ID   A0A930UQP1_9GAMM        Unreviewed;       184 AA.
AC   A0A930UQP1;
DT   22-FEB-2023, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2023, sequence version 1.
DT   28-JUN-2023, entry version 3.
DE   RecName: Full=Threonylcarbamoyl-AMP synthase {ECO:0000256|HAMAP-Rule:MF_01852};
DE            Short=TC-AMP synthase {ECO:0000256|HAMAP-Rule:MF_01852};
DE            EC=2.7.7.87 {ECO:0000256|HAMAP-Rule:MF_01852};
DE   AltName: Full=L-threonylcarbamoyladenylate synthase {ECO:0000256|HAMAP-Rule:MF_01852};
DE   AltName: Full=t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC {ECO:0000256|HAMAP-Rule:MF_01852};
DE   AltName: Full=tRNA threonylcarbamoyladenosine biosynthesis protein TsaC {ECO:0000256|HAMAP-Rule:MF_01852};
GN   Name=tsaC {ECO:0000256|HAMAP-Rule:MF_01852};
GN   ORFNames=ISN28_11490 {ECO:0000313|EMBL:MBF2760867.1};
OS   Ectothiorhodospiraceae bacterium AqS1.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae.
OX   NCBI_TaxID=1725326 {ECO:0000313|EMBL:MBF2760867.1, ECO:0000313|Proteomes:UP000606098};
RN   [1] {ECO:0000313|EMBL:MBF2760867.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AqS1 {ECO:0000313|EMBL:MBF2760867.1};
RA   Degnan B., Degnan S., Xiang X.;
RT   "An improved Amphimedon queenslandica hologenome assembly reveals how three
RT   proteobacterial symbionts can extend the metabolic phenotypic of their
RT   marine sponge host.";
RL   Submitted (OCT-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the formation of a threonylcarbamoyl group on
CC       adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning
CC       with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2)
CC       and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate
CC       intermediate, with the release of diphosphate. {ECO:0000256|HAMAP-
CC       Rule:MF_01852}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-
CC         threonylcarbamoyladenylate; Xref=Rhea:RHEA:36407, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57926, ChEBI:CHEBI:73682; EC=2.7.7.87;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01852};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01852}.
CC   -!- SIMILARITY: Belongs to the SUA5 family. TsaC subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01852}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:MBF2760867.1}.
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DR   EMBL; JADHEH010000087; MBF2760867.1; -; Genomic_DNA.
DR   Proteomes; UP000606098; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0002949; P:tRNA threonylcarbamoyladenosine modification; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.870.10; DHBP synthase; 1.
DR   HAMAP; MF_01852; TsaC; 1.
DR   InterPro; IPR017945; DHBP_synth_RibB-like_a/b_dom.
DR   InterPro; IPR006070; Sua5-like_dom.
DR   InterPro; IPR023535; TC-AMP_synthase.
DR   PANTHER; PTHR17490; SUA5; 1.
DR   PANTHER; PTHR17490:SF18; THREONYLCARBAMOYL-AMP SYNTHASE; 1.
DR   Pfam; PF01300; Sua5_yciO_yrdC; 1.
DR   SUPFAM; SSF55821; YrdC/RibB; 1.
DR   PROSITE; PS51163; YRDC; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_01852};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01852};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_01852};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW   Rule:MF_01852}; Reference proteome {ECO:0000313|Proteomes:UP000606098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_01852};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694, ECO:0000256|HAMAP-
KW   Rule:MF_01852}.
FT   DOMAIN          3..184
FT                   /note="YrdC-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51163"
SQ   SEQUENCE   184 AA;  20166 MW;  A7A7DFD9727DFE31 CRC64;
     MGGWRYRRAI ETLRQGGIIA YPTEAVFGLG CDPLNRSAVA RIFAVKRRSL HKRCILIAAE
     IEQLAFFTDT SDPLFAEHAA RFWPGPVTLV VKAQRRVPPW LASEEGSIAL RVSDHLVPRA
     LCSAFGGALV STSANRSSRA PVREISKARL AFGTEVDCYV RGRVGGLDRP TRIIDIHSGS
     VLRA
//