ID A0A8P0SDL0_CANLF Unreviewed; 934 AA. AC A0A8P0SDL0; DT 28-JUN-2023, integrated into UniProtKB/TrEMBL. DT 28-JUN-2023, sequence version 1. DT 28-JUN-2023, entry version 1. DE SubName: Full=ADAM metallopeptidase with thrombospondin type 1 motif 5 {ECO:0000313|Ensembl:ENSCAFP00000012608.5}; GN Name=ADAMTS5 {ECO:0000313|Ensembl:ENSCAFP00000012608.5, GN ECO:0000313|VGNC:VGNC:37601}; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis. OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000012608.5, ECO:0000313|Proteomes:UP000002254}; RN [1] {ECO:0000313|Ensembl:ENSCAFP00000012608.5, ECO:0000313|Proteomes:UP000002254} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000012608.5}; RX PubMed=16341006; DOI=10.1038/nature04338; RG Broad Sequencing Platform; RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B., RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E., RA Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F., RA Smith D.R., deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W., RA Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S., RA Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A., RA Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P., RA Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A., RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P., RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P., RA Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B., RA Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A., RA Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M., RA Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., RA Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., RA Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S., RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C., RA Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G., RA Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N., RA Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A., RA Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A., RA Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M., RA Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., RA LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A., RA Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S., RA Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., RA Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., RA Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N., RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S., RA Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M., RA Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F., RA Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T., RA Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C., RA Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., RA Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D., RA Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H., RA Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J., RA Zembek L., Zimmer A., Lander E.S.; RT "Genome sequence, comparative analysis and haplotype structure of the RT domestic dog."; RL Nature 438:803-819(2005). RN [2] {ECO:0000313|Ensembl:ENSCAFP00000012608.5} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSCAFT00000013627.5; ENSCAFP00000012608.5; ENSCAFG00000024758.5. DR VGNC; VGNC:37601; ADAMTS5. DR GeneTree; ENSGT00940000159090; -. DR Proteomes; UP000002254; Chromosome 31. DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl. DR GO; GO:0008201; F:heparin binding; IEA:Ensembl. DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl. DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:Ensembl. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl. DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl. DR GO; GO:0003203; P:endocardial cushion morphogenesis; IEA:Ensembl. DR GO; GO:0022617; P:extracellular matrix disassembly; IEA:Ensembl. DR GO; GO:0007520; P:myoblast fusion; IEA:Ensembl. DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR GO; GO:0003184; P:pulmonary valve morphogenesis; IEA:Ensembl. DR CDD; cd04273; ZnMc_ADAMTS_like; 1. DR Gene3D; 2.60.120.830; -; 1. DR Gene3D; 3.40.1620.60; -; 2. DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1. DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2. DR InterPro; IPR006586; ADAM_Cys-rich. DR InterPro; IPR013273; ADAMTS/ADAMTS-like. DR InterPro; IPR041645; ADAMTS_CR_2. DR InterPro; IPR045371; ADAMTS_CR_3. DR InterPro; IPR010294; ADAMTS_spacer1. DR InterPro; IPR024079; MetalloPept_cat_dom_sf. DR InterPro; IPR013276; Pept_M12B_ADAM-TS5. DR InterPro; IPR001590; Peptidase_M12B. DR InterPro; IPR002870; Peptidase_M12B_N. DR InterPro; IPR000884; TSP1_rpt. DR InterPro; IPR036383; TSP1_rpt_sf. DR PANTHER; PTHR13723:SF37; A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 5; 1. DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1. DR Pfam; PF17771; ADAMTS_CR_2; 1. DR Pfam; PF19236; ADAMTS_CR_3; 1. DR Pfam; PF05986; ADAMTS_spacer1; 1. DR Pfam; PF01562; Pep_M12B_propep; 1. DR Pfam; PF01421; Reprolysin; 1. DR Pfam; PF19030; TSP1_ADAMTS; 1. DR Pfam; PF00090; TSP_1; 1. DR PRINTS; PR01860; ADAMTS5. DR PRINTS; PR01857; ADAMTSFAMILY. DR SMART; SM00608; ACR; 1. DR SMART; SM00209; TSP1; 2. DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1. DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2. DR PROSITE; PS50215; ADAM_MEPRO; 1. DR PROSITE; PS50092; TSP1; 2. PE 4: Predicted; SQ SEQUENCE 934 AA; 101775 MW; 3209D009F8AFEB92 CRC64; MLLGWASLLL GALRLPPVAA GPAAAPAQDK AGQPWAAAAA AQPRRRQGEE AREPAEPPGH PHPLAPQRRS SGLVQNVDQI YAGGGKVGYL VYAGGRRFLL DLERDGSVGA AGSAPAGRGP GAPRRHRDHC FYRGTVDGSP RSLAVLDLCG GLDGFFAVRH ARYTLKPLLR GPWAGAGAGA EAERVYGDGS PRILHVYTRE GFSFEALPPR TSCETPASPP GPRERPPAHS SPDPRWSPAP PFPAPPAASP DGGPGPQTWW RRRRRSISRA RQVELLLVAD ASMARMYGRG LQHYLLTLAS IANRLYSHAS IENHIRLAVV KVVVLGDKDK SLEVSKNAAT TLKNFCKWQH QHNQLGDDHE EHYDAAILFT REDLCGHHSC DTLGMADVGT ICSPERSCAV IEDDGLHAAF TVAHEIGHLL GLSHDDSKFC EENFGSTEDK RLMSSILTSI DASKPWSKCT SATITEFLDD GHGNCLLDLP RKQILGPEEL PGQTYDATQQ CNLTFGPEYS VCPGMDVCAR LWCAVVRQGQ MVCLTKKLPA VEGTPCGKGR ICLQGKCVDK TKKKYYSTSS HGNWGSWGSW GQCSRSCGGG VQFAYRHCNN PAPRNNGRYC TGKRAIYRSC NVTPCPPNGK SFRHEQCEAK NGYQSDAKGV KTFVEWVPKY AGVLLGDVCK LTCRAKGTGY YVVFSPKVTD GTECRPYSNS VCVRGKCVRT GCDGIIGSKL QYDKCAVCGG DNSSCTKVVG TFNKKSKGYT DVVRIPEGAT HIKVRQFKAK DQTRFTAYLA LKKKNGEYLI NGKYMISTSE TIIDINGTVM NYSGWSHRDD FLHGMGYSAT KEILIVQILA TDPTKALDVR YSFFVPKKST QKVNSVTSHA SNKVGSHTPQ LQWVTGPWLA CSRTCDTGWH TRTVQCQDAN RKLAKGCLLS QRPSAFKQCL LKKC //