ID   A0AAP0B0B5_9ASPA        Unreviewed;       449 AA.
AC   A0AAP0B0B5;
DT   02-OCT-2024, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2024, sequence version 1.
DT   27-NOV-2024, entry version 2.
DE   RecName: Full=Vacuolar cation/proton exchanger {ECO:0000256|RuleBase:RU365028};
GN   Name=CAX1a {ECO:0000313|EMBL:KAK8921702.1};
GN   ORFNames=KSP39_PZI020250 {ECO:0000313|EMBL:KAK8921702.1};
OS   Platanthera zijinensis.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Orchidaceae;
OC   Orchidoideae; Orchideae; Orchidinae; Platanthera.
OX   NCBI_TaxID=2320716 {ECO:0000313|EMBL:KAK8921702.1, ECO:0000313|Proteomes:UP001418222};
RN   [1] {ECO:0000313|EMBL:KAK8921702.1, ECO:0000313|Proteomes:UP001418222}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lor287 {ECO:0000313|EMBL:KAK8921702.1};
RX   PubMed=35449401;
RA   Li M.H., Liu K.W., Li Z., Lu H.C., Ye Q.L., Zhang D., Wang J.Y., Li Y.F.,
RA   Zhong Z.M., Liu X., Yu X., Liu D.K., Tu X.D., Liu B., Hao Y., Liao X.Y.,
RA   Jiang Y.T., Sun W.H., Chen J., Chen Y.Q., Ai Y., Zhai J.W., Wu S.S.,
RA   Zhou Z., Hsiao Y.Y., Wu W.L., Chen Y.Y., Lin Y.F., Hsu J.L., Li C.Y.,
RA   Wang Z.W., Zhao X., Zhong W.Y., Ma X.K., Ma L., Huang J., Chen G.Z.,
RA   Huang M.Z., Huang L., Peng D.H., Luo Y.B., Zou S.Q., Chen S.P., Lan S.,
RA   Tsai W.C., Van de Peer Y., Liu Z.J.;
RT   "Genomes of leafy and leafless Platanthera orchids illuminate the evolution
RT   of mycoheterotrophy.";
RL   Nat. Plants 8:373-388(2022).
CC   -!- FUNCTION: Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+)
CC       and other metal ions into vacuoles using the proton gradient formed by
CC       H(+)-ATPase and H(+)-pyrophosphatase. {ECO:0000256|ARBA:ARBA00025327,
CC       ECO:0000256|RuleBase:RU365028}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000256|ARBA:ARBA00004128};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004128}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. Cation/proton exchanger (CAX) subfamily.
CC       {ECO:0000256|ARBA:ARBA00008248}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU365028}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAK8921702.1}.
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DR   EMBL; JBBWWQ010000018; KAK8921702.1; -; Genomic_DNA.
DR   Proteomes; UP001418222; Unassembled WGS sequence.
DR   FunFam; 1.20.1420.30:FF:000008; Vacuolar cation/proton exchanger; 1.
DR   Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR   InterPro; IPR004713; CaH_exchang.
DR   InterPro; IPR004798; CAX-like.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   NCBIfam; TIGR00378; cax; 1.
DR   PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR   PANTHER; PTHR31503:SF1; VACUOLAR CATION_PROTON EXCHANGER 3; 1.
DR   Pfam; PF01699; Na_Ca_ex; 2.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449, ECO:0000256|RuleBase:RU365028};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU365028};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW   ECO:0000256|RuleBase:RU365028};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU365028};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365028};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365028};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365028}; Transport {ECO:0000256|RuleBase:RU365028};
KW   Vacuole {ECO:0000256|ARBA:ARBA00022554, ECO:0000256|RuleBase:RU365028}.
FT   TRANSMEM        86..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        132..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        163..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        205..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        234..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        282..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        353..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365028"
FT   DOMAIN          98..257
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   DOMAIN          289..431
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
SQ   SEQUENCE   449 AA;  48454 MW;  C3D29106B54C31C9 CRC64;
     MASTTYDAVE ASYVVLLKEE GGRELSKEVG LLQGRKPHMT SSMSLRTKSA LSLSSRVSSS
     FLRNVCINLQ EVFGTKLALL FPAVPLAVAA QCYGFGHAWV FTLSLLGLIP LAERLSFLTE
     QISFYTGPTV SGLLNATCGN APELIIAIFA LQKGCIDLVK FSLVGSILSN LLLVLGTSLF
     CGGVANLGQE QLYNRKQTDA NMSLLLMSAL SHVLLLMFRY VVNYGEHDVL TFPTLTLSRV
     GSLVMLTAYI AFIFFQLKTH RQFFESREVN GDDDNVEFGD EAVIGIASAF AWLIGATLVI
     AVLSEYIVGT IEEASESWGL SVSFISIILL PTVGNAPEHA GAVIFAVKNK LDITLGVSLG
     SATQISMFVV PLSVIVAWVM GIEMDLDFKT LETSSLAFSI LLTAFALQDG ASHYFKGLIL
     LLAYIVIASC FFVFKTPNGN ISMLIATPT
//