ID A0A9Q5FB47_RHOHA Unreviewed; 184 AA. AC A0A9Q5FB47; DT 13-SEP-2023, integrated into UniProtKB/TrEMBL. DT 13-SEP-2023, sequence version 1. DT 24-JAN-2024, entry version 3. DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180}; DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180}; GN ORFNames=A6I88_21360 {ECO:0000313|EMBL:ORL17704.1}, B0F69_04055 GN {ECO:0000313|EMBL:MBP0095838.1}, B0F76_11985 GN {ECO:0000313|EMBL:MBP0082667.1}, GS441_14335 GN {ECO:0000313|EMBL:MBM4566578.1}, GS505_24205 GN {ECO:0000313|EMBL:NKS28709.1}, GS551_07265 GN {ECO:0000313|EMBL:MBM4714002.1}, GS882_14970 GN {ECO:0000313|EMBL:NKT79407.1}, GS947_10540 GN {ECO:0000313|EMBL:NKW42039.1}, GTA28_08750 GN {ECO:0000313|EMBL:NKZ76958.1}, MWT96_14310 GN {ECO:0000313|EMBL:UPH39694.1}; OS Rhodococcus hoagii (Corynebacterium equii). OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae; OC Prescottella. OX NCBI_TaxID=43767 {ECO:0000313|EMBL:NKZ76958.1, ECO:0000313|Proteomes:UP000624896}; RN [1] {ECO:0000313|EMBL:ORL17704.1, ECO:0000313|Proteomes:UP000193670} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PAM2287 {ECO:0000313|EMBL:ORL17704.1, RC ECO:0000313|Proteomes:UP000193670}; RX PubMed=27638249; DOI=.1093/gbe/evw222; RA Anastasi E., MacArthur I., Scortti M., Alvarez S., Giguere S., RA Vazquez-Boland J.A.; RT "Pangenome and Phylogenomic Analysis of the Pathogenic Actinobacterium RT Rhodococcus equi."; RL Genome Biol. Evol. 8:3140-3148(2016). RN [2] {ECO:0000313|EMBL:MBP0082667.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PAM2281 {ECO:0000313|EMBL:MBP0095838.1}, and PAM2284 RC {ECO:0000313|EMBL:MBP0082667.1}; RX PubMed=31615959; RA Alvarez-Narvaez S., Giguere S., Anastasi E., Hearn J., Scortti M., RA Vazquez-Boland J.A.; RT "Clonal Confinement of a Highly Mobile Resistance Element Driven by RT Combination Therapy in Rhodococcus equi."; RL MBio 10:e02260-e02219(2019). RN [3] {ECO:0000313|EMBL:NKZ76958.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Lh_123_1 {ECO:0000313|EMBL:NKZ76958.1}; RA Huber L., Giguere S., Cohen N.D., Hart K.A., Slovis N., Greiter M., RA Alvarez-Narvaez S.; RT "Prevalence and genetic variability between two genotypes of resistant RT Rhodococcus equi present in the environment and clinical isolates from RT foals in central Kentucky."; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:MBM4566578.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Lh_17 {ECO:0000313|EMBL:MBM4566578.1}, and Lh_5 RC {ECO:0000313|EMBL:MBM4714002.1}; RA Alvarez-Narvaez S., Huber L., Cohen N.D., Slovis N., Greiter M., RA Giguere S., Hart K.; RT "Spread of Macrolides and rifampicin resistant Rhodococcus equi in clinical RT isolates in the USA."; RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:NKS28709.