ID A0AAN8LDI2_9TELE Unreviewed; 476 AA. AC A0AAN8LDI2; DT 02-OCT-2024, integrated into UniProtKB/TrEMBL. DT 02-OCT-2024, sequence version 1. DT 27-NOV-2024, entry version 2. DE RecName: Full=Hedgehog protein {ECO:0000256|RuleBase:RU280812}; GN ORFNames=J4Q44_G00217010 {ECO:0000313|EMBL:KAK6308430.1}; OS Coregonus suidteri. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes; OC Salmonidae; Coregoninae; Coregonus. OX NCBI_TaxID=861788 {ECO:0000313|EMBL:KAK6308430.1, ECO:0000313|Proteomes:UP001356427}; RN [1] {ECO:0000313|EMBL:KAK6308430.1, ECO:0000313|Proteomes:UP001356427} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Cs_M1 {ECO:0000313|EMBL:KAK6308430.1}; RC TISSUE=Blood {ECO:0000313|EMBL:KAK6308430.1}; RA De Guttry C., Zahm M., Klopp C., Cabau C., Louis A., Berthelot C., RA Parey E., Roest Crollius H., Montfort J., Robinson-Rechavi M., Bucao C., RA Bouchez O., Gislard M., Lluch J., Milhes M., Lampietro C., Lopez Roques C., RA Donnadieu C., Braasch I., Desvignes T., Postlethwait J., Bobe J., RA Wedekind C., Guiguen Y.; RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: [Protein hedgehog N-product]: The dually lipidated hedgehog CC protein N-product is a morphogen which is essential for a variety of CC patterning events during development. {ECO:0000256|RuleBase:RU280812}. CC -!- FUNCTION: [Protein hedgehog]: The C-terminal part of the hedgehog CC protein precursor displays an autoproteolysis activity that results in CC the cleavage of the full-length protein into two parts (N-product and CC C-product). In addition, the C-terminal part displays a cholesterol CC transferase activity that results by the covalent attachment of a CC cholesterol moiety to the C-terminal of the newly generated N-product. CC {ECO:0000256|RuleBase:RU280812}. CC -!- CATALYTIC ACTIVITY: CC Reaction=glycyl-L-cysteinyl-[protein] + cholesterol + H(+) = [protein]- CC C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl- CC [protein]; Xref=Rhea:RHEA:59504, Rhea:RHEA-COMP:12707, Rhea:RHEA- CC COMP:15369, Rhea:RHEA-COMP:15374, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:16113, ChEBI:CHEBI:65250, ChEBI:CHEBI:143135, CC ChEBI:CHEBI:143140; Evidence={ECO:0000256|ARBA:ARBA00034065}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59505; CC Evidence={ECO:0000256|ARBA:ARBA00034065}; CC -!- SUBUNIT: Multimer. {ECO:0000256|ARBA:ARBA00034131}. CC -!- SUBCELLULAR LOCATION: [Sonic hedgehog protein]: Endoplasmic reticulum CC membrane {ECO:0000256|RuleBase:RU280812}. Golgi apparatus membrane CC {ECO:0000256|RuleBase:RU280812}. CC -!- SUBCELLULAR LOCATION: [Protein hedgehog N-product]: Cell membrane CC {ECO:0000256|RuleBase:RU280812}; Lipid-anchor CC {ECO:0000256|RuleBase:RU280812}. CC -!- SIMILARITY: Belongs to the hedgehog family. CC {ECO:0000256|ARBA:ARBA00010649, ECO:0000256|RuleBase:RU280812}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAK6308430.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JAGTTL010000019; KAK6308430.1; -; Genomic_DNA. DR Proteomes; UP001356427; Unassembled WGS sequence. DR CDD; cd00081; Hint; 1. DR FunFam; 2.170.16.10:FF:000001; Indian hedgehog; 1. DR FunFam; 3.30.1380.10:FF:000001; Indian hedgehog; 1. DR Gene3D; 3.30.1380.10; -; 1. DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1. DR InterPro; IPR001657; Hedgehog. DR InterPro; IPR001767; Hedgehog_Hint. DR InterPro; IPR009045; Hedgehog_sig/DD-Pept_Zn-bd_sf. DR InterPro; IPR050387; Hedgehog_Signaling. DR InterPro; IPR000320; Hedgehog_signalling_dom. DR InterPro; IPR003586; Hint_dom_C. DR InterPro; IPR003587; Hint_dom_N. DR InterPro; IPR036844; Hint_dom_sf. DR InterPro; IPR006141; Intein_N. DR PANTHER; PTHR11889; HEDGEHOG; 1. DR PANTHER; PTHR11889:SF84; HEDGEHOG PROTEIN; 1. DR Pfam; PF01085; HH_signal; 1. DR Pfam; PF01079; Hint; 1. DR PIRSF; PIRSF009400; Peptidase_C46; 1. DR PRINTS; PR00632; SONICHHOG. DR SMART; SM00305; HintC; 1. DR SMART; SM00306; HintN; 1. DR SUPFAM; SSF55166; Hedgehog/DD-peptidase; 1. DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1. DR PROSITE; PS50817; INTEIN_N_TER; 1. DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1. PE 3: Inferred from homology; KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813, KW ECO:0000256|RuleBase:RU280812}; Calcium {ECO:0000256|ARBA:ARBA00022837}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, KW ECO:0000256|RuleBase:RU280812}; KW Developmental protein {ECO:0000256|ARBA:ARBA00022473, KW ECO:0000256|RuleBase:RU280812}; KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU280812}; KW Golgi apparatus {ECO:0000256|RuleBase:RU280812}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU280812}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280812}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Palmitate {ECO:0000256|ARBA:ARBA00023139}; KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU280812}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280812}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}. FT SIGNAL 1..27 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 28..476 FT /note="Hedgehog protein" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5042962984" FT DOMAIN 200..306 FT /note="Hint" FT /evidence="ECO:0000259|SMART:SM00306" FT DOMAIN 308..352 FT /note="Hint" FT /evidence="ECO:0000259|SMART:SM00305" SQ SEQUENCE 476 AA; 53234 MW; DC14552D1659DC30 CRC64; MKVSSWWESL ARLGLLAIFT WSSLVQGCGP GPGYGNRPRP RKLTPMPYKT SFPKLSENNL GASGRVEGKI TRNSERFNEL VCNYNTDIIF KDEEKTLADR FMTKRCKDCL NKLAIAVMNH WPGTKLRVTE AWDEDGHHPP DSLHYEGRAV DITTSDRIPD KYGMLAQLAV EAGFDFVYYE SKYHVHCSVK ADHSVTVEKG GCFPGWARVT LAGGEQKTLA SLEPGDRVLA LSGSGHIVLS RVLLFLHQDH ESRSTFLVLA TKDGRRLALT PHHLVFLAPQ YKLHHSEYQA QFASRAKPGD YVLIHGADGR VQPSRISSVS QEEGMGVYAP LTEHGTLFVG GVLASSYALI EDHRLAHWAF GPLRLLLSFT QLVRGEGTLG AQVTEAEREH TKTPTHCNTQ QKSLRVCVNQ TLRSPGVYMN TNTSDRQSSW AAVPINRDIE GGHCDSVQEK VLSVHWYARL LHRLGQFFLD PKTFHH //