ID A0KGJ2_AERHH Unreviewed; 530 AA. AC A0KGJ2; DT 12-DEC-2006, integrated into UniProtKB/TrEMBL. DT 12-DEC-2006, sequence version 1. DT 04-DEC-2007, entry version 11. DE Bifunctional purine biosynthesis protein PurH (EC 2.1.2.3) DE (EC 3.5.4.10). GN Name=purH; OrderedLocusNames=AHA_0841; OS Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240). OC Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales; OC Aeromonadaceae; Aeromonas. OX NCBI_TaxID=380703; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16980456; DOI=10.1128/JB.00621-06; RA Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., RA Haft D.H., Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., RA Jin S., Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.; RT "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all RT trades."; RL J. Bacteriol. 188:8272-8282(2006). CC -!- CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + 5-amino-1-(5- CC phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- CC formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. CC -!- CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D- CC ribosyl)imidazole-4-carboxamide. CC -!- PATHWAY: Context: Purine biosynthesis. CC -!- PATHWAY: Nucleotide biosynthesis; IMP biosynthesis; 5-formamido-1- CC (5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5- CC phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): CC step 1/1. CC -!- PATHWAY: Nucleotide biosynthesis; IMP biosynthesis; IMP from 5- CC formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step CC 1/1. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000462; ABK36339.1; -; Genomic_DNA. DR RefSeq; YP_855383.1; -. DR GeneID; 4487128; -. DR KEGG; aha:AHA_0841; -. DR TIGR; AHA_0841; -. DR GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:InterPro. DR GO; GO:0004643; F:phosphoribosylaminoimidazolecarboxamide for...; IEA:InterPro. DR GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:InterPro. DR InterPro; IPR002695; AICARFT_IMPCHas. DR InterPro; IPR013982; AICARFT_IMPCHas_formly. DR InterPro; IPR011607; MGS. DR PANTHER; PTHR11692; AICARFT_IMPCHas; 1. DR Pfam; PF01808; AICARFT_IMPCHas; 1. DR Pfam; PF02142; MGS; 1. DR ProDom; PD004666; AICARFT_IMPCHas; 1. DR SMART; SM00798; AICARFT_IMPCHas; 1. DR TIGRFAMs; TIGR00355; purH; 1. PE 4: Predicted; KW Complete proteome; Hydrolase; Multifunctional enzyme; KW Purine biosynthesis; Transferase. SQ SEQUENCE 530 AA; 56898 MW; 9EA6E3286CCD0888 CRC64; MEQARPIRRA LLSVSDKTGI LEFAKALNER GVALLSTGGT AKLLADAGLP VTEVSDYTGF PEMMDGRVKT LHPKVHGGIL GRREQDDAIM AQHAISPIDM VVVNLYPFAA TVAKPGCTLA DAVENIDIGG PTMVRSAAKN HKDVAIVVKA ADYDRVIREM DGNGNSLKLA TRFDLAIAAF EHTAAYDGMI ANYFGTMVPS YGDNKEGDEE SRFPRTFNSQ FIKKQDMRYG ENSHQAAAFY AEEQAAPGSV ASAIQLQGKA LSYNNIADTD AALECVKEFD QPACVIVKHA NPCGVAIGSD LLSAYERAWQ TDPTSAFGGI IAFNRELDGA TAKAIVERQF VEVIIAPTVS QAARDAVAAK QNVRLLECGQ WTAPAQGFDF KRVNGGLLVQ ERDLGMVTLG DLTVVSKRQP TEAELNDLLF CWKVAKFVKS NAIVYAKDGQ TIGVGAGQMS RVYSAKIAGI KAEDEGLTVA GSVMASDAFF PFRDGIDAAA AAGISCVIQP GGSMRDQEVI DAADEHGMCM LFTNMRHFRH //