ID A0AAN8NPZ5_9PEZI Unreviewed; 786 AA. AC A0AAN8NPZ5; DT 02-OCT-2024, integrated into UniProtKB/TrEMBL. DT 02-OCT-2024, sequence version 1. DT 27-NOV-2024, entry version 2. DE SubName: Full=Serine/threonine-protein kinase Nek2 {ECO:0000313|EMBL:KAK6518700.1}; GN Name=NEK2 {ECO:0000313|EMBL:KAK6518700.1}; GN ORFNames=TWF506_005838 {ECO:0000313|EMBL:KAK6518700.1}; OS Arthrobotrys conoides. OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Orbiliomycetes; OC Orbiliales; Orbiliaceae; Arthrobotrys. OX NCBI_TaxID=74498 {ECO:0000313|EMBL:KAK6518700.1, ECO:0000313|Proteomes:UP001307849}; RN [1] {ECO:0000313|EMBL:KAK6518700.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=TWF506 {ECO:0000313|EMBL:KAK6518700.1}; RA Palmer J.M.; RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr CC protein kinase family. NIMA subfamily. {ECO:0000256|ARBA:ARBA00010886}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAK6518700.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JAVHJM010000002; KAK6518700.1; -; Genomic_DNA. DR Proteomes; UP001307849; Unassembled WGS sequence. DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW. DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW. DR CDD; cd00180; PKc; 1. DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR050660; NEK_Ser/Thr_kinase. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR PANTHER; PTHR43671:SF13; LD04361P; 1. DR PANTHER; PTHR43671; SERINE/THREONINE-PROTEIN KINASE NEK; 1. DR Pfam; PF00023; Ank; 1. DR Pfam; PF12796; Ank_2; 1. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00248; ANK; 4. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF48403; Ankyrin repeat; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS50297; ANK_REP_REGION; 2. DR PROSITE; PS50088; ANK_REPEAT; 2. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 3: Inferred from homology; KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:KAK6518700.1}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU10141}; Transferase {ECO:0000313|EMBL:KAK6518700.1}. FT DOMAIN 89..388 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT REPEAT 628..660 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 698..730 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REGION 430..502 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 448..471 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 118 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141" SQ SEQUENCE 786 AA; 86482 MW; 7D13E366C97D983F CRC64; MFLWRSRPAA EPEAAAPAPA PVAPLITTSP TSAAPLPARP VISANSISVT FSTSDFAIIK GTLGRIDDRT KTDGQKAGPR KLKGKDTDYE YIQHLGQGSY GNVSKVRRAK DGKIMACKTI DCARNPQLYD FTCREVDIWS SFKNEKYIAQ YAQDYSWNPS TKSMRLYMEF YEGGDLQKVL EACRADEVAI HPLVATYWAT EIARGLKNCH DRGVVHKDLK PSNVLLSMPY VYNDMLWTAT LGENLTEKEK QLAGQFTQWL KTRSPWCHIS DFGVGKNSKG GLNGESPVSL STETTYVPPE CVDSAAKYTT KSNVFSLGRI LYALCQCDLP VDTPLEDIQP LPVEYPERLR ALIPRCLKTD PAERPTASEV VLELMESLVD FCCDNQFLKL KSNIDRQINP TRPIARTRTL SSASTLANVY TALNGAIADT TTTERPTSPA VLSVSDIDPI SRTGTPSQEP RKSTSSPTVK HVSLAVIPEQ ASPTVGPSAP PAPAQPPAKT AEELREDLVK AWHSRDINAM ERALVAGADA NTVARSWPKI GITTEYPLLN WTIKDGWSKM MRLLVTHGAT FDAPISDIVT KLSTQTEVKS FQNQYHPIYL AVFIADFGIL DFFFVEQGYN VNSQHLERGD TPLHIAVMRQ DLRVVKYLLQ KGASTEFRNE FGESGVHQAA RSWGTKVNPC LEYLLEVFPD GVNEVDASGN TPLHIAAKDG CLEGIKVLLR KGAKTTVRNE EGSTPEMLAI GRQSIAQALR EAEGLVPIKE KDEFTPEMSV GVMPVMSVLT NPSVVA //