ID A0AA49K027_9BACT Unreviewed; 307 AA. AC A0AA49K027; DT 24-JAN-2024, integrated into UniProtKB/TrEMBL. DT 24-JAN-2024, sequence version 1. DT 29-MAY-2024, entry version 3. DE RecName: Full=Malonyl CoA-acyl carrier protein transacylase {ECO:0000256|PIRNR:PIRNR000446}; DE EC=2.3.1.39 {ECO:0000256|PIRNR:PIRNR000446}; GN Name=fabD {ECO:0000313|EMBL:WKW15111.1}; GN ORFNames=Strain318_001484 {ECO:0000313|EMBL:WKW15111.1}; OS Gemmatimonadaceae bacterium 'strain 318'. OC Bacteria; Gemmatimonadota; Gemmatimonadetes; Gemmatimonadales; OC Gemmatimonadaceae. OX NCBI_TaxID=3062599 {ECO:0000313|EMBL:WKW15111.1}; RN [1] {ECO:0000313|EMBL:WKW15111.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Strain 318 {ECO:0000313|EMBL:WKW15111.1}; RA Haufschild T., Kallscheuer N., Hammer J., Kohn T., Kabuu M., Jogler M., RA Wohfarth N., Heuer A., Rohde M., van Teeseling M.C.F., Jogler C.; RL Submitted (JUL-2023) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]; CC Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685, CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479, CC ChEBI:CHEBI:78449; EC=2.3.1.39; CC Evidence={ECO:0000256|ARBA:ARBA00000936, CC ECO:0000256|PIRNR:PIRNR000446}; CC -!- SIMILARITY: Belongs to the fabD family. CC {ECO:0000256|PIRNR:PIRNR000446}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP130613; WKW15111.1; -; Genomic_DNA. DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW. DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1. DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1. DR InterPro; IPR001227; Ac_transferase_dom_sf. DR InterPro; IPR014043; Acyl_transferase. DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase. DR InterPro; IPR024925; Malonyl_CoA-ACP_transAc. DR InterPro; IPR004410; Malonyl_CoA-ACP_transAc_FabD. DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd. DR NCBIfam; TIGR00128; fabD; 1. DR PANTHER; PTHR42681; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1. DR PANTHER; PTHR42681:SF1; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1. DR Pfam; PF00698; Acyl_transf_1; 1. DR PIRSF; PIRSF000446; Mct; 1. DR SMART; SM00827; PKS_AT; 1. DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1. DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1. PE 3: Inferred from homology; KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315, KW ECO:0000256|PIRNR:PIRNR000446}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000446}. FT DOMAIN 4..300 FT /note="Malonyl-CoA:ACP transacylase (MAT)" FT /evidence="ECO:0000259|SMART:SM00827" FT ACT_SITE 89 FT /evidence="ECO:0000256|PIRSR:PIRSR000446-1" FT ACT_SITE 198 FT /evidence="ECO:0000256|PIRSR:PIRSR000446-1" SQ SEQUENCE 307 AA; 31975 MW; F92125FF5D5F8113 CRC64; MILLFPGQGS QKPGMAKDLA EAFPAARDVF ARADAALGAP LSTLCFEGPA EELTLTHNAQ PALLAHGAAV WAVVKDHVAA KVQGAAGHSL GEFSAYHTAG ALSLEDALKL VRRRGELMYE TGVQVPGAMA AILGEMSRTI EEICSEASAR GVVVPANYNA TEQIVISGEV AAVEQAMELA KAAGAKRALR LPVSGAFHSP LMQPAAAGLQ QALDAARWRD PSWPIWSNVT AEAVGDAATA KSLLHQQLTS PVRWVEVVRN LAARFPGTAF VEMGPGAVLS GLVKRLAPGC TTMTCGTVAE VEALLKL //