ID A0AAP0B0B5_9ASPA Unreviewed; 449 AA. AC A0AAP0B0B5; DT 02-OCT-2024, integrated into UniProtKB/TrEMBL. DT 02-OCT-2024, sequence version 1. DT 27-NOV-2024, entry version 2. DE RecName: Full=Vacuolar cation/proton exchanger {ECO:0000256|RuleBase:RU365028}; GN Name=CAX1a {ECO:0000313|EMBL:KAK8921702.1}; GN ORFNames=KSP39_PZI020250 {ECO:0000313|EMBL:KAK8921702.1}; OS Platanthera zijinensis. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Orchidaceae; OC Orchidoideae; Orchideae; Orchidinae; Platanthera. OX NCBI_TaxID=2320716 {ECO:0000313|EMBL:KAK8921702.1, ECO:0000313|Proteomes:UP001418222}; RN [1] {ECO:0000313|EMBL:KAK8921702.1, ECO:0000313|Proteomes:UP001418222} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Lor287 {ECO:0000313|EMBL:KAK8921702.1}; RX PubMed=35449401; RA Li M.H., Liu K.W., Li Z., Lu H.C., Ye Q.L., Zhang D., Wang J.Y., Li Y.F., RA Zhong Z.M., Liu X., Yu X., Liu D.K., Tu X.D., Liu B., Hao Y., Liao X.Y., RA Jiang Y.T., Sun W.H., Chen J., Chen Y.Q., Ai Y., Zhai J.W., Wu S.S., RA Zhou Z., Hsiao Y.Y., Wu W.L., Chen Y.Y., Lin Y.F., Hsu J.L., Li C.Y., RA Wang Z.W., Zhao X., Zhong W.Y., Ma X.K., Ma L., Huang J., Chen G.Z., RA Huang M.Z., Huang L., Peng D.H., Luo Y.B., Zou S.Q., Chen S.P., Lan S., RA Tsai W.C., Van de Peer Y., Liu Z.J.; RT "Genomes of leafy and leafless Platanthera orchids illuminate the evolution RT of mycoheterotrophy."; RL Nat. Plants 8:373-388(2022). CC -!- FUNCTION: Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+) CC and other metal ions into vacuoles using the proton gradient formed by CC H(+)-ATPase and H(+)-pyrophosphatase. {ECO:0000256|ARBA:ARBA00025327, CC ECO:0000256|RuleBase:RU365028}. CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000256|ARBA:ARBA00004128}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004128}. CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) CC family. Cation/proton exchanger (CAX) subfamily. CC {ECO:0000256|ARBA:ARBA00008248}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|RuleBase:RU365028}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAK8921702.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JBBWWQ010000018; KAK8921702.1; -; Genomic_DNA. DR Proteomes; UP001418222; Unassembled WGS sequence. DR FunFam; 1.20.1420.30:FF:000008; Vacuolar cation/proton exchanger; 1. DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2. DR InterPro; IPR004713; CaH_exchang. DR InterPro; IPR004798; CAX-like. DR InterPro; IPR004837; NaCa_Exmemb. DR InterPro; IPR044880; NCX_ion-bd_dom_sf. DR NCBIfam; TIGR00378; cax; 1. DR PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1. DR PANTHER; PTHR31503:SF1; VACUOLAR CATION_PROTON EXCHANGER 3; 1. DR Pfam; PF01699; Na_Ca_ex; 2. PE 3: Inferred from homology; KW Antiport {ECO:0000256|ARBA:ARBA00022449, ECO:0000256|RuleBase:RU365028}; KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU365028}; KW Calcium transport {ECO:0000256|ARBA:ARBA00022568, KW ECO:0000256|RuleBase:RU365028}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, KW ECO:0000256|RuleBase:RU365028}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365028}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU365028}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU365028}; Transport {ECO:0000256|RuleBase:RU365028}; KW Vacuole {ECO:0000256|ARBA:ARBA00022554, ECO:0000256|RuleBase:RU365028}. FT TRANSMEM 86..112 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU365028" FT TRANSMEM 132..151 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU365028" FT TRANSMEM 163..185 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU365028" FT TRANSMEM 205..222 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU365028" FT TRANSMEM 234..255 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU365028" FT TRANSMEM 282..303 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU365028" FT TRANSMEM 353..379 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU365028" FT TRANSMEM 414..434 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU365028" FT DOMAIN 98..257 FT /note="Sodium/calcium exchanger membrane region" FT /evidence="ECO:0000259|Pfam:PF01699" FT DOMAIN 289..431 FT /note="Sodium/calcium exchanger membrane region" FT /evidence="ECO:0000259|Pfam:PF01699" SQ SEQUENCE 449 AA; 48454 MW; C3D29106B54C31C9 CRC64; MASTTYDAVE ASYVVLLKEE GGRELSKEVG LLQGRKPHMT SSMSLRTKSA LSLSSRVSSS FLRNVCINLQ EVFGTKLALL FPAVPLAVAA QCYGFGHAWV FTLSLLGLIP LAERLSFLTE QISFYTGPTV SGLLNATCGN APELIIAIFA LQKGCIDLVK FSLVGSILSN LLLVLGTSLF CGGVANLGQE QLYNRKQTDA NMSLLLMSAL SHVLLLMFRY VVNYGEHDVL TFPTLTLSRV GSLVMLTAYI AFIFFQLKTH RQFFESREVN GDDDNVEFGD EAVIGIASAF AWLIGATLVI AVLSEYIVGT IEEASESWGL SVSFISIILL PTVGNAPEHA GAVIFAVKNK LDITLGVSLG SATQISMFVV PLSVIVAWVM GIEMDLDFKT LETSSLAFSI LLTAFALQDG ASHYFKGLIL LLAYIVIASC FFVFKTPNGN ISMLIATPT //