ID A0A9L0RTE4_HORSE Unreviewed; 184 AA. AC A0A9L0RTE4; DT 13-SEP-2023, integrated into UniProtKB/TrEMBL. DT 13-SEP-2023, sequence version 1. DT 24-JUL-2024, entry version 6. DE SubName: Full=Platelet derived growth factor C {ECO:0000313|Ensembl:ENSECAP00000065976.1}; GN Name=PDGFC {ECO:0000313|Ensembl:ENSECAP00000065976.1, GN ECO:0000313|VGNC:VGNC:21259}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000065976.1, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000065976.1, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000065976.1, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T., RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000065976.1} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000065976.1}; RG Ensembl; RL Submitted (APR-2024) to UniProtKB. CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family. CC {ECO:0000256|ARBA:ARBA00006686, ECO:0000256|RuleBase:RU003818}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSECAT00000097006.1; ENSECAP00000065976.1; ENSECAG00000019512.3. DR VGNC; VGNC:21259; PDGFC. DR GeneTree; ENSGT00940000158645; -. DR Proteomes; UP000002281; Chromosome 2. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW. DR CDD; cd00135; PDGF; 1. DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR000072; PDGF/VEGF_dom. DR PANTHER; PTHR11633; PLATELET-DERIVED GROWTH FACTOR; 1. DR PANTHER; PTHR11633:SF5; PLATELET-DERIVED GROWTH FACTOR C; 1. DR Pfam; PF00341; PDGF; 1. DR SMART; SM00141; PDGF; 1. DR SUPFAM; SSF57501; Cystine-knot cytokines; 1. DR PROSITE; PS50278; PDGF_2; 1. PE 3: Inferred from homology; KW Growth factor {ECO:0000256|RuleBase:RU003818}; KW Mitogen {ECO:0000256|ARBA:ARBA00023246}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}. FT DOMAIN 89..181 FT /note="Platelet-derived growth factor (PDGF) family FT profile" FT /evidence="ECO:0000259|PROSITE:PS50278" SQ SEQUENCE 184 AA; 20863 MW; 1E0BCC49C21973BE CRC64; MLLKQFTEAV SPSALPPSAL PLDLLNNAVT AFSTLEDLIR YLEPDRWQLD LEDLYRPTWQ LLGKAFVFGR KSRVVDLNLL KEEVRLYSCT PRNFSVSIRE ELKRTDTIFW PGCLLVKRCG GNCACCLHNC NECQCVPSKV TKKYHEVLQL RPKNGVRGLH KSLTDVALEH HEECDCVCRG NSGG //