ID   A0AA87LQ04_BIFLN        Unreviewed;       663 AA.
AC   A0AA87LQ04;
DT   27-MAR-2024, integrated into UniProtKB/TrEMBL.
DT   27-MAR-2024, sequence version 1.
DT   29-MAY-2024, entry version 2.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   ORFNames=HMPREF1313_0536 {ECO:0000313|EMBL:EIJ25798.1};
OS   Bifidobacterium longum subsp. longum 1-6B.
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=1161744 {ECO:0000313|EMBL:EIJ25798.1, ECO:0000313|Proteomes:UP000006410};
RN   [1] {ECO:0000313|EMBL:EIJ25798.1, ECO:0000313|Proteomes:UP000006410}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1-6B {ECO:0000313|EMBL:EIJ25798.1,
RC   ECO:0000313|Proteomes:UP000006410};
RX   PubMed=23682142;
RA   Shkoporov A.N., Efimov B.A., Khokhlova E.V., Chaplin A.V., Kafarskaya L.I.,
RA   Durkin A.S., McCorrison J., Torralba M., Gillis M., Sutton G., Weibel D.B.,
RA   Nelson K.E., Smeianov V.V.;
RT   "Draft Genome Sequences of Two Pairs of Human Intestinal Bifidobacterium
RT   longum subsp. longum Strains, 44B and 1-6B and 35B and 2-2B, Consecutively
RT   Isolated from Two Children after a 5-Year Time Period.";
RL   Genome Announc. 1:E00234-E00213(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EIJ25798.1}.
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DR   EMBL; AJTF01000080; EIJ25798.1; -; Genomic_DNA.
DR   RefSeq; WP_007055645.1; NZ_AJTF01000080.1.
DR   GeneID; 69578664; -.
DR   Proteomes; UP000006410; Unassembled WGS sequence.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   PANTHER; PTHR45436:SF5; SENSOR HISTIDINE KINASE TRCS; 1.
DR   PANTHER; PTHR45436; SENSOR HISTIDINE KINASE YKOH; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   TRANSMEM        56..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        262..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          286..339
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          354..627
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          630..663
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   663 AA;  71667 MW;  9D6FE529AA35930B CRC64;
     MSIPDKQSGG VPPSSTPNAA PNTNPMPAMS PFAAHFQEQR ERKKNMLMRH IDRISLSSKL
     VACTIAVLLI GVSVISFSIR ALVNNYMLQK TDTQLSSQSQ LVVNNIDLLS KNDSSGPNSY
     FLQIQYTDGT KDKEGNPLVV TPLMPQMQDG IVSVPILPTY GDTNGITLGQ AFTTQAVAKQ
     IITVQSDSAD SQNDPANGNS NSSDTITKVL ANPTANANHA AIVTARAPWR ILPVTFQQNG
     KDRAVVYIGL SLADQIDTVN TLTRYCIVVG IAVVLLGGSL STLIIQHTMT PLKRIEKTAA
     KIAAGDLSQR IPSAPENTEV GSLAASLNSM LTRIESSFHE QEETTDKMKR FVSDASHELR
     TPLAAIHGYA ELYKMQRDMP GALERADESI EHIERSSQRM TVLVEDLLSL ARLDEGRGID
     MTGTVKLSSL VTDAVDDLHA LDPDRAVRRM QISLEPARDL NHPAEFSLAE GDWPEVVLPG
     DASRLRQVVT NIVGNIHRYT PADSPAEAAL GVMPAAIDPR QLARMPASDA SMRRFIDAAE
     VGASMQTGYR YAVLRFVDHG PGVPPESRSK IFERFYTADP SRAREKGGTG LGMAIAQSVV
     KAHHGFICAT GTDGGGLTFT VVLPIEQIAA PEPKQSTGKT KDAKQKTSWF SSERKTQATQ
     PKA
//