ID A0AAN5D2X0_9BILA Unreviewed; 439 AA. AC A0AAN5D2X0; DT 02-OCT-2024, integrated into UniProtKB/TrEMBL. DT 02-OCT-2024, sequence version 1. DT 27-NOV-2024, entry version 2. DE RecName: Full=non-specific protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011903}; DE EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903}; DE Flags: Fragment; GN ORFNames=PMAYCL1PPCAC_26046 {ECO:0000313|EMBL:GMR55851.1}; OS Pristionchus mayeri. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Diplogasteromorpha; Diplogasteroidea; Neodiplogasteridae; OC Pristionchus. OX NCBI_TaxID=1317129 {ECO:0000313|EMBL:GMR55851.1, ECO:0000313|Proteomes:UP001328107}; RN [1] {ECO:0000313|Proteomes:UP001328107} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RS5460 {ECO:0000313|Proteomes:UP001328107}; RA Yoshida K., Sommer R.J.; RT "Genome assembly of Pristionchus species."; RL Submitted (OCT-2022) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + CC ADP + H(+); Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; CC Evidence={ECO:0000256|ARBA:ARBA00001149}; CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:GMR55851.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BTRK01000005; GMR55851.1; -; Genomic_DNA. DR Proteomes; UP001328107; Unassembled WGS sequence. DR CDD; cd00192; PTKc; 1. DR Gene3D; 3.30.505.10; SH2 domain; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR050198; Non-receptor_tyrosine_kinases. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR000980; SH2. DR InterPro; IPR036860; SH2_dom_sf. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1. DR PANTHER; PTHR24418:SF398; TYROSINE-PROTEIN KINASE; 1. DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1. DR Pfam; PF00017; SH2; 1. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR SUPFAM; SSF55550; SH2 domain; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. DR PROSITE; PS50001; SH2; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141}; KW Kinase {ECO:0000256|ARBA:ARBA00022777}; KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141}; KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}. FT DOMAIN 44..153 FT /note="SH2" FT /evidence="ECO:0000259|PROSITE:PS50001" FT DOMAIN 165..415 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT REGION 1..73 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..23 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 197 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:GMR55851.1" SQ SEQUENCE 439 AA; 49779 MW; 5657444CBB84FB86 CRC64; QKDTSSSSSD KDTKPAPDAK PKKAPKKKGS KKKPEASKTE STVAYSNRLQ EGKDKAPPKV TKRSKKTNKG AQEEGQFLLR KDLEGQAAAP DVILLSVRLG QQVLNALIRE VPSGYRIGDR EFDTVAALVD YYQIRKIAIS ITESLEVTLG NPCRRKSWEL RHKMITVQKE LGSGSYGVVY LALLTYPRQK PITVAAKMLT DMDNDSSHAL WKEARVMQEY DHPNITKFYG VCNDALPYYL VMEFISGGSV DNYLKDNPKL NVYKRTKMAM EAAAGLDYLH SRLCIHRDIA ARNLLIDKVA KVSDFGLTRK TRNYKIDVDK PLNLRWIAPD VYESSTVNKA TDVYAFGITL FEMFVVPYAI PYENWDADQV YENVIEKGMR LQPPREMPKE IQGLMKECLL AAHLRPTFRM IHIFLQALLK KMQADGLEEE GKKKFKLFG //