ID A0AAN1HQD5_9ACTN Unreviewed; 620 AA. AC A0AAN1HQD5; DT 02-OCT-2024, integrated into UniProtKB/TrEMBL. DT 02-OCT-2024, sequence version 1. DT 27-NOV-2024, entry version 2. DE SubName: Full=Serine/threonine-protein kinase PrkC {ECO:0000313|EMBL:AUA13102.1}; DE EC=2.7.11.1 {ECO:0000313|EMBL:AUA13102.1}; GN Name=prkC_4 {ECO:0000313|EMBL:AUA13102.1}; GN ORFNames=CFP59_05257 {ECO:0000313|EMBL:AUA13102.1}; OS Streptomyces sp. M56. OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; OC Streptomycetaceae; Streptomyces. OX NCBI_TaxID=1495638 {ECO:0000313|EMBL:AUA13102.1, ECO:0000313|Proteomes:UP000232019}; RN [1] {ECO:0000313|EMBL:AUA13102.1, ECO:0000313|Proteomes:UP000232019} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=M56 {ECO:0000313|EMBL:AUA13102.1, RC ECO:0000313|Proteomes:UP000232019}; RA Kim K.K.Hyun., Klassen J.L., Ruzzini A.A.C., Beemelmanns C.C., Clardy J.J.; RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + CC H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CC Evidence={ECO:0000256|ARBA:ARBA00001433}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + CC ADP + H(+); Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA- CC COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; CC Evidence={ECO:0000256|ARBA:ARBA00000775}; CC -!- SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr CC protein kinase family. NIMA subfamily. {ECO:0000256|ARBA:ARBA00010886}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP025018; AUA13102.1; -; Genomic_DNA. DR Proteomes; UP000232019; Chromosome. DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW. DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW. DR CDD; cd14014; STKc_PknB_like; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR050660; NEK_Ser/Thr_kinase. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR PANTHER; PTHR43671:SF13; LD04361P; 1. DR PANTHER; PTHR43671; SERINE/THREONINE-PROTEIN KINASE NEK; 1. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:AUA13102.1}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU10141}; Transferase {ECO:0000313|EMBL:AUA13102.1}. FT DOMAIN 127..394 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT REGION 1..122 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 18..40 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 68..91 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 156 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141" SQ SEQUENCE 620 AA; 65986 MW; 4F98DEBA5E015340 CRC64; MTNDGGRANE PTSYSLRPPH APAAPVPAPQ PPPEASDAPP QGSRPPGRAA EAAVPARSAY EPTQFADPRG GPQPPTGEPP TGEPPTGEPP AGELPTGDRS AEEPSAGRQP AAGAQDPNSG RLIGGRYQLV SRLGHGGMGT VWRAHDQIVD RDVAVKEPRV PDHLPERERQ TVYQRMQREA RAAARIDHPS VVTVHDVVVE GGRPWIVMEL VRGQSLGDRL MEGTLDPREA ARIGLSVLGA LAAAHEAGVL HRDVKPDNVL LGRSGRVVLT DFGIAQIEGE QRLTETGGFV GSPEFIAPER VLGQRPGPES DLWSLGVVLY AAVEGMSPFR RSHAPATLQA VLGSEPQVPA RATGPLATLI MQLLRKDPAM RPAAPEVRQA LEAAAKEPQP VPTMLATAGY APGGAQRSAG GRFVPPILHK NRKAQLGLGG LVLVVAAALV LTIMKPFSGE GLPPGWTVRE ERDVVGASLA VPGEYRRVQD DSDSDNPVVT YYDPSGVFTV SLKRSTPDGE NDPASLDAAA DQIVAFYKDG GGATVEEAKS EQTEAGQQGK AARDVTTSYL PYGTSSNKNP IRYVKRDHLY LNKAKVAWDL TVTMPAHGDA QERGEELYER IVRNLRIDQL //