ID A0FFQ6_9INFA Unreviewed; 556 AA. AC A0FFQ6; DT 28-NOV-2006, integrated into UniProtKB/TrEMBL. DT 28-NOV-2006, sequence version 1. DT 03-MAY-2011, entry version 36. DE SubName: Full=Hemagglutinin; DE Flags: Fragment; GN Name=HA; OS Influenza A virus (A/goose/Guiyang/337/2006(H5N1)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=407713; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/goose/Guiyang/337/2006; RX PubMed=17075062; DOI=10.1073/pnas.0608157103; RA Smith G.J., Fan X.H., Wang J., Li K.S., Qin K., Zhang J.X., RA Vijaykrishna D., Cheung C.L., Huang K., Rayner J.M., Peiris J.S., RA Chen H., Webster R.G., Guan Y.; RT "Emergence and predominance of an H5N1 influenza variant in China."; RL Proc. Natl. Acad. Sci. U.S.A. 103:16936-16941(2006). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/goose/Guiyang/337/2006; RA Smith G.J.D., Guan Y.; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds to sialic acid-containing receptors on the cell CC surface, bringing about the attachment of the virus particle to CC the cell. Plays a major role in the determination of host range CC restriction and virulence. Class I viral fusion protein. CC Responsible for penetration of the virus into the cell cytoplasm CC by mediating the fusion of the membrane of the endocytosed virus CC particle with the endosomal membrane. Low pH in endosomes induce CC an irreversible conformational change in HA2, releasing the fusion CC hydrophobic peptide. Several trimers are required to form a CC competent fusion pore (By similarity). CC -!- FUNCTION: Binds to sialic acid-containing receptors on the cell CC surface, bringing about the attachment of the virus particle to CC the cell. This attachment induces virion internalization of about CC two third of the virus particles through clathrin-dependent CC endocytosis and about one third through a clathrin- and caveolin- CC independent pathway. Plays a major role in the determination of CC host range restriction and virulence. Class I viral fusion CC protein. Responsible for penetration of the virus into the cell CC cytoplasm by mediating the fusion of the membrane of the CC endocytosed virus particle with the endosomal membrane. Low pH in CC endosomes induces an irreversible conformational change in HA2, CC releasing the fusion hydrophobic peptide. Several trimers are CC required to form a competent fusion pore (By similarity). CC -!- SUBUNIT: Homotrimer of disulfide-linked HA1-HA2 (By similarity). CC -!- SIMILARITY: Belongs to the influenza viruses hemagglutinin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ992765; ABJ96698.1; -; Viral_cRNA. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:InterPro. DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro. DR GO; GO:0019064; P:viral envelope fusion with host membrane; IEA:InterPro. DR InterPro; IPR008980; Capsid_hemagglutn. DR InterPro; IPR013828; Hemagglutn_HA1_a/b_dom. DR InterPro; IPR013827; Hemagglutn_HA1_b-rbn_dom. DR InterPro; IPR000149; Hemagglutn_influenz_A. DR InterPro; IPR001364; Hemagglutn_influenz_A/B. DR InterPro; IPR013829; Hemagglutn_stalk. DR Gene3D; G3DSA:3.90.209.20; Haemagglutn_HA1_a/b; 1. DR Gene3D; G3DSA:2.10.77.10; Haemagglutn_HA1_b-ribbon; 1. DR Gene3D; G3DSA:3.90.20.10; Haemagglutn_stalk; 1. DR Pfam; PF00509; Hemagglutinin; 1. DR PRINTS; PR00330; HEMAGGLUTN1. DR PRINTS; PR00329; HEMAGGLUTN12. DR SUPFAM; SSF49818; Capsid_hemag; 1. PE 3: Inferred from homology; KW Clathrin- and caveolin-independent endocytosis of virus by host; KW Hemagglutinin; Host cell membrane; Host membrane; KW Host-virus interaction; Membrane; Transmembrane; Transmembrane helix; KW Viral envelope protein; Virion; Virus endocytosis by host. FT NON_TER 556 556 SQ SEQUENCE 556 AA; 62980 MW; 0974A8F404E126E4 CRC64; MEKIVLLLAI ISLVKSDQIC IGYHANNSTV QVDTIMEKNV TVTHAQDILE KTHNGKLCSL DGVKPLILRD CSVAGWLLGN PMCDEFINVP EWSYIVEKAS PANDLCYPGD FNDYEELKHL LSRINHFEKI QIIPKSSWPN HEASLGVSSA CPYLGESSFF RNVVWLIKKN SSYPTIKRSY NNTNQEDLLV LWGIHHPNDA AEQIKLYQNP NTYISVGTST LNQRLVPTIA TRSKVNGQSG RMEFFWTILK PNDAINFESN GNFIAPEYAY KIVKKGDSAI MKSELEYGNC NTKCQTPMGA INSSMPFHNI HPLTIGECPK YVKSNRLVLA TGLRNTLQRE RRRKKRGLFG AIAGFIEGGW QGMVDGWYGY HHSNEQGSGY AADKESTQKA IDGITNKVNS IINKMNTQFE AVGREFSNLE RRIENLNKKM EDGFLDVWTY NAELLVLMEN ERTLDFHDSN VKNLYDKVRL QLRDNAKELG NGCFEFYHKC DDECMESVKN GTYDYPQYSE EARLNREEIN GVKLESMGTY QILSIYSTVA SSLALAIMVA GLSLWM //