ID A0AAE1SQX6_9SOLA Unreviewed; 889 AA. AC A0AAE1SQX6; DT 29-MAY-2024, integrated into UniProtKB/TrEMBL. DT 29-MAY-2024, sequence version 1. DT 02-OCT-2024, entry version 3. DE RecName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0008006|Google:ProtNLM}; GN ORFNames=RND71_005152 {ECO:0000313|EMBL:KAK4374475.1}; OS Anisodus tanguticus. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Hyoscyameae; OC Anisodus. OX NCBI_TaxID=243964 {ECO:0000313|EMBL:KAK4374475.1, ECO:0000313|Proteomes:UP001291623}; RN [1] {ECO:0000313|EMBL:KAK4374475.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=KB-2021 {ECO:0000313|EMBL:KAK4374475.1}; RC TISSUE=Leaf {ECO:0000313|EMBL:KAK4374475.1}; RA Wang Y.-J.; RT "Genome assembly of Anisodus tanguticus."; RL Submitted (DEC-2023) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=(3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA; CC Xref=Rhea:RHEA:21760, ChEBI:CHEBI:57315, ChEBI:CHEBI:57316; CC EC=5.1.2.3; Evidence={ECO:0000256|ARBA:ARBA00023701}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA; CC Xref=Rhea:RHEA:45228, ChEBI:CHEBI:58521, ChEBI:CHEBI:85097; CC EC=5.3.3.8; Evidence={ECO:0000256|ARBA:ARBA00000765}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O; CC Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318, CC ChEBI:CHEBI:58856; EC=4.2.1.17; CC Evidence={ECO:0000256|ARBA:ARBA00023709}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA; CC Xref=Rhea:RHEA:45900, ChEBI:CHEBI:85097, ChEBI:CHEBI:85489; CC EC=5.3.3.8; Evidence={ECO:0000256|ARBA:ARBA00000452}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O; CC Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521, CC ChEBI:CHEBI:137480; EC=4.2.1.17; CC Evidence={ECO:0000256|ARBA:ARBA00023717}; CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation. CC {ECO:0000256|ARBA:ARBA00005005}. CC -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. CC {ECO:0000256|ARBA:ARBA00009463}. CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family. CC {ECO:0000256|RuleBase:RU003707}. CC -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA CC hydratase/isomerase family. {ECO:0000256|ARBA:ARBA00008750}. CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAK4374475.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JAVYJV010000003; KAK4374475.1; -; Genomic_DNA. DR Proteomes; UP001291623; Unassembled WGS sequence. DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-KW. DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW. DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:TreeGrafter. DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro. DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:TreeGrafter. DR CDD; cd06558; crotonase-like; 1. DR Gene3D; 1.10.1040.50; -; 1. DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1. DR InterPro; IPR006180; 3-OHacyl-CoA_DH_CS. DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd. DR InterPro; IPR006108; 3HC_DH_C. DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf. DR InterPro; IPR013328; 6PGD_dom2. DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf. DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS. DR InterPro; IPR001753; Enoyl-CoA_hydra/iso. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1. DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1. DR Pfam; PF00725; 3HCDH; 1. DR Pfam; PF02737; 3HCDH_N; 1. DR Pfam; PF00378; ECH_1; 1. DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2. DR SUPFAM; SSF52096; ClpP/crotonase; 1. DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1. DR PROSITE; PS00067; 3HCDH; 1. DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1. PE 3: Inferred from homology; KW Chloroplast {ECO:0000256|ARBA:ARBA00022528}; KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832}; KW NAD {ECO:0000256|ARBA:ARBA00023027}; KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}; KW Plastid {ECO:0000256|ARBA:ARBA00022528}; KW Reference proteome {ECO:0000313|Proteomes:UP001291623}. FT DOMAIN 301..466 FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding" FT /evidence="ECO:0000259|Pfam:PF02737" FT DOMAIN 469..560 FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal" FT /evidence="ECO:0000259|Pfam:PF00725" FT REGION 857..889 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 873..889 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 889 AA; 97897 MW; CEB28D09ED913E0C CRC64; MVAIQKEEVG GDGVAVITII NPPVNSLALD LLYSLKESYE QALRRDDVKA IVVTGAARVF LANFSLFTVE SPKPGFISVE ILTDTVEAAR KPSVAAIDGL ALGGGLEVAM ACHARISTPN AQLGLPELQL GILPGFGTQR LPRLVGLAKS LEMMLTSKPV KGEEAVNLGL VDAVVPSNQL LDTARKWALD ILECRKPWIA SLHKTDKIEP LGEAKEILKF ARVQTRRQAP NLQHPLVVID VVEEGIVSGP HAGLWKEAEA FQGLLHSDTC KALVNVFFAQ RGTTKVPGVT DLGLKPRRIK KVAILGGGLM GSGIATALLL SNYPVMLKEV NDKFLQAGLG RVKVERSLKK LSLLKGALDY EGFRDVDMVI EAVIENVSLK QQIFADLEKY CPPHCILASN TSTIDLDLIG VKTKSQDRII GAHFFSPAHV MPLLEIVRTE KTSPQVIVDL LDVGKKIRKT PVVVGNCTGF AVNRMFFPYT QDALLLVERG TDVFRIDRVI TKFGMPMGPF RLCDLVGFGV AIATGGQFVM NFPERTYKSM LIPLMQEDKR AGETTRRGFY MAKLSDKDII EMIFFPVVNE ACRVLAEGIA VKASDLDISA IMGMGFPPYR GGIIFWADTL GSKYVCSILD EWSRMYGDFF KPCSYLAERA AKGAHLHILD YSNQSLGHRF IETHPSLFDA RVLQQIQPSR SCKISNAREH SSVRSFVFFL TLKRILVISS LFIILKALFF HSSTISREKK KEEIVVVEEN ESPNEASFNN KVARSKSVGC GSRSFSGDLF EKISTGFGDC TLRRIKSQRE NKPRFSSVHH KERVNCGGIL SYLVSSEVNN MNGRSHHISN GRSKNWGWAL ASPMRAFSKT SSSEKKEDSN NKNSTPNLDA TPSLLTVRS //