ID A0A9Q8L472_9BETA Unreviewed; 301 AA. AC A0A9Q8L472; DT 13-SEP-2023, integrated into UniProtKB/TrEMBL. DT 13-SEP-2023, sequence version 1. DT 08-NOV-2023, entry version 2. DE RecName: Full=Envelope glycoprotein L {ECO:0000256|HAMAP-Rule:MF_04036}; DE Short=gL {ECO:0000256|HAMAP-Rule:MF_04036}; GN Name=U82 {ECO:0000313|EMBL:UEH20658.1}; GN Synonyms=gL {ECO:0000256|HAMAP-Rule:MF_04036}; OS Elephant endotheliotropic herpesvirus 6. OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Proboscivirus. OX NCBI_TaxID=768739 {ECO:0000313|EMBL:UEH20658.1, ECO:0000313|Proteomes:UP001142623}; RN [1] {ECO:0000313|EMBL:UEH20658.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NAP35 Miss Bets {ECO:0000313|EMBL:UEH20658.1}; RX PubMed=20579821; DOI=10.1016/j.vetmic.2010.05.042; RA Latimer E, Zong JC, Heaggans SY, Richman LK, Hayward GS.; RT "Detection and evaluation of novel herpesviruses in routine and RT pathological samples from Asian and African elephants: identification of RT two new probosciviruses (EEHV5 and EEHV6) and two new gammaherpesviruses RT (EGHV3B and EGHV5)."; RL Vet. Microbiol. 147:28-41(2011). RN [2] {ECO:0000313|EMBL:UEH20658.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NAP35 Miss Bets {ECO:0000313|EMBL:UEH20658.1}; RX PubMed=23580705; DOI=10.1128/genomeA.00106-13; RA Ling PD, Reid JG, Qin X, Muzny DM, Gibbs R, Petrosino J, Peng R, Zong JC, RA Heaggans SY, Hayward GS.; RT "Complete Genome Sequence of Elephant Endotheliotropic Herpesvirus 1A."; RL Genome Announc. 1:e0010613-e0010613(2013). RN [3] {ECO:0000313|EMBL:UEH20658.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NAP35 Miss Bets {ECO:0000313|EMBL:UEH20658.1}; RX PubMed=25231309; DOI=10.1128/JVI.01675-14; RA Zong JC, Latimer EM, Long SY, Richman LK, Heaggans SY, Hayward GS.; RT "Comparative genome analysis of four elephant endotheliotropic RT herpesviruses, EEHV3, EEHV4, EEHV5, and EEHV6, from cases of hemorrhagic RT disease or viremia."; RL J. Virol. 88:13547-13569(2014). RN [4] {ECO:0000313|EMBL:UEH20658.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NAP35 Miss Bets {ECO:0000313|EMBL:UEH20658.1}; RX PubMed=27340696; RA Ling PD, Long SY, Zong JC, Heaggans SY, Qin X, Hayward GS.; RT "Comparison of the Gene Coding Contents and Other Unusual Features of the RT GC-Rich and AT-Rich Branch Probosciviruses."; RL MSphere 1:e00091-e00016(2016). RN [5] {ECO:0000313|EMBL:UEH20658.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NAP35 Miss Bets {ECO:0000313|EMBL:UEH20658.1}; RA Ling P.D., Tan J., Qin X., Doddapaneni H., Menon V.K., Momin Z., RA Kottapalli K., Heaggans S.Y., Zong J.-C., Latimer E.M., Riddle H., RA Hayward G.S.; RT "Complete genomic DNA sequence of EEHV6 (MB1) from a young African elephant RT that survived acute systemic infection."; RL Submitted (AUG-2021) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The heterodimer glycoprotein H-glycoprotein L is required for CC the fusion of viral and plasma membranes leading to virus entry into CC the host cell. Acts as a functional inhibitor of gH and maintains gH in CC an inhibited form. Upon binding to host integrins, gL dissociates from CC gH leading to activation of the viral fusion glycoproteins gB and gH. CC {ECO:0000256|HAMAP-Rule:MF_04036}. CC -!- SUBUNIT: Interacts with glycoprotein H (gH); this interaction is CC necessary for the correct processing and cell surface expression of gH. CC {ECO:0000256|HAMAP-Rule:MF_04036}. CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000256|HAMAP- CC Rule:MF_04036}; Peripheral membrane protein {ECO:0000256|HAMAP- CC Rule:MF_04036}; Extracellular side {ECO:0000256|HAMAP-Rule:MF_04036}. CC Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04036}; Peripheral CC membrane protein {ECO:0000256|HAMAP-Rule:MF_04036}; Extracellular side CC {ECO:0000256|HAMAP-Rule:MF_04036}. Host Golgi apparatus, host trans- CC Golgi network {ECO:0000256|HAMAP-Rule:MF_04036}. Note=gL associates CC with the extravirion surface through its binding to gH. During virion CC morphogenesis, this protein probably accumulates in the host trans- CC Golgi where secondary envelopment occurs. {ECO:0000256|HAMAP- CC Rule:MF_04036}. CC -!- SIMILARITY: Belongs to the herpesviridae glycoprotein L family. CC {ECO:0000256|HAMAP-Rule:MF_04036}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MZ822422; UEH20658.1; -; Genomic_DNA. DR Proteomes; UP001142623; Segment. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR HAMAP; MF_04036; HSV_GL_betahv; 1. DR InterPro; IPR002689; Cytomegalo_gL. DR Pfam; PF01801; Cytomega_gL; 1. PE 3: Inferred from homology; KW Fusion of virus membrane with host cell membrane {ECO:0000256|HAMAP- KW Rule:MF_04036}; KW Fusion of virus membrane with host membrane {ECO:0000256|HAMAP- KW Rule:MF_04036}; Glycoprotein {ECO:0000256|HAMAP-Rule:MF_04036}; KW Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04036}; KW Host Golgi apparatus {ECO:0000256|HAMAP-Rule:MF_04036}; KW Host membrane {ECO:0000256|HAMAP-Rule:MF_04036}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_04036}; KW Viral envelope protein {ECO:0000256|HAMAP-Rule:MF_04036, KW ECO:0000313|EMBL:UEH20658.1}; KW Viral penetration into host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04036}; KW Virion {ECO:0000256|ARBA:ARBA00022844, ECO:0000256|HAMAP-Rule:MF_04036}; KW Virus entry into host cell {ECO:0000256|HAMAP-Rule:MF_04036}. SQ SEQUENCE 301 AA; 34545 MW; 5EF62E73364CD0C3 CRC64; MIINVNLMSG LGYSIQKMDN TIATIVIGTL RLGEYVTIFT NMFIILLLVS PNKVCALYPY VSSSCYNSTL TCLNGGNILF TGMPQYSSNY SKLIRYDYSP NIMSSGYPID DKVYNTLSLF YKNEEDIRTF LSLRKDNNGT WEKSFIGVPE LKTVHEEEKT YVFCDKAYAT FFCSPYTKNC DERVNLNELP YVDSIFTEHV VELVFHGRPK VEIEVKILLY NPVTLAHKIV TIPLFTPALL DVTFNILYRT LYRNPDSHAL LRTFKAFFVE NVGEPYRGPR NDRFVRVWQG DGFERMGGSV L //