ID A0A9Q5HQF5_SANBA Unreviewed; 806 AA. AC A0A9Q5HQF5; DT 13-SEP-2023, integrated into UniProtKB/TrEMBL. DT 13-SEP-2023, sequence version 1. DT 02-OCT-2024, entry version 6. DE RecName: Full=ATP-dependent DNA helicase CHL1 {ECO:0000256|ARBA:ARBA00017386}; DE EC=5.6.2.3 {ECO:0000256|ARBA:ARBA00044969}; DE AltName: Full=ATP-dependent DNA helicase chl1 {ECO:0000256|ARBA:ARBA00016387}; DE AltName: Full=Chromosome loss protein 1 {ECO:0000256|ARBA:ARBA00029709}; DE AltName: Full=DNA 5'-3' helicase CHL1 {ECO:0000256|ARBA:ARBA00044998, ECO:0000256|ARBA:ARBA00045008}; GN ORFNames=A7U60_g8739 {ECO:0000313|EMBL:OCB84068.1}; OS Sanghuangporus baumii (Phellinus baumii). OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes; OC Hymenochaetales; Hymenochaetaceae; Sanghuangporus. OX NCBI_TaxID=108892 {ECO:0000313|EMBL:OCB84068.1, ECO:0000313|Proteomes:UP000757232}; RN [1] {ECO:0000313|EMBL:OCB84068.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=821 {ECO:0000313|EMBL:OCB84068.1}; RA Zhu H., Lin W.; RT "Draft Genome sequence of the fungus Inonotus baumii."; RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.3; CC Evidence={ECO:0000256|ARBA:ARBA00044904}; CC -!- CATALYTIC ACTIVITY: CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA at the CC replication fork by translocating in the 5'-3' direction. This CC creates two antiparallel DNA single strands (ssDNA). The leading CC ssDNA polymer is the template for DNA polymerase III holoenzyme which CC synthesizes a continuous strand.; EC=5.6.2.3; CC Evidence={ECO:0000256|ARBA:ARBA00044875}; CC -!- COFACTOR: CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; CC Evidence={ECO:0000256|ARBA:ARBA00001966}; CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily. CC DDX11/CHL1 sub-subfamily. {ECO:0000256|ARBA:ARBA00008435}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:OCB84068.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LNZH02000216; OCB84068.1; -; Genomic_DNA. DR Proteomes; UP000757232; Unassembled WGS sequence. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro. DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro. DR GO; GO:0034085; P:establishment of sister chromatid cohesion; IEA:TreeGrafter. DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro. DR CDD; cd18788; SF2_C_XPD; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR InterPro; IPR006555; ATP-dep_Helicase_C. DR InterPro; IPR045028; DinG/Rad3-like. DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3. DR InterPro; IPR006554; Helicase-like_DEXD_c2. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR010614; RAD3-like_helicase_DEAD. DR InterPro; IPR013020; Rad3/Chl1-like. DR NCBIfam; TIGR00604; rad3; 1. DR PANTHER; PTHR11472:SF41; ATP-DEPENDENT DNA HELICASE DDX11-RELATED; 1. DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1. DR Pfam; PF06733; DEAD_2; 1. DR Pfam; PF13307; Helicase_C_2; 1. DR SMART; SM00488; DEXDc2; 1. DR SMART; SM00491; HELICc2; 1. DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306}; KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:OCB84068.1}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Iron {ECO:0000256|ARBA:ARBA00023004}; KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014}; KW Isomerase {ECO:0000256|ARBA:ARBA00023235}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000757232}. FT DOMAIN 18..366 FT /note="Helicase ATP-binding" FT /evidence="ECO:0000259|PROSITE:PS51193" FT REGION 77..137 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 123..137 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 806 AA; 91324 MW; 35CA53AF4EED344F CRC64; MYIVYSGKMD GVKLSVPEQF RAFPFEQPYP IQKDFMRHVY SAIENHPEWV IVQTLERLKN EIETEELDLQ QYLADLREKE ESSRREHARV TKRPRICSPR GRKHNDPDDE SLLPDSESSD AQEGLIPPLS NDRTNRLLPS PTKIFFASRT HSQLSQVIRE LLALKPIPGV PDGLEEDSID PCHLASRPPR FPRSVSLASR NHLCINEQLR TRTVDLDEGC RQLLSGRREE RCPYLPPLGE EHRLDDFRDR ILASPKDIED LVIAGKDMKL CPYFGSRSAI ASAELVTLPY NLLLHEQSRK ALDINVQDQI VIIDEAHNLI DALLQLHTIE LSVSMLQAAI EQLTAYLSRF RTRLNSTNSV QLKRLILFLL ALHQFVESRS AAHNSVTSVS EFVESLGNKV NGINLHELQS YLTTSKVDIH AMTQGVASDT INTQIARKVS RYSEKRQYID KEDNSDVRGA SLLPLHTVEA FISKLTNHIE DGVITVAENQ FVSRGKTIKY QHLNPATYFE CIARSARSVI LAGGTMSPVS DMALQLFPNI AREQLTVFSC GHVIPRANLL CLVLGTGPRG RDLEFRFKDR EDKSLNQKID DLGQCLFNLA SVCPNGAVVF FPSYAFLDKV KRVWNTNGLL SRIRQKKQLF YEPHANAEVD DILQQYALAC NETFRTSRGA MLFAVVGAKL SEGLNFADEL ARAVVLVGIP YPNIASPELK ERMKYMRKHK QTTSDKEVDP GNELYENLAM RAVNQSIGRA IRHQNDWSTL ILVDKRYSSQ KVQAKLPGWI CQDIAVPESF GQAMKSLGEF YRSKRP //