ID   A0A9Q5FB47_RHOHA        Unreviewed;       184 AA.
AC   A0A9Q5FB47;
DT   13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 1.
DT   27-MAR-2024, entry version 4.
DE   RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE            EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
GN   ORFNames=A6I88_21360 {ECO:0000313|EMBL:ORL17704.1}, GS441_14335
GN   {ECO:0000313|EMBL:MBM4566578.1}, GS882_14970
GN   {ECO:0000313|EMBL:NKT79407.1}, GTA28_08750
GN   {ECO:0000313|EMBL:NKZ76958.1}, MWT96_14310
GN   {ECO:0000313|EMBL:UPH39694.1};
OS   Rhodococcus hoagii (Corynebacterium equii).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Prescottella.
OX   NCBI_TaxID=43767 {ECO:0000313|EMBL:NKZ76958.1, ECO:0000313|Proteomes:UP000624896};
RN   [1] {ECO:0000313|EMBL:ORL17704.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PAM2287 {ECO:0000313|EMBL:ORL17704.1};
RX   PubMed=27638249; DOI=.1093/gbe/evw222;
RA   Anastasi E., MacArthur I., Scortti M., Alvarez S., Giguere S.,
RA   Vazquez-Boland J.A.;
RT   "Pangenome and Phylogenomic Analysis of the Pathogenic Actinobacterium
RT   Rhodococcus equi.";
RL   Genome Biol. Evol. 8:3140-3148(2016).
RN   [2] {ECO:0000313|EMBL:NKZ76958.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Lh_123_1 {ECO:0000313|EMBL:NKZ76958.1};
RA   Huber L., Giguere S., Cohen N.D., Hart K.A., Slovis N., Greiter M.,
RA   Alvarez-Narvaez S.;
RT   "Prevalence and genetic variability between two genotypes of resistant
RT   Rhodococcus equi present in the environment and clinical isolates from
RT   foals in central Kentucky.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:MBM4566578.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Lh_17 {ECO:0000313|EMBL:MBM4566578.1};
RA   Alvarez-Narvaez S., Huber L., Cohen N.D., Slovis N., Greiter M.,
RA   Giguere S., Hart K.;
RT   "Spread of Macrolides and rifampicin resistant Rhodococcus equi in clinical
RT   isolates in the USA.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:NKT79407.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Lh_116_1 {ECO:0000313|EMBL:NKT79407.1};
RX   PubMed=32291839;
RA   Huber L., Giguere S., Slovis N.M., Alvarez-Narvaez S., Hart K.A.,
RA   Greiter M., Morris E.R.A., Cohen N.D.;
RT   "The novel and transferable erm(51) gene confers Macrolides, Lincosamides,
RT   and Streptogramins B (MLSB) resistance to clonal Rhodococcus equi in the
RT   environment.";
RL   Environ. Microbiol. 0:0-0(2020).
RN   [5] {ECO:0000313|EMBL:UPH39694.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PAM2287 {ECO:0000313|EMBL:UPH39694.1};
RA   Alvarez Narvaez S., Giguere S., Slovis N., Vazquez-Boland J.A.;
RT   "Complete genome sequences of two representative isolates of multidrug-
RT   resistant Rhodococcus equi clone 2287.";
RL   Submitted (APR-2022) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC   -!- SIMILARITY: Belongs to the RNase H family.
CC       {ECO:0000256|ARBA:ARBA00005300}.
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DR   EMBL; WUXR01000006; MBM4566578.1; -; Genomic_DNA.
DR   EMBL; WVBC01000030; NKT79407.1; -; Genomic_DNA.
DR   EMBL; WVDM01000001; NKZ76958.1; -; Genomic_DNA.
DR   EMBL; LWTV01000014; ORL17704.1; -; Genomic_DNA.
DR   EMBL; CP095477; UPH39694.1; -; Genomic_DNA.
DR   RefSeq; WP_013417446.1; NZ_MVDV01000042.1.
DR   Proteomes; UP000193670; Chromosome.
DR   Proteomes; UP000603463; Unassembled WGS sequence.
DR   Proteomes; UP000624896; Unassembled WGS sequence.
DR   Proteomes; UP000808906; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR   CDD; cd09278; RNase_HI_prokaryote_like; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR022892; RNaseHI.
DR   PANTHER; PTHR10642; RIBONUCLEASE H1; 1.
DR   PANTHER; PTHR10642:SF26; RIBONUCLEASE H1; 1.
DR   Pfam; PF00075; RNase_H; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
PE   3: Inferred from homology;
FT   DOMAIN          1..139
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
FT   REGION          144..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   184 AA;  19602 MW;  53996458D9152596 CRC64;
     MIIVSTDGSC LKNPGGAIGW AWVDHEGPSR SGGAVSGTNQ IAELWALVEA IVAHPGPEPL
     LIESDSQYAI KCASEWLPGW KRKGWKTASG GPVKNLELVQ DIDRAITERS GPVRFRWVRG
     HVGNHFNEIA DKLAGEAARA VASTPEKARP WAGLGPREVP PRPVAAVTPA AAPVRAPEPE
     LTLF
//