ID A0AAF3FT82_9BILA Unreviewed; 621 AA. AC A0AAF3FT82; DT 29-MAY-2024, integrated into UniProtKB/TrEMBL. DT 29-MAY-2024, sequence version 1. DT 02-OCT-2024, entry version 3. DE RecName: Full=isopentenyl-diphosphate Delta-isomerase {ECO:0000256|ARBA:ARBA00012057}; DE EC=5.3.3.2 {ECO:0000256|ARBA:ARBA00012057}; OS Mesorhabditis belari. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Mesorhabditinae; OC Mesorhabditis. OX NCBI_TaxID=2138241 {ECO:0000313|Proteomes:UP000887575, ECO:0000313|WBParaSite:MBELARI_LOCUS9003}; RN [1] {ECO:0000313|WBParaSite:MBELARI_LOCUS9003} RP IDENTIFICATION. RG WormBaseParasite; RL Submitted (FEB-2024) to UniProtKB. CC -!- FUNCTION: Catalyzes the 1,3-allylic rearrangement of the homoallylic CC substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, CC dimethylallyl diphosphate (DMAPP). {ECO:0000256|ARBA:ARBA00003951}. CC -!- CATALYTIC ACTIVITY: CC Reaction=isopentenyl diphosphate = dimethylallyl diphosphate; CC Xref=Rhea:RHEA:23284, ChEBI:CHEBI:57623, ChEBI:CHEBI:128769; CC EC=5.3.3.2; Evidence={ECO:0000256|ARBA:ARBA00000374}; CC -!- PATHWAY: Isoprenoid biosynthesis; dimethylallyl diphosphate CC biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: CC step 1/1. {ECO:0000256|ARBA:ARBA00004826}. CC -!- SIMILARITY: Belongs to the IPP isomerase type 1 family. CC {ECO:0000256|ARBA:ARBA00007579}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR WBParaSite; MBELARI_LOCUS9003; MBELARI_LOCUS9003; MBELARI_LOCUS9003. DR Proteomes; UP000887575; Unplaced. DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter. DR GO; GO:0004452; F:isopentenyl-diphosphate delta-isomerase activity; IEA:InterPro. DR GO; GO:0009240; P:isopentenyl diphosphate biosynthetic process; IEA:TreeGrafter. DR CDD; cd02885; IPP_Isomerase; 1. DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1. DR InterPro; IPR011876; IsopentenylPP_isomerase_typ1. DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf. DR InterPro; IPR000086; NUDIX_hydrolase_dom. DR InterPro; IPR024336; tRNA_splic_suSen54_N. DR NCBIfam; TIGR02150; IPP_isom_1; 1. DR PANTHER; PTHR10885; ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE; 1. DR PANTHER; PTHR10885:SF0; ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE; 1. DR Pfam; PF00293; NUDIX; 1. DR Pfam; PF12928; tRNA_int_end_N2; 1. DR SUPFAM; SSF55811; Nudix; 1. DR PROSITE; PS51462; NUDIX; 1. PE 3: Inferred from homology; KW Isomerase {ECO:0000256|ARBA:ARBA00023235}; KW Isoprene biosynthesis {ECO:0000256|ARBA:ARBA00023229}; KW Reference proteome {ECO:0000313|Proteomes:UP000887575}. FT DOMAIN 61..207 FT /note="Nudix hydrolase" FT /evidence="ECO:0000259|PROSITE:PS51462" SQ SEQUENCE 621 AA; 71056 MW; AE21E65A593AF373 CRC64; MLFRPSSLIR LATRKMNIEA LAQADPIQAQ HMKEVCIAVN ESDVPEEAIP KCDAHHIESL TLHRAFSVFA FTPDHRLLLQ KRSKHKITFP EMWTNTCCSH PLWNDAELKG VEGAKAAAKR KMEHELGIKA IEDDRYLFKG KYLYKAMMPN SPWGEHEMDY VLILRNFDLS RIEVNAEEVE NYAVVSLEEL KKRLANPNCN FTPWQNWRRM KRKQDQPSKQ KAKRLEQFNE PGSLAKKKSI IHIEYNNATS KWEVTRQATK YLQTMGVPGV KGAPQTLYPE EVFYLYEIGS AIVKEKEGRQ LIGTEVLALA LRAISFSCLM TYREMRRAGF VVVRKRLHPT EPVAQTQATP SISYFDEKAN KPSTSEPTIN ILAETKKSPS EPANASLSLK PFSSTVLDMF PTLENGKMKM IHLATDQNLS PMHEPISSRI VSPNVIRLTP DVDRPKMMKR LSTPLAPRFW PNLEELATTA STWSEYREKF KRTMEMNEQR AFNRYNSFKS PFQISRGGPA PRRGFSRAPF HANTSYTPRP FQRTPLMPKV KQQMGVEYDI YKAGTFMHTV VTPPFMRMTV LESSCGNVLS SANPDPTIRS IFAMVSADSV ITYIEHSNNP ITLQEMEKFV Q //