ID A0A930UQP1_9GAMM Unreviewed; 184 AA. AC A0A930UQP1; DT 22-FEB-2023, integrated into UniProtKB/TrEMBL. DT 22-FEB-2023, sequence version 1. DT 13-SEP-2023, entry version 4. DE RecName: Full=Threonylcarbamoyl-AMP synthase {ECO:0000256|HAMAP-Rule:MF_01852}; DE Short=TC-AMP synthase {ECO:0000256|HAMAP-Rule:MF_01852}; DE EC=2.7.7.87 {ECO:0000256|HAMAP-Rule:MF_01852}; DE AltName: Full=L-threonylcarbamoyladenylate synthase {ECO:0000256|HAMAP-Rule:MF_01852}; DE AltName: Full=t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC {ECO:0000256|HAMAP-Rule:MF_01852}; DE AltName: Full=tRNA threonylcarbamoyladenosine biosynthesis protein TsaC {ECO:0000256|HAMAP-Rule:MF_01852}; GN Name=tsaC {ECO:0000256|HAMAP-Rule:MF_01852}; GN ORFNames=ISN28_11490 {ECO:0000313|EMBL:MBF2760867.1}; OS Ectothiorhodospiraceae bacterium AqS1. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; OC Ectothiorhodospiraceae. OX NCBI_TaxID=1725326 {ECO:0000313|EMBL:MBF2760867.1, ECO:0000313|Proteomes:UP000606098}; RN [1] {ECO:0000313|EMBL:MBF2760867.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AqS1 {ECO:0000313|EMBL:MBF2760867.1}; RA Degnan B., Degnan S., Xiang X.; RT "An improved Amphimedon queenslandica hologenome assembly reveals how three RT proteobacterial symbionts can extend the metabolic phenotypic of their RT marine sponge host."; RL Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Required for the formation of a threonylcarbamoyl group on CC adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning CC with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) CC and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate CC intermediate, with the release of diphosphate. {ECO:0000256|HAMAP- CC Rule:MF_01852}. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L- CC threonylcarbamoyladenylate; Xref=Rhea:RHEA:36407, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, CC ChEBI:CHEBI:57926, ChEBI:CHEBI:73682; EC=2.7.7.87; CC Evidence={ECO:0000256|HAMAP-Rule:MF_01852}; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01852}. CC -!- SIMILARITY: Belongs to the SUA5 family. TsaC subfamily. CC {ECO:0000256|HAMAP-Rule:MF_01852}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:MBF2760867.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JADHEH010000087; MBF2760867.1; -; Genomic_DNA. DR Proteomes; UP000606098; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro. DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-UniRule. DR GO; GO:0002949; P:tRNA threonylcarbamoyladenosine modification; IEA:UniProtKB-UniRule. DR Gene3D; 3.90.870.10; DHBP synthase; 1. DR HAMAP; MF_01852; TsaC; 1. DR InterPro; IPR017945; DHBP_synth_RibB-like_a/b_dom. DR InterPro; IPR006070; Sua5-like_dom. DR InterPro; IPR023535; TC-AMP_synthase. DR PANTHER; PTHR17490; SUA5; 1. DR PANTHER; PTHR17490:SF18; THREONYLCARBAMOYL-AMP SYNTHASE; 1. DR Pfam; PF01300; Sua5_yciO_yrdC; 1. DR SUPFAM; SSF55821; YrdC/RibB; 1. DR PROSITE; PS51163; YRDC; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP- KW Rule:MF_01852}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01852}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_01852}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP- KW Rule:MF_01852}; Reference proteome {ECO:0000313|Proteomes:UP000606098}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP- KW Rule:MF_01852}; KW tRNA processing {ECO:0000256|ARBA:ARBA00022694, ECO:0000256|HAMAP- KW Rule:MF_01852}. FT DOMAIN 3..184 FT /note="YrdC-like" FT /evidence="ECO:0000259|PROSITE:PS51163" SQ SEQUENCE 184 AA; 20166 MW; A7A7DFD9727DFE31 CRC64; MGGWRYRRAI ETLRQGGIIA YPTEAVFGLG CDPLNRSAVA RIFAVKRRSL HKRCILIAAE IEQLAFFTDT SDPLFAEHAA RFWPGPVTLV VKAQRRVPPW LASEEGSIAL RVSDHLVPRA LCSAFGGALV STSANRSSRA PVREISKARL AFGTEVDCYV RGRVGGLDRP TRIIDIHSGS VLRA //