ID A0JPK0_RAT Unreviewed; 338 AA. AC A0JPK0; DT 12-DEC-2006, integrated into UniProtKB/TrEMBL. DT 12-DEC-2006, sequence version 1. DT 29-MAY-2024, entry version 98. DE RecName: Full=Cyclin-A2 {ECO:0000256|ARBA:ARBA00019673}; GN Name=Ccna2 {ECO:0000313|EMBL:AAI27463.1, ECO:0000313|RGD:621059}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAI27463.1}; RN [1] {ECO:0000313|EMBL:AAI27463.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Liver {ECO:0000313|EMBL:AAI27463.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the cyclin family. CC {ECO:0000256|RuleBase:RU000383}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC127462; AAI27463.1; -; mRNA. DR AlphaFoldDB; A0JPK0; -. DR AGR; RGD:621059; -. DR RGD; 621059; Ccna2. DR PhylomeDB; A0JPK0; -. DR GO; GO:0005813; C:centrosome; IBA:GO_Central. DR GO; GO:0097122; C:cyclin A2-CDK1 complex; ISO:RGD. DR GO; GO:0097124; C:cyclin A2-CDK2 complex; ISO:RGD. DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; ISO:RGD. DR GO; GO:0005737; C:cytoplasm; ISO:RGD. DR GO; GO:0001939; C:female pronucleus; ISO:RGD. DR GO; GO:0001940; C:male pronucleus; ISO:RGD. DR GO; GO:0005634; C:nucleus; ISO:RGD. DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; ISO:RGD. DR GO; GO:0019904; F:protein domain specific binding; ISO:RGD. DR GO; GO:0019901; F:protein kinase binding; ISO:RGD. DR GO; GO:0031100; P:animal organ regeneration; IEP:RGD. DR GO; GO:0044843; P:cell cycle G1/S phase transition; ISO:RGD. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0071314; P:cellular response to cocaine; IEP:RGD. DR GO; GO:0071392; P:cellular response to estradiol stimulus; IEP:RGD. DR GO; GO:0071456; P:cellular response to hypoxia; IEP:RGD. DR GO; GO:1990314; P:cellular response to insulin-like growth factor stimulus; IEP:RGD. DR GO; GO:0044320; P:cellular response to leptin stimulus; IEP:RGD. DR GO; GO:0071373; P:cellular response to luteinizing hormone stimulus; IEP:RGD. DR GO; GO:0071732; P:cellular response to nitric oxide; IEP:RGD. DR GO; GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD. DR GO; GO:0036120; P:cellular response to platelet-derived growth factor stimulus; IEP:RGD. DR GO; GO:0090102; P:cochlea development; IEP:RGD. DR GO; GO:0006351; P:DNA-templated transcription; ISO:RGD. DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; ISO:RGD. DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central. DR GO; GO:2000573; P:positive regulation of DNA biosynthetic process; IMP:RGD. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISO:RGD. DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IMP:RGD. DR GO; GO:0043687; P:post-translational protein modification; ISO:RGD. DR GO; GO:0007265; P:Ras protein signal transduction; ISO:RGD. DR GO; GO:0006275; P:regulation of DNA replication; ISO:RGD. DR GO; GO:0032355; P:response to estradiol; IEP:RGD. DR GO; GO:0033762; P:response to glucagon; IEP:RGD. DR CDD; cd20561; CYCLIN_CCNA2_rpt1; 1. DR CDD; cd20564; CYCLIN_CCNA2_rpt2; 1. DR Gene3D; 1.10.472.10; Cyclin-like; 2. DR InterPro; IPR039361; Cyclin. DR InterPro; IPR013763; Cyclin-like_dom. DR InterPro; IPR036915; Cyclin-like_sf. DR InterPro; IPR004367; Cyclin_C-dom. DR InterPro; IPR006671; Cyclin_N. DR InterPro; IPR048258; Cyclins_cyclin-box. DR PANTHER; PTHR10177:SF444; CYCLIN-A2; 1. DR PANTHER; PTHR10177; CYCLINS; 1. DR Pfam; PF02984; Cyclin_C; 1. DR Pfam; PF00134; Cyclin_N; 1. DR SMART; SM00385; CYCLIN; 2. DR SMART; SM01332; Cyclin_C; 1. DR SUPFAM; SSF47954; Cyclin-like; 2. DR PROSITE; PS00292; CYCLINS; 1. PE 2: Evidence at transcript level; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306}; KW Cell division {ECO:0000256|ARBA:ARBA00022618}; KW Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383}; KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT DOMAIN 122..206 FT /note="Cyclin-like" FT /evidence="ECO:0000259|SMART:SM00385" FT DOMAIN 215..333 FT /note="Cyclin C-terminal" FT /evidence="ECO:0000259|SMART:SM01332" FT DOMAIN 219..302 FT /note="Cyclin-like" FT /evidence="ECO:0000259|SMART:SM00385" SQ SEQUENCE 338 AA; 38992 MW; 3316E24248577310 CRC64; MPWLLVPLSL YPEPENHWYL LIIQWMVVLI AGQTHGRQNS CYRQLCRCYD LTVETRDVES PHAMDISIVL EDEKPVNVNE VPDYHEDIHT YLREMEVKCK PKVSYMKRQP DITNSMRAIL VDWLVEVGEE YKLQNETLHL AVNYIDRFLS SMSVLRGKLQ LVGTAAMLLA SKFEEIYPPE VAEFVYITDD TYSKKQVLRM EHLVLKVLAF DLAAPTVNQF LTQYFLHLQP ANCKVESLAM FLGELSLIDA DPYLKYLPSL IAGAAFHLAL YTVTGQSWPE SLVQKTGYTL ESLKPCLMDL HQTYLKAPQH AQQSIREKYK HSKYHSVSLL NPPETLNV //