human. [A0PG75-1]
DR   AGR; HGNC:19952; -.
DR   CTD; 389158; -.
DR   GeneCards; PLSCR5; -.
DR   HGNC; HGNC:19952; PLSCR5.
DR   HPA; ENSG00000231213; Not detected.
DR   neXtProt; NX_A0PG75; -.
DR   OpenTargets; ENSG00000231213; -.
DR   PharmGKB; PA134902268; -.
DR   VEuPathDB; HostDB:ENSG00000231213; -.
DR   eggNOG; KOG0621; Eukaryota.
DR   GeneTree; ENSGT00940000161728; -.
DR   HOGENOM; CLU_053024_2_0_1; -.
DR   InParanoid; A0PG75; -.
DR   OMA; LWKQTSH; -.
DR   OrthoDB; 444338at2759; -.
DR   PhylomeDB; A0PG75; -.
DR   TreeFam; TF314939; -.
DR   PathwayCommons; A0PG75; -.
DR   BioGRID-ORCS; 389158; 6 hits in 1141 CRISPR screens.
DR   GeneWiki; PLSCR5; -.
DR   GenomeRNAi; 389158; -.
DR   Pharos; A0PG75; Tdark.
DR   PRO; PR:A0PG75; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; A0PG75; protein.
DR   Bgee; ENSG00000231213; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 18 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0017128; F:phospholipid scramblase activity; IBA:GO_Central.
DR   GO; GO:0017121; P:plasma membrane phospholipid scrambling; IBA:GO_Central.
DR   InterPro; IPR005552; Scramblase.
DR   InterPro; IPR025659; Tubby-like_C.
DR   PANTHER; PTHR23248:SF25; PHOSPHOLIPID SCRAMBLASE FAMILY MEMBER 5; 1.
DR   PANTHER; PTHR23248; PHOSPHOLIPID SCRAMBLASE-RELATED; 1.
DR   Pfam; PF03803; Scramblase; 1.
DR   SUPFAM; SSF54518; Tubby C-terminal domain-like; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..271
FT                   /note="Phospholipid scramblase family member 5"
FT                   /id="PRO_0000293720"
FT   REGION          1..45
FT                   /note="Proline-rich domain (PRD)"
FT                   /evidence="ECO:0000250"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..10
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         52..63
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_054160"
FT   VARIANT         110
FT                   /note="R -> S (in dbSNP:rs12107687)"
FT                   /id="VAR_057700"
FT   CONFLICT        82
FT                   /note="T -> A (in Ref. 1; AAR99737)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   271 AA;  30027 MW;  69CBE4A4E2A6DB54 CRC64;
     MASKDAQNQR RGLPGFLPGA PDPDQSLPAS SNPGNQAWQL SLPLPSSFLP TVSLPPGLEY
     LSQLDLIIIH QQVELLGMIL GTETSNKYEI KNSLGQRIYF AVEESICFNR TFCSTLRSCT
     LRITDNSGRE VITVNRPLRC NSCWCPCYLQ ELEIQAPPGT IVGYVTQKWD PFLPKFTIQN
     ANKEDILKIV GPCVTCGCFG DVDFEVKTIN EKLTIGKISK YWSGFVNDVF TNADNFGIHV
     PADLDVTVKA AMIGACFLFD FMFFEHSLAG L
//