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Lh_116_1 {ECO:0000313|EMBL:NKT79407.1}, Lh_141_1 RC {ECO:0000313|EMBL:NKS28709.1}, and Lh_16_1 RC {ECO:0000313|EMBL:NKW42039.1}; RX PubMed=32291839; RA Huber L., Giguere S., Slovis N.M., Alvarez-Narvaez S., Hart K.A., RA Greiter M., Morris E.R.A., Cohen N.D.; RT "The novel and transferable erm(51) gene confers Macrolides, Lincosamides, RT and Streptogramins B (MLSB) resistance to clonal Rhodococcus equi in the RT environment."; RL Environ. Microbiol. 0:0-0(2020). RN [6] {ECO:0000313|EMBL:UPH39694.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=PAM2287 {ECO:0000313|EMBL:UPH39694.1}; RA Alvarez Narvaez S., Giguere S., Slovis N., Vazquez-Boland J.A.; RT "Complete genome sequences of two representative isolates of multidrug- RT resistant Rhodococcus equi clone 2287."; RL Submitted (APR-2022) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; CC Evidence={ECO:0000256|ARBA:ARBA00000077}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|ARBA:ARBA00001946}; CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}. CC -!- SIMILARITY: Belongs to the RNase H family. CC {ECO:0000256|ARBA:ARBA00005300}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; WUXR01000006; MBM4566578.1; -; Genomic_DNA. DR EMBL; WUYC01000001; MBM4714002.1; -; Genomic_DNA. DR EMBL; MULZ01000006; MBP0082667.1; -; Genomic_DNA. DR EMBL; MULT01000001; MBP0095838.1; -; Genomic_DNA. DR EMBL; WUYZ01000049; NKS28709.1; -; Genomic_DNA. DR EMBL; WVBC01000030; NKT79407.1; -; Genomic_DNA. DR EMBL; WVDC01000004; NKW42039.1; -; Genomic_DNA. DR EMBL; WVDM01000001; NKZ76958.1; -; Genomic_DNA. DR EMBL; LWTV01000014; ORL17704.1; -; Genomic_DNA. DR EMBL; CP095477; UPH39694.1; -; Genomic_DNA. DR RefSeq; WP_013417446.1; NZ_MVDV01000042.1. DR Proteomes; UP000193670; Chromosome. DR Proteomes; UP000193670; Unassembled WGS sequence. DR Proteomes; UP000603463; Unassembled WGS sequence. DR Proteomes; UP000605618; Unassembled WGS sequence. DR Proteomes; UP000608063; Unassembled WGS sequence. DR Proteomes; UP000624896; Unassembled WGS sequence. DR Proteomes; UP000706122; Unassembled WGS sequence. DR Proteomes; UP000715149; Unassembled WGS sequence. DR Proteomes; UP000808906; Unassembled WGS sequence. DR Proteomes; UP000810762; Unassembled WGS sequence. DR CDD; cd09278; RNase_HI_prokaryote_like; 1. DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1. DR InterPro; IPR012337; RNaseH-like_sf. DR InterPro; IPR002156; RNaseH_domain. DR InterPro; IPR036397; RNaseH_sf. DR InterPro; IPR022892; RNaseHI. DR PANTHER; PTHR10642; RIBONUCLEASE H1; 1. DR PANTHER; PTHR10642:SF26; RIBONUCLEASE H1; 1. DR Pfam; PF00075; RNase_H; 1. DR SUPFAM; SSF53098; Ribonuclease H-like; 1. DR PROSITE; PS50879; RNASE_H_1; 1. PE 3: Inferred from homology; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}. FT DOMAIN 1..139 FT /note="RNase H type-1" FT /evidence="ECO:0000259|PROSITE:PS50879" FT REGION 144..163 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 184 AA; 19602 MW; 53996458D9152596 CRC64; MIIVSTDGSC LKNPGGAIGW AWVDHEGPSR SGGAVSGTNQ IAELWALVEA IVAHPGPEPL LIESDSQYAI KCASEWLPGW KRKGWKTASG GPVKNLELVQ DIDRAITERS GPVRFRWVRG HVGNHFNEIA DKLAGEAARA VASTPEKARP WAGLGPREVP PRPVAAVTPA AAPVRAPEPE LTLF //