ID A0A994J7U9_HUMAN Unreviewed; 800 AA. AC A0A994J7U9; DT 03-MAY-2023, integrated into UniProtKB/TrEMBL. DT 03-MAY-2023, sequence version 1. DT 27-MAR-2024, entry version 6. DE SubName: Full=Sarcolemma associated protein {ECO:0000313|Ensembl:ENSP00000516146.1}; GN Name=SLMAP {ECO:0000313|Ensembl:ENSP00000516146.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000516146.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000516146.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000516146.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC099777; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC114480; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; A0A994J7U9; -. DR Ensembl; ENST00000705630.1; ENSP00000516146.1; ENSG00000163681.17. DR HGNC; HGNC:16643; SLMAP. DR GeneTree; ENSGT00940000157660; -. DR Proteomes; UP000005640; Chromosome 3. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR CDD; cd21911; CC1_SLMAP; 1. DR CDD; cd22679; FHA_SLMAP; 1. DR Gene3D; 1.10.287.1490; -; 1. DR Gene3D; 2.60.200.20; -; 1. DR InterPro; IPR000253; FHA_dom. DR InterPro; IPR008984; SMAD_FHA_dom_sf. DR PANTHER; PTHR15715; CENTROSOMAL PROTEIN OF 170 KDA; 1. DR PANTHER; PTHR15715:SF26; COILED-COIL DOMAIN-CONTAINING PROTEIN 136; 1. DR Pfam; PF00498; FHA; 1. DR SMART; SM00240; FHA; 1. DR SUPFAM; SSF49879; SMAD/FHA domain; 1. DR PROSITE; PS50006; FHA_DOMAIN; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|EPD:A0A994J7U9, KW ECO:0007829|MaxQB:A0A994J7U9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 773..792 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 28..85 FT /note="FHA" FT /evidence="ECO:0000259|PROSITE:PS50006" FT REGION 453..495 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 172..199 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 233..387 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 496..582 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 612..770 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 453..481 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 800 AA; 91687 MW; ACFA0C62E45F96AE CRC64; MPSALAIFTC RPNSHPFQER HVYLDEPIKI GRSVARCRPA QNNATFDCKV LSRNHALVWF DHKTGKFYLQ DTKSSNGTFI NSQRLSRGSE ESPPCEILSG DIIQFGVDVT ENTRKVTHGC IVSTIKLFLP DGMEARLRSD VIHAPLPSPV DKVAANTPSM YSQELFQLSQ YLQEALHREQ MLEQKLATLQ RLLAITQEAS DTSWQALIDE DRLLSRLEVM GNQLQACSKN QTEDSLRKEL IALQEDKHNY ETTAKESLRR VLQEKIEVVR KLSEVERSLS NTEDECTHLK EMNERTQEEL RELANKYNGA VNEIKDLSDK LKVAEGKQEE IQQKGQAEKK ELQHKIDEME EKEQELQAKI EALQADNDFT NERLTALQVR LEHLQEKTLK ECSSLGIQVD DFLPKINGST EKEHLLSKSG GDCTFIHQFI ECQKKLIVEG HLTKAVEETK LSKENQTRAK ESDFSDTLSP SKEKSSDDTT DAQMDEQDLN EPLAKVSLLK DDLQGAQSEI EAKQEIQHLR KELIEAQELA RTSKQKCFEL QALLEEERKA YRNQVEESTK QIQVLQAQLQ RLHIDTENLR EEKDSEITST RDELLSARDE ILLLHQAAAK VASERDTDIA SLQEELKKVR AELERWRKAA SEYEKEITSL QNSFQLRCQQ CEDQQREEAT RLQGELEKLR KEWNALETEC HSLKRENVLL SSELQRQEKE LHNSQKQSLE LTSDLSILQM SRKELENQVG SLKEQHLRDS ADLKTLLSKA ENQAKDVQKE KPWPWMPMLA ALVAVTAIVL YVPGLARASP //