ID A0A8M9QB78_DANRE Unreviewed; 326 AA. AC A0A8M9QB78; DT 03-AUG-2022, integrated into UniProtKB/TrEMBL. DT 03-AUG-2022, sequence version 1. DT 29-MAY-2024, entry version 11. DE SubName: Full=Troponin T2e, cardiac isoform X1 {ECO:0000313|RefSeq:XP_021330700.1}; GN Name=tnnt2e {ECO:0000313|RefSeq:XP_021330700.1, GN ECO:0000313|ZFIN:ZDB-GENE-041210-27}; GN Synonyms=si:ch211-136g2.1 {ECO:0000313|RefSeq:XP_021330700.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Proteomes:UP000000437, ECO:0000313|RefSeq:XP_021330700.1}; RN [1] {ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|RefSeq:XP_021330700.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_021330700.1}; RG RefSeq; RL Submitted (FEB-2024) to UniProtKB. CC -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin, CC the thin filament regulatory complex which confers calcium-sensitivity CC to striated muscle actomyosin ATPase activity. CC {ECO:0000256|ARBA:ARBA00003363}. CC -!- SIMILARITY: Belongs to the troponin T family. CC {ECO:0000256|ARBA:ARBA00008330}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_021330700.1; XM_021475025.1. DR AGR; ZFIN:ZDB-GENE-041210-27; -. DR ZFIN; ZDB-GENE-041210-27; tnnt2e. DR Proteomes; UP000000437; Chromosome 4. DR GO; GO:0005861; C:troponin complex; IBA:GO_Central. DR GO; GO:0005523; F:tropomyosin binding; IBA:GO_Central. DR GO; GO:0030172; F:troponin C binding; IBA:GO_Central. DR GO; GO:0031013; F:troponin I binding; IBA:GO_Central. DR GO; GO:0060048; P:cardiac muscle contraction; IBA:GO_Central. DR GO; GO:0006937; P:regulation of muscle contraction; IEA:InterPro. DR GO; GO:0045214; P:sarcomere organization; IBA:GO_Central. DR Gene3D; 1.20.5.350; -; 1. DR InterPro; IPR027707; TNNT. DR InterPro; IPR001978; Troponin. DR InterPro; IPR038077; Troponin_sf. DR PANTHER; PTHR11521; TROPONIN T; 1. DR PANTHER; PTHR11521:SF20; TROPONIN T2E, CARDIAC ISOFORM X1; 1. DR Pfam; PF00992; Troponin; 1. DR SUPFAM; SSF90250; Troponin coil-coiled subunits; 1. PE 1: Evidence at protein level; KW Muscle protein {ECO:0000256|ARBA:ARBA00023179}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A8M9QB78}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. FT REGION 1..91 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 125..214 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..56 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 125..177 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 192..214 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 326 AA; 38828 MW; BE0DC893A7F88BDD CRC64; MADTEDVVEE EVQEVEETEE EVEVPPPTEE EPAPEVEEPP EVEEEPEPEP QEAPVAEEVT DETKPKPKFM PNISAPKIPE GDKVDFDDIH RKRQEKDLSE LQSLIEAHFI QRKKDEEELI ALVNRIEKRR GERAEQQRIR AEKEKERQAR LAEEKERREQ EEQRKKHDED AKKKKALTNM THQYGGIQQK GDGRKGAKKQ TEREKKKKIL AERKKPLNID HLSEDKLKEK ASEMWQWMMQ LEAEKFDLSE KLKRQKYDCQ RSWQGQGWRQ AEVNARRIQE LQRSRRLYLL HHIQLKSELL ALLNYFLPPC IFLICPNFCL TERFYF //