ID A0JMC9_DANRE Unreviewed; 947 AA. AC A0JMC9; DT 12-DEC-2006, integrated into UniProtKB/TrEMBL. DT 12-DEC-2006, sequence version 1. DT 22-FEB-2023, entry version 78. DE SubName: Full=ADNP homeobox 2b {ECO:0000313|RefSeq:NP_001073482.1}; DE SubName: Full=Si:ch211-129n15.3 {ECO:0000313|EMBL:AAI25829.1}; GN Name=si:ch211-129n15.3 {ECO:0000313|EMBL:AAI25829.1, GN ECO:0000313|RefSeq:NP_001073482.1}; GN Synonyms=wu:fc49c08 {ECO:0000313|RefSeq:NP_001073482.1}, wu:fi26a03 GN {ECO:0000313|RefSeq:NP_001073482.1}, zgc:152871 GN {ECO:0000313|RefSeq:NP_001073482.1}; GN OrderedLocusNames=adnp2b {ECO:0000313|RefSeq:NP_001073482.1, GN ECO:0000313|ZFIN:ZDB-GENE-030131-5930}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI25829.1}; RN [1] {ECO:0000313|RefSeq:NP_001073482.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB {ECO:0000313|RefSeq:NP_001073482.1}; RX PubMed=15520368; DOI=10.1073/pnas.0407241101; RA Song H.D., Sun X.J., Deng M., Zhang G.W., Zhou Y., Wu X.Y., Sheng Y., RA Chen Y., Ruan Z., Jiang C.L., Fan H.Y., Zon L.I., Kanki J.P., Liu T.X., RA Look A.T., Chen Z.; RT "Hematopoietic gene expression profile in zebrafish kidney marrow."; RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004). RN [2] {ECO:0000313|EMBL:AAI25829.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=AB {ECO:0000313|EMBL:AAI25829.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:AAI25829.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|RefSeq:NP_001073482.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB {ECO:0000313|RefSeq:NP_001073482.1}; RX PubMed=23071114; RA Dresner E., Malishkevich A., Arviv C., Leibman Barak S., Alon S., Ofir R., RA Gothilf Y., Gozes I.; RT "Novel evolutionary-conserved role for the activity-dependent RT neuroprotective protein (ADNP) family that is important for RT erythropoiesis."; RL J. Biol. Chem. 287:40173-40185(2012). RN [4] {ECO:0000313|RefSeq:NP_001073482.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB {ECO:0000313|RefSeq:NP_001073482.1}; RX PubMed=26469318; RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M., RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D., RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E., RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M., RA Reith W., Hertzano R.; RT "RFX transcription factors are essential for hearing in mice."; RL Nat. Commun. 6:8549-8549(2015). RN [5] {ECO:0000313|RefSeq:NP_001073482.1} RP IDENTIFICATION. RC STRAIN=AB {ECO:0000313|RefSeq:NP_001073482.1}; RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC125828; AAI25829.1; -; mRNA. DR RefSeq; NP_001073482.1; NM_001080013.1. DR GeneID; 564171; -. DR KEGG; dre:564171; -. DR CTD; 564171; -. DR ZFIN; ZDB-GENE-030131-5930; adnp2b. DR OrthoDB; 5301636at2759; -. DR PhylomeDB; A0JMC9; -. DR Proteomes; UP000000437; Chromosome 19. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0043249; P:erythrocyte maturation; IMP:ZFIN. DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central. DR InterPro; IPR038861; ADNP/ADNP2. DR InterPro; IPR045762; ADNP_Znf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR15740:SF2; ACTIVITY-DEPENDENT NEUROPROTECTOR HOMEOBOX PROTEIN 2; 1. DR PANTHER; PTHR15740; NEUROPROTECTIVE PEPTIDE-CONTAINING PROTEIN; 1. DR Pfam; PF19627; ADNP_N; 2. DR SMART; SM00355; ZnF_C2H2; 6. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, KW ECO:0000313|RefSeq:NP_001073482.1}; KW Homeobox {ECO:0000313|RefSeq:NP_001073482.1}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A0JMC9}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}. FT DOMAIN 552..573 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS00028" FT REGION 385..408 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 443..475 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 747..783 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 787..818 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 759..782 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 947 AA; 106005 MW; 8201D45FB313520C CRC64; MYQFPVKGLE KIRRTRRKVK NILGEFGLEA CLNLGQELQE YYPGDNIFDA TDWCNLSDGF DGRWRKKWGY RTQGLCCTLC NFSTRSWHTY KTHVQRYHDE EEHMCKLAAC ASCPFIAHPR LVCKHLKLFH NEDTKSETSA APQLPPRAVN GTTFQCRRCH IQDTLLYSVK KHVLLYHYTS TLNKYAGQRT EQELVALGDR SQKFYCKKCY ISAESSEHLL YHLLTSDKHK ELDVHIRSLI FETDNKKQFP ALAPKAQGPS PVMMMKDQPA ATATLAAGGI TGVENGGSAV IATPGTSQAF LPTQASALVQ LASAEAKGLL RPGVPMGFQN TQMPRPALPP PPNSIPPNQM PVRVGLPNQA QLQPVSRQIV LPPGVRLNVP GVRPPTPQSF SANPRLPLNQ PPSGGTMLTS QSLLSHLIPT GNKVDGLPTY TLAPLQVLSV QANNSQGVSK PQLPPSQNNP AAQQNKQSSG LSTPKQTKKW ITCPICNELF PSDIYESHPE VHKEAAKLPK VGLAARAPFL KKMPDKTVKC LTCKILISEK GVFEHLLHGM NCLFCSGLFY SIKQLVDHIQ IEHNVSRKSN CDFMRREYRL YTDDSGYLLF PYFDIRTTAP KLIMGEKELN LALVTSSLDL IFVKMLPNNP QGVNQQYTPC KMPTPKPDST ECPFCSEKLL NKECYHMHLK EKHFIVPTLH AILKTPSYRC LYCGGVYTGK TTTKAIIVHL AKCRSAPKSV RESDKLTLGL AVTPKANRAH GSYPAHPRQI TGPTPTSAQA SVPSTQPPES EAEMQSKMRL EIAFREAMEA NRKEREERLA RKRKLERDRL AGLTLPSPDI VVDPSVKLAL DPAGMELRTF EDRREFVNKY FNTQPYPLKK EIIALSARLL LNKTDVACQI SSKRTRCMKN IQKMKAVVLL GFNMTEVMKL KHDLLIPEIE PEKVATMADT DMEVDQE //