ID A0A994J558_HUMAN Unreviewed; 787 AA. AC A0A994J558; DT 03-MAY-2023, integrated into UniProtKB/TrEMBL. DT 03-MAY-2023, sequence version 1. DT 29-MAY-2024, entry version 7. DE SubName: Full=Sarcolemma associated protein {ECO:0000313|Ensembl:ENSP00000516145.1}; GN Name=SLMAP {ECO:0000313|Ensembl:ENSP00000516145.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000516145.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000516145.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000516145.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2024) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC099777; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC114480; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; A0A994J558; -. DR PeptideAtlas; A0A994J558; -. DR Ensembl; ENST00000705629.1; ENSP00000516145.1; ENSG00000163681.17. DR HGNC; HGNC:16643; SLMAP. DR GeneTree; ENSGT00940000157660; -. DR Proteomes; UP000005640; Chromosome 3. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:TreeGrafter. DR GO; GO:1900825; P:regulation of membrane depolarization during cardiac muscle cell action potential; IEA:TreeGrafter. DR CDD; cd21911; CC1_SLMAP; 1. DR CDD; cd22679; FHA_SLMAP; 1. DR Gene3D; 1.10.287.1490; -; 1. DR Gene3D; 2.60.200.20; -; 1. DR InterPro; IPR000253; FHA_dom. DR InterPro; IPR008984; SMAD_FHA_dom_sf. DR PANTHER; PTHR15715; CENTROSOMAL PROTEIN OF 170 KDA; 1. DR PANTHER; PTHR15715:SF22; SARCOLEMMAL MEMBRANE-ASSOCIATED PROTEIN; 1. DR Pfam; PF00498; FHA; 1. DR SMART; SM00240; FHA; 1. DR SUPFAM; SSF49879; SMAD/FHA domain; 1. DR PROSITE; PS50006; FHA_DOMAIN; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|EPD:A0A994J558, KW ECO:0007829|MaxQB:A0A994J558}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 760..779 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 28..85 FT /note="FHA" FT /evidence="ECO:0000259|PROSITE:PS50006" FT REGION 333..352 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 388..433 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 172..199 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 438..524 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 554..754 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 395..423 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 787 AA; 90438 MW; F602372DAF9357A8 CRC64; MPSALAIFTC RPNSHPFQER HVYLDEPIKI GRSVARCRPA QNNATFDCKV LSRNHALVWF DHKTGKFYLQ DTKSSNGTFI NSQRLSRGSE ESPPCEILSG DIIQFGVDVT ENTRKVTHGC IVSTIKLFLP DGMEARLRSD VIHAPLPSPV DKVAANTPSM YSQELFQLSQ YLQEALHREQ MLEQKLATLQ RLLAITQEAS DTSWQALIDE DRLLSRLEVM GNQLQACSKN QTEDSLRKEL IALQEDKHNY ETTAKESLRR VLQEKIEVVR KLSEVERSLS NTEDECTHLK EMNERTQEEL RELANKYNGA VNEIKDLSDK LKVAEGKQEE IQQKGQAEKK ELQHKIDEME EKEQELQAKI EALQADNDFT NERLTALQGI QVDDFLPKIN GSTEKENQTR AKESDFSDTL SPSKEKSSDD TTDAQMDEQD LNEPLAKVSL LKDDLQGAQS EIEAKQEIQH LRKELIEAQE LARTSKQKCF ELQALLEEER KAYRNQVEES TKQIQVLQAQ LQRLHIDTEN LREEKDSEIT STRDELLSAR DEILLLHQAA AKVASERDTD IASLQEELKK VRAELERWRK AASEYEKEIT SLQNSFQLRC QQCEDQQREE ATRLQGELEK LRKEWNALET ECHSLKRENV LLSSELQRQE KELHNSQKQS LELTSDLSIL QMSRKELENQ VGSLKEQHLR DSADLKTLLS KAENQAKDVQ KEYEKTQTVL SELKLKFEMT EQEKQSITDE LKQCKNNLKL LREKGNNKPW PWMPMLAALV AVTAIVLYVP GLARASP //