ID   A0AAE1SQX6_9SOLA        Unreviewed;       889 AA.
AC   A0AAE1SQX6;
DT   29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2024, sequence version 1.
DT   24-JUL-2024, entry version 2.
DE   RecName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=RND71_005152 {ECO:0000313|EMBL:KAK4374475.1};
OS   Anisodus tanguticus.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Hyoscyameae;
OC   Anisodus.
OX   NCBI_TaxID=243964 {ECO:0000313|EMBL:KAK4374475.1, ECO:0000313|Proteomes:UP001291623};
RN   [1] {ECO:0000313|EMBL:KAK4374475.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KB-2021 {ECO:0000313|EMBL:KAK4374475.1};
RC   TISSUE=Leaf {ECO:0000313|EMBL:KAK4374475.1};
RA   Wang Y.-J.;
RT   "Genome assembly of Anisodus tanguticus.";
RL   Submitted (DEC-2023) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA;
CC         Xref=Rhea:RHEA:21760, ChEBI:CHEBI:57315, ChEBI:CHEBI:57316;
CC         EC=5.1.2.3; Evidence={ECO:0000256|ARBA:ARBA00023701};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA;
CC         Xref=Rhea:RHEA:45228, ChEBI:CHEBI:58521, ChEBI:CHEBI:85097;
CC         EC=5.3.3.8; Evidence={ECO:0000256|ARBA:ARBA00000765};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:58856; EC=4.2.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00023709};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA;
CC         Xref=Rhea:RHEA:45900, ChEBI:CHEBI:85097, ChEBI:CHEBI:85489;
CC         EC=5.3.3.8; Evidence={ECO:0000256|ARBA:ARBA00000452};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521,
CC         ChEBI:CHEBI:137480; EC=4.2.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00023717};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009463}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC       hydratase/isomerase family. {ECO:0000256|ARBA:ARBA00008750}.
CC   -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAK4374475.1}.
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DR   EMBL; JAVYJV010000003; KAK4374475.1; -; Genomic_DNA.
DR   Proteomes; UP001291623; Unassembled WGS sequence.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR   PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Chloroplast {ECO:0000256|ARBA:ARBA00022528};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW   Plastid {ECO:0000256|ARBA:ARBA00022640}.
FT   DOMAIN          301..466
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          469..560
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   REGION          857..889
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        873..889
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   889 AA;  97897 MW;  CEB28D09ED913E0C CRC64;
     MVAIQKEEVG GDGVAVITII NPPVNSLALD LLYSLKESYE QALRRDDVKA IVVTGAARVF
     LANFSLFTVE SPKPGFISVE ILTDTVEAAR KPSVAAIDGL ALGGGLEVAM ACHARISTPN
     AQLGLPELQL GILPGFGTQR LPRLVGLAKS LEMMLTSKPV KGEEAVNLGL VDAVVPSNQL
     LDTARKWALD ILECRKPWIA SLHKTDKIEP LGEAKEILKF ARVQTRRQAP NLQHPLVVID
     VVEEGIVSGP HAGLWKEAEA FQGLLHSDTC KALVNVFFAQ RGTTKVPGVT DLGLKPRRIK
     KVAILGGGLM GSGIATALLL SNYPVMLKEV NDKFLQAGLG RVKVERSLKK LSLLKGALDY
     EGFRDVDMVI EAVIENVSLK QQIFADLEKY CPPHCILASN TSTIDLDLIG VKTKSQDRII
     GAHFFSPAHV MPLLEIVRTE KTSPQVIVDL LDVGKKIRKT PVVVGNCTGF AVNRMFFPYT
     QDALLLVERG TDVFRIDRVI TKFGMPMGPF RLCDLVGFGV AIATGGQFVM NFPERTYKSM
     LIPLMQEDKR AGETTRRGFY MAKLSDKDII EMIFFPVVNE ACRVLAEGIA VKASDLDISA
     IMGMGFPPYR GGIIFWADTL GSKYVCSILD EWSRMYGDFF KPCSYLAERA AKGAHLHILD
     YSNQSLGHRF IETHPSLFDA RVLQQIQPSR SCKISNAREH SSVRSFVFFL TLKRILVISS
     LFIILKALFF HSSTISREKK KEEIVVVEEN ESPNEASFNN KVARSKSVGC GSRSFSGDLF
     EKISTGFGDC TLRRIKSQRE NKPRFSSVHH KERVNCGGIL SYLVSSEVNN MNGRSHHISN
     GRSKNWGWAL ASPMRAFSKT SSSEKKEDSN NKNSTPNLDA TPSLLTVRS
//