ID   A0AAA9SJL0_BOVIN        Unreviewed;       129 AA.
AC   A0AAA9SJL0;
DT   29-MAY-2024, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2024, sequence version 1.
DT   02-OCT-2024, entry version 3.
DE   RecName: Full=N-alpha-acetyltransferase 50 {ECO:0000256|ARBA:ARBA00039544};
DE            EC=2.3.1.258 {ECO:0000256|ARBA:ARBA00039121};
DE   AltName: Full=N-epsilon-acetyltransferase 50 {ECO:0000256|ARBA:ARBA00042533};
DE   AltName: Full=NatE catalytic subunit {ECO:0000256|ARBA:ARBA00042626};
GN   Name=NAA50 {ECO:0000313|Ensembl:ENSBTAP00000086476.1,
GN   ECO:0000313|VGNC:VGNC:53590};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000086476.1, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000086476.1, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000086476.1,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000086476.1}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000086476.1};
RG   Ensembl;
RL   Submitted (JUN-2024) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] = CoA +
CC         H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein];
CC         Xref=Rhea:RHEA:50564, Rhea:RHEA-COMP:12726, Rhea:RHEA-COMP:12727,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:133398, ChEBI:CHEBI:133399; EC=2.3.1.258;
CC         Evidence={ECO:0000256|ARBA:ARBA00036404};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA +
CC         H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein];
CC         Xref=Rhea:RHEA:50520, Rhea:RHEA-COMP:12711, Rhea:RHEA-COMP:12712,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:133377, ChEBI:CHEBI:133378; EC=2.3.1.258;
CC         Evidence={ECO:0000256|ARBA:ARBA00035859};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] = CoA +
CC         H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein];
CC         Xref=Rhea:RHEA:50580, Rhea:RHEA-COMP:12734, Rhea:RHEA-COMP:12735,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:133406, ChEBI:CHEBI:133407; EC=2.3.1.258;
CC         Evidence={ECO:0000256|ARBA:ARBA00036162};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] =
CC         CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-
CC         [protein]; Xref=Rhea:RHEA:50528, Rhea:RHEA-COMP:12715, Rhea:RHEA-
CC         COMP:12716, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:133382, ChEBI:CHEBI:133383; EC=2.3.1.258;
CC         Evidence={ECO:0000256|ARBA:ARBA00036197};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] = CoA +
CC         H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein];
CC         Xref=Rhea:RHEA:50568, Rhea:RHEA-COMP:12728, Rhea:RHEA-COMP:12729,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:133400, ChEBI:CHEBI:133401; EC=2.3.1.258;
CC         Evidence={ECO:0000256|ARBA:ARBA00036718};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] = CoA
CC         + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein];
CC         Xref=Rhea:RHEA:50576, Rhea:RHEA-COMP:12732, Rhea:RHEA-COMP:12733,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:133404, ChEBI:CHEBI:133405; EC=2.3.1.258;
CC         Evidence={ECO:0000256|ARBA:ARBA00036884};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA
CC         + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein];
CC         Xref=Rhea:RHEA:50532, Rhea:RHEA-COMP:12717, Rhea:RHEA-COMP:12718,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:133384, ChEBI:CHEBI:133385; EC=2.3.1.258;
CC         Evidence={ECO:0000256|ARBA:ARBA00036534};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] = CoA +
CC         H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein];
CC         Xref=Rhea:RHEA:50572, Rhea:RHEA-COMP:12730, Rhea:RHEA-COMP:12731,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:133402, ChEBI:CHEBI:133403; EC=2.3.1.258;
CC         Evidence={ECO:0000256|ARBA:ARBA00036417};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the acetyltransferase family. GNAT subfamily.
CC       {ECO:0000256|ARBA:ARBA00009342}.
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DR   SMR; A0AAA9SJL0; -.
DR   Ensembl; ENSBTAT00000127125.1; ENSBTAP00000086476.1; ENSBTAG00000007784.7.
DR   VGNC; VGNC:53590; NAA50.
DR   GeneTree; ENSGT00390000009110; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   Gene3D; 3.40.630.30; -; 2.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000182; GNAT_dom.
DR   InterPro; IPR051556; N-term/lysine_N-AcTrnsfr.
DR   PANTHER; PTHR42919; N-ALPHA-ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR42919:SF8; N-ALPHA-ACETYLTRANSFERASE 50; 1.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          48..115
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS51186"
SQ   SEQUENCE   129 AA;  14886 MW;  D36C0EE340819268 CRC64;
     MKGSRIELGD VTPHNIKQLK RLNQVIFPVS YNDKFYKDVL EVGELAKLGT KMLNHVLNIC
     EKDGTFDNIY LHVQISNESA IDFYRKFGFE IIETKKNYYK RIEPADAHVL QKNLKVPSGQ
     NADVQKTDN
//