ID   A0A974H0G7_XENLA        Unreviewed;       528 AA.
AC   A0A974H0G7;
DT   22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2023, sequence version 1.
DT   27-NOV-2024, entry version 9.
DE   RecName: Full=FAM83 N-terminal domain-containing protein {ECO:0000259|Pfam:PF07894};
GN   Name=fam83c.S {ECO:0000313|Xenbase:XB-GENE-6487655};
GN   ORFNames=XELAEV_18046009mg {ECO:0000313|EMBL:OCT59990.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:OCT59990.1, ECO:0000313|Proteomes:UP000694892};
RN   [1] {ECO:0000313|Proteomes:UP000694892}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J {ECO:0000313|Proteomes:UP000694892};
RX   PubMed=27762356; DOI=10.1038/nature19840;
RA   Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA   Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I.,
RA   Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O.,
RA   Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M.,
RA   Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I.,
RA   Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J.,
RA   Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y.,
RA   Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J.,
RA   Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V.,
RA   Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W.,
RA   Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA   Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J.,
RA   Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT   "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL   Nature 538:336-343(2016).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the FAM83 family.
CC       {ECO:0000256|ARBA:ARBA00006937}.
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DR   EMBL; CM004483; OCT59990.1; -; Genomic_DNA.
DR   RefSeq; XP_018093531.1; XM_018238042.1.
DR   GeneID; 108702528; -.
DR   KEGG; xla:108702528; -.
DR   AGR; Xenbase:XB-GENE-6487655; -.
DR   CTD; 108702528; -.
DR   Xenbase; XB-GENE-6487655; fam83c.S.
DR   OMA; DYMTSHV; -.
DR   Proteomes; UP000694892; Chromosome 9_10S.
DR   GO; GO:0019901; F:protein kinase binding; IEA:TreeGrafter.
DR   GO; GO:0007165; P:signal transduction; IEA:TreeGrafter.
DR   FunFam; 3.30.870.10:FF:000004; protein FAM83H isoform X2; 1.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 1.
DR   InterPro; IPR050944; FAM83.
DR   InterPro; IPR012461; FAM83_N.
DR   PANTHER; PTHR16181:SF28; PROTEIN FAM83B-RELATED; 1.
DR   PANTHER; PTHR16181; UNCHARACTERIZED; 1.
DR   Pfam; PF07894; FAM83; 1.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 1.
PE   3: Inferred from homology;
FT   DOMAIN          26..304
FT                   /note="FAM83 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07894"
FT   REGION          327..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          469..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..375
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..395
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   528 AA;  60193 MW;  997C80A7EE92A7A6 CRC64;
     MLNPEARRGV RMAGQLKNRV EELKNPWRQS SPLVFNYNET ARLATDALVE RGEKAYLHVL
     QEEKELPFLS SLDIDFICNN VAANEKSNHS IISDKDLDGT ISEDHCPSEL TSGTYFPFMS
     DFDAPDLELG WPEIPLTTKA KKTEVQVFFQ KHRSNEIKEL IRSHINMAKR VIAAVMDLFT
     DVDILCDLIE AASKRRVPVY LLLDEKNLEH FIDMYEKLGF NKTSFENMKI RTITGDTYCT
     KSGKKFSGQC MEKFLMTDCE HVFAGSYSFC WLSSHVHSNM LTYFKGNIVE EFDREFRCLY
     AESLEVDYFN NAENENRSFM QGVTRNRWTP LKTPPAPLPI FGHSTPSNSD SSSDSQSSVK
     TPPFSKNQAN TIIHEERVIG SNHISKKEND QSKPMVENLV ERRQSDPEPD MKNLQIMQKS
     PLSRSSPVLT DKNQLPPTPQ YIGRFGGLQS KALQSENKMT PRMKSDIALN KLPNGAGMDG
     RKDGEVLTNG KHDMPAINSK RMTLGHSKLE LITQYNNMTK KVFSRFEK
//