ID UPPP1_BURCH Reviewed; 276 AA. AC A0K593; DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot. DT 12-DEC-2006, sequence version 1. DT 10-JUN-2008, entry version 18. DE Undecaprenyl-diphosphatase 1 (EC 3.6.1.27) (Undecaprenyl pyrophosphate DE phosphatase 1) (Bacitracin resistance protein 1). GN Name=uppP1; OrderedLocusNames=Bcen2424_0917; OS Burkholderia cenocepacia (strain HI2424). OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex. OX NCBI_TaxID=331272; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., RA Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., RA Hauser L., Kyrpides N., Kim E., LiPuma J.J., Gonzalez C.F., RA Konstantinidis K., Tiedje J.M., Richardson P.; RT "Complete sequence of chromosome 1 of Burkholderia cenocepacia RT HI2424."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the dephosphorylation of undecaprenyl CC diphosphate (UPP). Confers resistance to bacitracin (By CC similarity). CC -!- CATALYTIC ACTIVITY: Undecaprenyl diphosphate + H(2)O = CC undecaprenyl phosphate + phosphate. CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane CC protein (By similarity). CC -!- MISCELLANEOUS: Bacitracin is thought to be involved in the CC inhibition of peptidoglycan synthesis by sequestering undecaprenyl CC diphosphate, thereby reducing the pool of lipid carrier available. CC -!- SIMILARITY: Belongs to the uppP family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000458; ABK07670.1; -; Genomic_DNA. DR RefSeq; YP_834563.1; -. DR GeneID; 4450864; -. DR GenomeReviews; CP000458_GR; Bcen2424_0917. DR KEGG; bch:Bcen2424_0917; -. DR HOGENOM; A0K593; -. DR GO; GO:0005886; C:plasma membrane; IEA:HAMAP. DR GO; GO:0050380; F:undecaprenyl-diphosphatase activity; IEA:HAMAP. DR HAMAP; MF_01006; -; 1. DR InterPro; IPR003824; Bacitracin-R_BacA. DR Pfam; PF02673; BacA; 1. DR TIGRFAMs; TIGR00753; undec_PP_bacA; 1. PE 3: Inferred from homology; KW Antibiotic resistance; Cell shape; Cell wall biogenesis/degradation; KW Complete proteome; Hydrolase; Inner membrane; Membrane; KW Peptidoglycan synthesis; Transmembrane. FT CHAIN 1 276 Undecaprenyl-diphosphatase 1. FT /FTId=PRO_0000290691. FT TRANSMEM 83 103 Potential. FT TRANSMEM 108 128 Potential. FT TRANSMEM 187 207 Potential. FT TRANSMEM 217 237 Potential. FT TRANSMEM 252 272 Potential. SQ SEQUENCE 276 AA; 30227 MW; 2E18CE6F2C99B5EF CRC64; MDWILICKAL ILGVVEGLTE FLPVSSTGHL IVAGSFLNFN DSHAKTFDVV IQFGAILAVC WEYRQRIVSV VSGLPSRPDA QRFTLNVVIA TIPAIALGLL FEKKIKAVLF SPVPVAFALV VGGAIILWAE ARQRERSEPP RVMSVDALTP LDALKVGIAQ CFALVPGMSR SGSTIIGGML FGLDRRVATE FSFFLAIPII FGATLYETVK DWQAFTVDSL GLFALGLVAA FVSAFVCVRW LLRYVATHDF TVFAWYRIAF GLFVLLVGYS GWLNWA //