ID A0AAE2BUS2_9LAMI Unreviewed; 425 AA. AC A0AAE2BUS2; DT 29-MAY-2024, integrated into UniProtKB/TrEMBL. DT 29-MAY-2024, sequence version 1. DT 27-NOV-2024, entry version 4. DE RecName: Full=aspartate carbamoyltransferase {ECO:0000256|ARBA:ARBA00013008}; DE EC=2.1.3.2 {ECO:0000256|ARBA:ARBA00013008}; GN ORFNames=Sango_1330900 {ECO:0000313|EMBL:KAK4398554.1}; OS Sesamum angolense. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC asterids; lamiids; Lamiales; Pedaliaceae; Sesamum. OX NCBI_TaxID=2727404 {ECO:0000313|EMBL:KAK4398554.1, ECO:0000313|Proteomes:UP001289374}; RN [1] {ECO:0000313|EMBL:KAK4398554.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=K16 {ECO:0000313|EMBL:KAK4398554.1}; RC TISSUE=Leaf {ECO:0000313|EMBL:KAK4398554.1}; RA Li T., Hu X., Zhang T., Song X., Zhang H., Dai N., Sheng W., Hou X., RA Wei L.; RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:KAK4398554.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=K16 {ECO:0000313|EMBL:KAK4398554.1}; RX PubMed=37798879; RA Miao H., Wang L., Qu L., Liu H., Sun Y., Le M., Wang Q., Wei S., Zheng Y., RA Lin W., Duan Y., Cao H., Xiong S., Wang X., Wei L., Li C., Ma Q., Ju M., RA Zhao R., Li G., Mu C., Tian Q., Mei H., Zhang T., Gao T., Zhang H.; RT "Genomic evolution and insights into agronomic trait innovations of Sesamum RT species."; RL Plant 5:0-0(2024). CC -!- FUNCTION: Catalyzes the condensation of carbamoyl phosphate and CC aspartate to form carbamoyl aspartate and inorganic phosphate, the CC committed step in the de novo pyrimidine nucleotide biosynthesis CC pathway. {ECO:0000256|ARBA:ARBA00043884}. CC -!- CATALYTIC ACTIVITY: CC Reaction=carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + CC phosphate + H(+); Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:58228; EC=2.1.3.2; CC Evidence={ECO:0000256|ARBA:ARBA00001363}; CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; CC (S)-dihydroorotate from bicarbonate: step 2/3. CC {ECO:0000256|ARBA:ARBA00004852}. CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}. CC -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase CC superfamily. {ECO:0000256|RuleBase:RU003634}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAK4398554.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JACGWL010000007; KAK4398554.1; -; Genomic_DNA. DR Proteomes; UP001289374; Unassembled WGS sequence. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0016597; F:amino acid binding; IEA:InterPro. DR GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:InterPro. DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro. DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro. DR GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW. DR FunFam; 3.40.50.1370:FF:000001; Aspartate carbamoyltransferase; 1. DR FunFam; 3.40.50.1370:FF:000002; Aspartate carbamoyltransferase 2; 1. DR Gene3D; 3.40.50.1370; Aspartate/ornithine carbamoyltransferase; 2. DR HAMAP; MF_00001; Asp_carb_tr; 1. DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd. DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase. DR InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf. DR InterPro; IPR002082; Asp_carbamoyltransf. DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd. DR NCBIfam; TIGR00670; asp_carb_tr; 1. DR PANTHER; PTHR45753:SF6; ASPARTATE CARBAMOYLTRANSFERASE; 1. DR PANTHER; PTHR45753; ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL; 1. DR Pfam; PF00185; OTCace; 1. DR Pfam; PF02729; OTCace_N; 1. DR PRINTS; PR00100; AOTCASE. DR PRINTS; PR00101; ATCASE. DR SUPFAM; SSF53671; Aspartate/ornithine carbamoyltransferase; 1. DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|SAM:Phobius}; KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975}; KW Reference proteome {ECO:0000313|Proteomes:UP001289374}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003634}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..21 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 22..425 FT /note="aspartate carbamoyltransferase" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5042277317" FT TRANSMEM 399..416 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 109..250 FT /note="Aspartate/ornithine carbamoyltransferase carbamoyl-P FT binding" FT /evidence="ECO:0000259|Pfam:PF02729" FT DOMAIN 257..408 FT /note="Aspartate/ornithine carbamoyltransferase Asp/Orn- FT binding" FT /evidence="ECO:0000259|Pfam:PF00185" SQ SEQUENCE 425 AA; 47493 MW; FD1D8B0059534DDD CRC64; MPLKVVLLTV MASSSTFSAW ALNGGLLVPK VSRNNSEFIC NDLDCCVKRT PFMPTSPSAH VSRSCVFPGA KAIDWRRGKL SPKSGLQCKA LEVDTKHSFS LGNKFQLEDV IEAQQFDRDT LTAIFEVALE MEKIEKNSAG SQILKGYLMA TLFYEPSTRT RLSFESAMKR LGGEVLTTEN AREFSSAAKG ETLEDTIRTV QGYSDIIVMR HFESGAARRA ATTASIPIIN AGDGPGQHPT QALLDVYTIQ REIGKLDGIK VGLVGDLAYG RTVRSLAYLL AKYKDVKIYF VSPEVVKMKD DIKDYLTSRG VEWEESADLL EVASKCDVVY QTRIQRERFG ERIDLYEEAR GKYIVNLDVL NVMQKHAVVM HPLPRLDEIT VDVDVDPRAA YFRQAKNGLY IRMALLKLLL LGVFILDDEA NLLRM //