ID A0A9N8V218_9GLOM Unreviewed; 626 AA.
AC A0A9N8V218;
DT 13-SEP-2023, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 1.
DT 08-NOV-2023, entry version 2.
DE RecName: Full=Mitochondrial distribution and morphology protein 10 {ECO:0000256|HAMAP-Rule:MF_03102};
DE AltName: Full=Mitochondrial inheritance component MDM10 {ECO:0000256|HAMAP-Rule:MF_03102};
GN Name=MDM10 {ECO:0000256|HAMAP-Rule:MF_03102};
GN ORFNames=AGERDE_LOCUS249 {ECO:0000313|EMBL:CAG8433833.1};
OS Ambispora gerdemannii.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Glomeromycotina;
OC Glomeromycetes; Archaeosporales; Ambisporaceae; Ambispora.
OX NCBI_TaxID=144530 {ECO:0000313|EMBL:CAG8433833.1, ECO:0000313|Proteomes:UP000789831};
RN [1] {ECO:0000313|EMBL:CAG8433833.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MT106 {ECO:0000313|EMBL:CAG8433833.1};
RA Kallberg Y., Tangrot J., Rosling A.;
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the ERMES/MDM complex, which serves as a
CC molecular tether to connect the endoplasmic reticulum and mitochondria.
CC Components of this complex are involved in the control of mitochondrial
CC shape and protein biogenesis and may function in phospholipid exchange.
CC MDM10 is involved in the late assembly steps of the general translocase
CC of the mitochondrial outer membrane (TOM complex). Functions in the
CC TOM40-specific route of the assembly of outer membrane beta-barrel
CC proteins, including the association of TOM40 with the receptor TOM22
CC and small TOM proteins. Can associate with the SAM(core) complex as
CC well as the MDM12-MMM1 complex, both involved in late steps of the
CC major beta-barrel assembly pathway, that is responsible for biogenesis
CC of all outer membrane beta-barrel proteins. May act as a switch that
CC shuttles between both complexes and channels precursor proteins into
CC the TOM40-specific pathway. Plays a role in mitochondrial morphology
CC and in the inheritance of mitochondria. {ECO:0000256|HAMAP-
CC Rule:MF_03102}.
CC -!- SUBUNIT: Component of the ER-mitochondria encounter structure (ERMES)
CC or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates
CC with the mitochondrial outer membrane sorting assembly machinery
CC SAM(core) complex. {ECO:0000256|HAMAP-Rule:MF_03102}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000256|HAMAP-
CC Rule:MF_03102}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_03102}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Note=The
CC ERMES/MDM complex localizes to a few discrete foci (around 10 per
CC single cell), that represent mitochondria-endoplasmic reticulum
CC junctions. These foci are often found next to mtDNA nucleoids.
CC {ECO:0000256|HAMAP-Rule:MF_03102}.
CC -!- DOMAIN: Lacks alpha-helical transmembrane segments, suggesting that it
CC resides in the membrane via beta-sheet conformations similar to those
CC predicted for other outer membrane proteins and porin.
CC {ECO:0000256|HAMAP-Rule:MF_03102}.
CC -!- SIMILARITY: Belongs to the MDM10 family. {ECO:0000256|HAMAP-
CC Rule:MF_03102}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAG8433833.1}.
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DR EMBL; CAJVPL010000012; CAG8433833.1; -; Genomic_DNA.
DR Proteomes; UP000789831; Unassembled WGS sequence.
DR Gene3D; 1.20.1250.40; -; 1.
DR HAMAP; MF_03102; Mdm10; 1.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR027539; Mdm10.
DR InterPro; IPR006590; RNA_pol_Rpb4/RPC9_core.
DR InterPro; IPR005574; Rpb4/RPC9.
DR InterPro; IPR038324; Rpb4/RPC9_sf.
DR PANTHER; PTHR28035; MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10; 1.
DR PANTHER; PTHR28035:SF1; MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10; 1.
DR Pfam; PF12519; MDM10; 1.
DR Pfam; PF03874; RNA_pol_Rpb4; 1.
DR SMART; SM00657; RPOL4c; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Membrane {ECO:0000256|HAMAP-Rule:MF_03102};
KW Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03102};
KW Mitochondrion outer membrane {ECO:0000256|HAMAP-Rule:MF_03102};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_03102};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452,
KW ECO:0000256|HAMAP-Rule:MF_03102}.
FT DOMAIN 58..193
FT /note="RNA polymerase Rpb4/RPC9 core"
FT /evidence="ECO:0000259|SMART:SM00657"
FT REGION 453..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 626 AA; 71413 MW; 0829D0D1236115C0 CRC64;
MLIIILSKRV LTTGGHFTLI VFQRSIFRIV ENIIFVANKP DDEIQGALCV HVDKSEESEK
LRSLKWSALL SNHEVLQLLE EMREKQREQD RLNPKNTKHA ENFQTIQFEV IEYLKSDQSP
VDSQSATQIQ SLLDGLKEYP LTKIEKLQII NMRPTSIIEL HVLIEEPEDR DLMGKFPEIC
ELVKLHLPRK DKNHSSGVDN NIEMVLQQQN IEDNDIDNIG FHHSVEFASS SNSNNIINSL
GNMHDFMEFC LRQYFKTTGW NENNQYSNLC AASRAILDFK TPFGFTFTLS KMPTPLFKSS
YCMNALPTLS GSIGYLFTSR PLLVDPSVRV PFEEVVDRFN IYYSPQNEQQ NLLENDDQEN
RVKIKDYLLF ARMYIPTTRL EALYSKRFSP NLQCVVTGIS DLKYRAASHL TAELHYDAEK
WCTEVSFSTE GALFGIKGLY NFTGDIEKDE LEDEKKSTSI VEPETPTPHF LDRSKIDSND
YDNENVEEEV NGLKGQWSVG AEVYYGARER SGGVSTGIRY RTLPQHLNQS PLTVTYLFNP
IMGHMTAAFA AQVSDDLALC PRFYFNIYSY EKVLGVVKAT IGTSKGVCLL WEGRYGRSLF
SMGVVADLTS HSSPIRSVGL ELQYFA
//