ID A0A976XJ52_CNIMO Unreviewed; 358 AA. AC A0A976XJ52; DT 22-FEB-2023, integrated into UniProtKB/TrEMBL. DT 22-FEB-2023, sequence version 1. DT 29-MAY-2024, entry version 8. DE SubName: Full=O-methyltransferase 1 {ECO:0000313|EMBL:UVB78653.1}; GN Name=OMT1 {ECO:0000313|EMBL:UVB78653.1}; OS Cnidium monnieri (Monnier's snowparsley) (Selinum monnieri). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC asterids; campanulids; Apiales; Apiaceae; Apioideae; apioid superclade; OC Selineae; Cnidium. OX NCBI_TaxID=94007 {ECO:0000313|EMBL:UVB78653.1}; RN [1] {ECO:0000313|EMBL:UVB78653.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=35930697; RA Zhang Y., Bai P., Zhuang Y., Liu T.; RT "Two O-Methyltransferases Mediate Multiple Methylation Steps in the RT Biosynthesis of Coumarins in Cnidium monnieri."; RL J. Nat. Prod. 0:0-0(2022). CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase CC superfamily. Cation-independent O-methyltransferase family. COMT CC subfamily. {ECO:0000256|ARBA:ARBA00034481}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; ON313741; UVB78653.1; -; mRNA. DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:TreeGrafter. DR GO; GO:0019438; P:aromatic compound biosynthetic process; IEA:TreeGrafter. DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW. DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR016461; COMT-like. DR InterPro; IPR001077; O_MeTrfase_dom. DR InterPro; IPR012967; Plant_MeTrfase_dimerisation. DR InterPro; IPR029063; SAM-dependent_MTases_sf. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1. DR PANTHER; PTHR11746:SF98; O-METHYLTRANSFERASE FAMILY PROTEIN; 1. DR Pfam; PF08100; Dimerisation; 1. DR Pfam; PF00891; Methyltransf_2; 1. DR PIRSF; PIRSF005739; O-mtase; 1. DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. PE 2: Evidence at transcript level; KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603}; KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}; KW Transferase {ECO:0000256|ARBA:ARBA00022603}. FT DOMAIN 35..78 FT /note="Plant methyltransferase dimerisation" FT /evidence="ECO:0000259|Pfam:PF08100" FT DOMAIN 129..337 FT /note="O-methyltransferase" FT /evidence="ECO:0000259|Pfam:PF00891" FT ACT_SITE 260 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1" SQ SEQUENCE 358 AA; 39398 MW; C6027291EDB24838 CRC64; MEGMTKNEAT HENEDTAQAQ VDIWRFVYGF AETAAVKCAV ELGIPDILEN HTEPMTLSQL SSALACRSTP LFRIMRFLMN IGLFKEKRTN QGSMGYVQTP MSRLLVKDGK NSLASMFLFV NGSVMTAPWN FLSAHVLDDR ASPFTYAHGM GSWKLAAGNP DFRKLIDDAM ACDTKMTVPA VLDGCPELFN GLSSVVNVGG GNGAAVRILV ERCPWIHGIN FDLPQVVSVA PVCEGIEHVG GDMFMSVPKA NAAFLKWVLH NWSDDECIKI LKNCREAIAE YGTSGKVIIV DAVIEGNGGD KPKNMGVLLD LIMLAQTDKG KERTAREWTF IFREAGFTRH TIKNIPFLTE ITVIEAYP //