ID A0A8M9QHJ3_DANRE Unreviewed; 765 AA. AC A0A8M9QHJ3; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 12-OCT-2022, entry version 2. DE SubName: Full=sulfatase 2a isoform X3 {ECO:0000313|RefSeq:XP_021335241.1}; GN Name=sulf2a {ECO:0000313|RefSeq:XP_021335241.1}; GN Synonyms=Sulf1 {ECO:0000313|RefSeq:XP_021335241.1}, sulf2 GN {ECO:0000313|RefSeq:XP_021335241.1}, zgc:55612 GN {ECO:0000313|RefSeq:XP_021335241.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_021335241.1}; RN [1] {ECO:0000313|RefSeq:XP_021335241.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_021335241.1}; RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- COFACTOR: CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; CC Evidence={ECO:0000256|ARBA:ARBA00001913}; CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000256|ARBA:ARBA00004241}. CC Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus, CC Golgi stack {ECO:0000256|ARBA:ARBA00004348}. CC -!- SIMILARITY: Belongs to the sulfatase family. CC {ECO:0000256|ARBA:ARBA00008779}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_021335241.1; XM_021479566.1. DR Proteomes; UP000000437; Chromosome 11. DR Gene3D; 3.40.720.10; -; 1. DR InterPro; IPR017850; Alkaline_phosphatase_core_sf. DR InterPro; IPR014615; Extracellular_sulfatase. DR InterPro; IPR024609; Extracellular_sulfatase_C. DR InterPro; IPR024607; Sulfatase_CS. DR InterPro; IPR000917; Sulfatase_N. DR Pfam; PF12548; DUF3740; 1. DR Pfam; PF00884; Sulfatase; 1. DR PIRSF; PIRSF036665; Sulf1; 1. DR SUPFAM; SSF53649; SSF53649; 1. DR PROSITE; PS00523; SULFATASE_1; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824}; KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..765 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5035420446" FT DOMAIN 46..377 FT /note="Sulfatase" FT /evidence="ECO:0000259|Pfam:PF00884" FT DOMAIN 534..673 FT /note="DUF3740" FT /evidence="ECO:0000259|Pfam:PF12548" FT COILED 637..664 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 765 AA; 87970 MW; C9D513980DF1908E CRC64; MAVGWRPATL LLVFILTFIC LSDGSTYLSG QRQRSRLQRD RRNVRPNMIL ILTDDQDIEL GSMQAMNKTK RIMMQGGTHF SNAFATTPMC CPSRSTILTG KYVHNHHTYT NNENCSSPSW QAHHEPHTFA VHLNNSGYRT AFFGKYLNEY NGSYVPPGWR EWVALVKNSR FYNYTLCRNG IREKHGTQYP KDYLTDVITN DSINYFRMSK RMYPHRPVMM VLSHAAPHGP EDAAPQYSSA FPNASQHITP SYNHAPNPDK HWILRYTGPM KPVHMQFTNM LQRRRLQTLL SVDDSVEKVY NMLVETGELD NTYIIYMSDH GYHIGQFGLV KGKSMPYEFD IRIPFYVRGP NVEAGAINPH IVLNTDLAPT LLDMAGIDIP QDMDGKSILK LLETERPVNS FTRFHSYKKA KLWRDSFLVE RGKPLHKLAD GKEVEQNSLP KYQRVRDLCQ RAEYQTPCEQ PGQKWQCIED GTGMPRLYKC KGMAGLFAPR ALGLMAANRG QISAAHPGSD YCDCEPAAPL KRKKALTKKK LKNKKSVPRN RWARSVPYHL DSNVYTLDLE KGYRPLNLNT SLMLGRKQAV YGQNEEYSGM GPTEDNFNSL TPPAALKVTY RCSILMNDTV KCDGGLYKSL QAWKDHKLHI EHEIETLQTK IKNLREVKGH LKEVRPKECE CNKNMYQYSS RALFKLKSAQ THSVNRMTSK DKKQWLMKEQ KRRKKLRKLL KRLRNNDTCS MPGLTCFTHD NQHWQTAPFW TSTALHATAL LSDIT //