ID A0A9D4YLA5_PEA Unreviewed; 449 AA. AC A0A9D4YLA5; DT 03-MAY-2023, integrated into UniProtKB/TrEMBL. DT 03-MAY-2023, sequence version 1. DT 02-OCT-2024, entry version 9. DE RecName: Full=DNA replication licensing factor MCM7 {ECO:0000256|RuleBase:RU365012}; DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU365012}; GN Name=MCM7 {ECO:0000256|RuleBase:RU365012}; GN ORFNames=KIW84_024884 {ECO:0000313|EMBL:KAI5439275.1}; OS Pisum sativum (Garden pea) (Lathyrus oleraceus). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade; OC NPAAA clade; Hologalegina; IRL clade; Fabeae; Pisum. OX NCBI_TaxID=3888 {ECO:0000313|EMBL:KAI5439275.1, ECO:0000313|Proteomes:UP001058974}; RN [1] {ECO:0000313|EMBL:KAI5439275.1, ECO:0000313|Proteomes:UP001058974} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Zhongwan 6 {ECO:0000313|EMBL:KAI5439275.1, RC ECO:0000313|Proteomes:UP001058974}; RX PubMed=36138232; DOI=10.1038/s41588-022-01172-2; RA Yang T., Liu R., Luo Y., Hu S., Wang D., Wang C., Pandey M.K., Ge S., RA Xu Q., Li N., Li G., Huang Y., Saxena R.K., Ji Y., Li M., Yan X., He Y., RA Liu Y., Wang X., Xiang C., Varshney R.K., Ding H., Gao S., Zong X.; RT "Improved pea reference genome and pan-genome highlight genomic features RT and evolutionary characteristics."; RL Nat. Genet. 54:1553-1563(2022). CC -!- FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which CC is the replicative helicase essential for 'once per cell cycle' DNA CC replication initiation and elongation in eukaryotic cells. The active CC ATPase sites in the MCM2-7 ring are formed through the interaction CC surfaces of two neighboring subunits such that a critical structure of CC a conserved arginine finger motif is provided in trans relative to the CC ATP-binding site of the Walker A box of the adjacent subunit. The six CC ATPase active sites, however, are likely to contribute differentially CC to the complex helicase activity. {ECO:0000256|RuleBase:RU365012}. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12; CC Evidence={ECO:0000256|ARBA:ARBA00001665, CC ECO:0000256|RuleBase:RU365012}; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365012}. CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU365012}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:KAI5439275.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JAMSHJ010000002; KAI5439275.1; -; Genomic_DNA. DR Proteomes; UP001058974; Chromosome 2. DR GO; GO:0042555; C:MCM complex; IEA:InterPro. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro. DR Gene3D; 2.20.28.10; -; 1. DR Gene3D; 3.30.70.330; -; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR InterPro; IPR031327; MCM. DR InterPro; IPR008050; MCM7. DR InterPro; IPR001208; MCM_dom. DR InterPro; IPR033762; MCM_OB. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR019002; Ribosome_biogenesis_Nop16. DR InterPro; IPR000504; RRM_dom. DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1. DR PANTHER; PTHR11630:SF26; DNA REPLICATION LICENSING FACTOR MCM7; 1. DR Pfam; PF00493; MCM; 1. DR Pfam; PF17207; MCM_OB; 1. DR Pfam; PF09420; Nop16; 2. DR Pfam; PF00076; RRM_1; 1. DR PRINTS; PR01663; MCMPROTEIN7. DR SMART; SM00350; MCM; 1. DR SMART; SM00360; RRM; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1. DR PROSITE; PS50051; MCM_2; 1. DR PROSITE; PS50102; RRM; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU365012}; KW Cell cycle {ECO:0000256|RuleBase:RU365012}; KW DNA replication {ECO:0000256|RuleBase:RU365012}; KW DNA-binding {ECO:0000256|RuleBase:RU365012}; KW Helicase {ECO:0000256|RuleBase:RU365012}; KW Hydrolase {ECO:0000256|RuleBase:RU365012}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU365012}; Nucleus {ECO:0000256|RuleBase:RU365012}; KW Reference proteome {ECO:0000313|Proteomes:UP001058974}; KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}. FT DOMAIN 174..220 FT /note="RRM" FT /evidence="ECO:0000259|PROSITE:PS50102" FT DOMAIN 395..435 FT /note="MCM" FT /evidence="ECO:0000259|PROSITE:PS50051" FT REGION 83..116 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 96..114 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 449 AA; 51142 MW; A92421683D86D774 CRC64; MFKVFQLKYR PRRKYKNSRP KVRVGLPKKN PKVLKPAFTI PPKLLQSLAE DPKWDEKGSV TQNYNSFGVV NDPNSLTDNL QAPSVSDDPN DSGSDLEEDD LKSALGKRRR DGKSALPQPL TSIQRLYISR LVEKYGADFQ RMMMDIKLNP MQHSVATLEK LCMSYYIYKN KNPLIIFVGG LNPNVTDEDL RQTFSEYGEI TSVKIPVGKG CGFVQFANSK IITVKNYYVI TRCSDVKPLM QVAVYTCEDC GFEIYQEVTT RIFMPLFECP SRRCVMNKSK GNVILQLRAS KFLRFQEAKI QELAEHVPKG HIPRTMIVHL RGELTRKVAP GDVVELSGIF LPIPYVGFRA MRAGLVADTY LEAMSVSHFK KKYEEYELRG DEEEQIKRLA EDGDIYDKLA RSLAPEIFGH EDIKKALLLL LVGAPHRQLK DGMKVINFIL FEAHMFNGA //